Virtual Workshop: Lipids in Brain Aging and Alzheimer's Disease and Related Dementias

Dates:

• April 28, 2021: 10 a.m. - 4 p.m., ET
• April 29, 2021: 10 a.m. - 2 p.m., ET

Target audiences: Researchers interested in learning more about lipid droplets, myelin, APOE, and lipid homeostasis in the context of brain aging and AD/ADRD are invited to join this workshop

Purpose and Background

Lipids are increasingly recognized as playing an important role in brain aging and Alzheimer’s disease. The goals of this one-and-a-half day workshop are to assess the state of the science, identify gaps in knowledge, and explore areas of potential opportunity in the field. This workshop will cover the following topic areas:

• Lipid droplets in aging and Alzheimer's disease and related dementias (AD/ADRD)
• Myelin in aging and AD/ADRD
• APOE and lipid homeostasis in aging and AD/ADRD

Location

This workshop will be held virtually on Webex.

Registration Information

Please note you must register for each day of the workshop.

• Register for Day 1 of the workshop.
• Register for Day 2 of the workshop.

Agenda

Day 1 (Wednesday, April 28, 2021)

10:00 a.m. - 10:20 a.m.: Welcome and Introductions

• Dr. Eliezer Masliah, Director of Neuroscience, National Institute on Aging
• Dr. Amanda DiBattista, Division of Neuroscience, National Institute on Aging

10:20 a.m. - 12:20 p.m.: Session 1 | Lipid Droplets in Aging and AD/ADRD

• 10:20 a.m.: Lipid droplets in Alzheimer's disease: A role for APOE?, Dr. Lance Johnson, University of Kentucky, Session Chair
• 10:40 a.m.: Lipid transport from neurons to glia in health and disease, Dr. Maria S. Ioannou, University of Alberta
• 11:00 a.m.: Lipid droplet biogenesis and interactions with other organelles, Dr. Sarah Cohen, University of North Carolina at Chapel Hill
• 11:20 a.m.: Selective autophagy: When quality control meets lipid metabolism, Dr. Ana Maria Cuervo, Albert Einstein College of Medicine
• 11:40 a.m.: Lipid-droplet-accumulating microglia (LDAM) in mice and Alzheimer’s disease, Dr. Tony Wyss-Coray, Stanford University
• 12:00 p.m.: Session Discussion

12:20 p.m. - 12:40 p.m.: Break

12:40 p.m. - 2:40 p.m.: Session 2 | Myelin in Aging & AD/ADRD

• 12:40 p.m.: Myelin as ketone reservoir: Feeding a starving brain, Dr. Robbie Brinton, University of Arizona, Session Chair
• 1:00 p.m.: Factors underlying the age-related accumulation of myelin pathology and associated cognitive impairment in the normal aging rhesus monkey, Dr. Douglas Rosene, Boston University
• 1:20 p.m.: The role of myelin lipids played beyond in myelin integrity: Lessons learned from studying sulfatide deficiency in Alzheimer’s disease, Dr. Xianlin Han, University of Texas Health Science Center at San Antonio
• 1:40 p.m.: Single-cell multi-omics identifies oligodendrocyte heterogeneity in Alzheimer’s disease, Dr. Vivek Swarup, University of California, Irvine
• 2:00 p.m.: Lipoprotein lipase in neurodegenerative disease, Dr. Kimberley D. Bruce, University of Colorado Anschutz Medical Campus
• 2:20 p.m.: Session Discussion

2:40 p.m. - 3:00p.m.: Break

3:00 p.m. - 4:00p.m.: Discussion of Gaps and Opportunities (Day 1)

4:00 p.m.: Adjourn

Day 2 (Thursday, April 29, 2021)

10:00 a.m. - 11:45 a.m.: Session 3 | APOE and Lipid Homeostasis in Aging & AD/ADRD

• 10:00 a.m.: APOE in brain lipid metabolism in aging and AD: Lessons learned from animal and organoid models, Dr. Guojun Bu, Mayo Clinic, Session Chair
• 10:25 a.m.: ABCA1 activation in the CNS as a therapeutic target for Alzheimer’s disease, Dr. Mary Jo LaDu, University of Illinois at Chicago
• 10:45 a.m.: Cell-specific expression of apoE isoforms, Dr. G. William (Bill) Rebeck, Georgetown University
• 11:05 a.m.: Multiplex immunohistochemistry to investigate apolipoprotein e-related pathologies in sporadic Alzheimer’s disease, Dr. Christopher Ramsden, Intramural Research Program, National Institute on Aging
• 11:25 a.m.: Regulation of ApoE-mediated lipid signaling and the interplay between ApoE and sex on the single cell level in AD, Dr. Dongming Cai, Icahn School of Medicine at Mount Sinai

11:45 a.m. - 12:00 p.m.: Break

12:00 p.m. - 1:20 p.m.: Session 3 | APOE and Lipid Homeostasis in Aging & AD/ADRD (Continued)

• 12:00 p.m.: Brain fatty acid metabolism and neurodegeneration: a disruptive role of ApoE4, Dr. Fei Yin, University of Arizona
• 12:20 p.m.: The effects of APOE4 on carnitine/acylcarnitine mediated lipid dysfunction in Alzheimer's disease, Dr. Laila Abdullah, Roskamp Institute
• 12:40 p.m.: Translating lipoprotein and lipid studies from the bench into the clinic: gaps and opportunities, Dr. Hussein Yassine, University of Southern California
• 1:00 p.m.: Session Discussion

1:20p.m. - 2:00 p.m.: Overall Discussion of Gaps and Opportunities

2:00 p.m.: Adjourn

Contact Information

Please contact Dr. Elizabeth Newman and Dr. Amanda DiBattista for questions about this workshop.

Reasonable Accommodation: If you need reasonable accommodation to participate in this event, please contact the meeting organizer listed under Contact Information. Please make your request no later than 1 week before the event.