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Workshop: The Cancer-Alzheimer’s Disease Nexus: Exploring Relationships, Mechanisms, and Therapeutic implications

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Target Audience

Researchers interested in learning more about the relationship between Alzheimer’s disease and cancers are invited to join this workshop.

Dates

October 18, 2022, from 9 a.m. to 3:00 p.m., ET
October 19, 2022, from 9 a.m. to 3:15 p.m., ET

Location

This workshop will be held virtually on Zoom.

Purpose and Goals

On October 18 and 19, 2022, the National Institute on Aging (NIA) will sponsor a 2-day virtual workshop on Alzheimer’s Disease and Cancer.  Recent research has suggested a complex relationship between Alzheimer’s disease and cancers.  Several potential mechanisms have been proposed and warrant further investigation. Understanding the intersection of the underlying causes and biology for these two distinct families of diseases with one another may offer novel approaches to identify new therapeutic approaches and possible opportunities to repurpose existing drug candidates.

The goal of this 2- day workshop is to set scientific priorities and determine future directions for research in this area. We look forward to exploring the state of the science, as well as the opportunities and challenges, in areas such as:

  • The link between cancer and Alzheimer’s Disease
  • Genes, Mechanisms, and Epidemiological Evidence
  • Cancer Chemotherapy and Cognitive Dysfunction
  • Meds, Mechanisms, and Drug Repurposing

Registration

Register in advance for this workshop

Agenda

Note: The draft agenda is shown below. Check back for updates.

Day 1 (Tuesday, October 18)

9:00 a.m.: Introductions and Welcome: Dallas Anderson, PhD, NIA

9:20 a.m.: Meeting overview and logistics: Damali Martin, PhD, MPH, NIA

Session 1: Why the joint interest in cancer and Alzheimer’s disease?
Session Chair: Mary Ganguli, MBBS (MD), MPH, University of Pittsburgh

  • 9:30 a.m.: Mary Ganguli, MBBS (MD), University of Pittsburgh
  • 9:40 a.m.Lindsay Kobayashi, PhD, MS, University of Michigan
  • 10:10 a.m.Michelle D. Shardell, PhD, University of Maryland
  • 10:40 a.m.Q & A, Panel of Speakers
  • 10:50 a.m.: BREAK 

Session 2: Genes, Mechanisms, and Epidemiological Evidence 
Session Chair: Marcel Salive, MD, MPH, NIA

  • 11:00 a.m.: Xianglin L. Du, MD, PhD, MS, University of Texas
  • 11:15 a.m.Monica Ospina-Romero, MD, MSA, University of Wisconsin
  • 11:30 a.m.Kelly Nudelman, PhD, Indiana University
  • 11:45 a.m.: Liming Liang, PhD, Harvard University
  • 12:00 p.m.: Q & A, Panel of speakers
  • 12:30 p.m.: LUNCH

Session 3: Cancer Chemotherapy and Cognitive Dysfunction
Chair: TBD

  • 1:30 p.m.Jeanne Mandelblatt, MD, PhD, MPH, Georgetown University
  • 1:45 p.m.: Allison Magnuson, DO, University of Rochester
  • 2:00 p.m.Andrew J Saykin, PsyD, MS, Indiana University
  • 2:15 p.m.: Q & A, Panel of Speakers
  • 2:45 p.m.: Discussion and wrap up of day 1

Day 2 (Wednesday, October 19, 2022)

9:00 a.m.: Goals for the day’s activities, Damali Martin, PhD, MPH, NIA

Session 4: Meds, Mechanisms, and Drug Repurposing
Session Chair: Paul Grothaus, PhD, NIA

  • 9:10 a.m.Mark Albers, MD, PhD, Harvard University
  • 9:25 a.m.Susan Rosenberg, PhD, Baylor University
  • 9:40 a.m.Gabriella Chiosis, PhD, Memorial Sloan Kettering Cancer Center
  • 9:55 a.m.: Q & A, Panel of Speakers
  • 10:20 a.m.: BREAK
  • 10:30 a.m.: BREAKOUT SESSION, Damali Martin and Camille Pottinger, NIA
    • Participants will contribute ideas that address current gaps in the field and set future research directions. Each group will have a facilitator and note-taker.
  • 12:30 p.m.: LUNCH (gather all responses)
  • 1:30 p.m.: Report back & Presentation of responses, Camille Pottinger, MPH, NIA
  • 2:00 p.m.: Open discussion of future directions, Dallas Anderson and Damali Martin, NIA
  • 3:00 p.m.: Closing remarks and meeting ends, NIA staff

Contact Information

Please contact Damali Martin for questions you may have about the workshop.

NIA Cancer and AD Planning Group Members:

Dallas Anderson, Division of Neuroscience
Damali Martin, Division of Neuroscience
Paul Grothaus, Division of Neuroscience
Camille Pottinger, Division of Neuroscience
Marcel Salive, Division of Geriatrics and Clinical Gerontology

Reasonable Accommodation: If you need reasonable accommodation to participate in this event, please contact the meeting organizer listed under Contact Information. Please make your request no later than 1 week before the event.

nia.nih.gov

An official website of the National Institutes of Health