Neurobiology of Aging and Neurodegeneration Branch
The Neurobiology of Aging and Neurodegeneration Branch fosters research aimed at understanding how the nervous system is affected during normal and pathological aging. Research is supported on the genetic, molecular, cellular, and neural mechanisms underlying changes in the brain and its interaction with other physiological systems.
- Fundamental Neuroscience supports studies on age-related structural and functional changes in the brain, including mechanisms of selective vulnerability and plasticity of neural cells, synapses, and circuits to neurodegeneration. Research is supported on the hallmarks of aging, cellular senescence, genetics/epigenetics/chromatin, DNA damage, cell stress, proteostasis, mitochondria, metabolism, lipid neurobiology, neuroglia, neuroplasticity, neural stem cells/neurogenesis, and cell reprogramming.
- Basic Science of Alzheimer’s Disease supports examination of molecular, cellular, synaptic and circuitry mechanisms, inflammation, proteinopathy, protein polymorphisms, structural biology, and cerebrovasculature in the etiology and pathobiology of Alzheimer’s disease and other dementias of aging.
- In Integrative Neurobiology, the focus is on neural mechanisms underlying age-related changes between organ systems and the CNS, on endocrine and immune functions, and on neurodegenerative diseases associated with infectious agents.
- Sleep and Biological Rhythms encompasses age-related studies of epidemiology, etiology, pathogenesis, diagnosis, treatment, and prevention of sleep disorders of older people and of altered sleep-wake cycles/disordered biorhythmicity and their behavioral and neurodegenerative effects in aging.
Miroslaw Mackiewicz, Ph.D.
Branch Chief
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Chelsea Haakenson, Ph.D.
Health Specialist
Email Chelsea Haakenson
Joe Pottackal, Ph.D.
Health Specialist
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Caitlin Groeber Travis, Ph.D.
Health Specialist
Email Caitlin Groeber Travis
Fundamental Neuroscience
Erin Gray, Ph.D.
Program Director, Basic Research, Neurodegeneration, Cell-based systems, Selective Vulnerability
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Amanda M. DiBattista, Ph.D.
Program Director, Neuroplasticity, Glia, Lipid Neurobiology, Cellular Senescence
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Paul Barrett, Ph.D.
Program Director, Cell Metabolism, Homeostasis, Stress Response
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Elizabeth Newman, Ph.D.
Program Director, Neurodevelopment, Neuroprotection
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Basic Science of Alzheimer’s Disease and Related Diseases
Austin Yang, Ph.D.
Program Director, Etiology of Alzheimer’s Disease
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Elizabeth Newman, Ph.D.
Program Director, Cerebrovascular Biology in Aging Brain and AD
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Lisa Opanashuk, Ph.D.
Program Director, Pathobiology of Alzheimer’s Disease
Email Lisa Opanashuk
Tong Li, Ph.D.
Program Director, Etiology/Pathobiology of Alzheimer’s Disease
Email Tong Li
Integrative Neurobiology
Miroslaw Mackiewicz, Ph.D.
Program Director, Integrative Neurobiology
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Maja Maric
Program Director, Neuroimmunology, Neurovirology and Infectious Agents
Email Maja Maric
Sleep and Biological Rhythms
Miroslaw Mackiewicz, Ph.D.
Program Director, Sleep Disorders and Biological Rhythms
Email Miroslaw Mackiewicz
Number | Title | Release Date | Expiration Date | NIA Contact |
---|---|---|---|---|
RFA-AG-24-046 | Chimeric Antigen Receptor (CAR) Approaches to AD/ADRD (R61/R33 Clinical Trial Not Allowed) | 8/23/2023 | 2/8/2024 | Maja Maric |
PAR-23-046 | Engineering Next-Generation Human Nervous System Microphysiological Systems (R01 Clinical Trials Not Allowed) | 11/10/2022 | 1/8/2026 | Amanda DiBattista |
PAR-23-047 | Engineering Next-Generation Human Nervous System Microphysiological Systems (R21 Clinical Trials Not Allowed) | 11/10/2022 | 1/8/2026 | Amanda DiBattista |
PA-20-149 | HIV Infection of the Central Nervous System (R01 Clinical Trial Not Allowed) | 5/13/2020 | 5/8/2023 | Mack Mackiewicz |
RFA-AG-24-018 | Team Science Approaches Integrating Experimental and Computational Brain Aging Models | 2/1/2022 | 9/22/2023 | Amanda DiBattista |
Number | Title | Release Date | Expiration Date | NIA Contact |
---|---|---|---|---|
NOT-AG-21-039 | Understanding Alzheimer’s Disease in the Context of the Aging Brain | 12/30/2021 | 11/13/2024 | Erin Gray |
NOT-AG-21-040 | Selective Cell and Network Vulnerability in Aging and Alzheimer’s Disease | 1/05/2022 | 11/13/2024 | Erin Gray |
NOT-AG-21-041 | Capturing Complexity in the Molecular and Cellular Mechanisms Involved in the Etiology of Alzheimer’s Disease | 1/06/2022 | 11/13/2024 | Austin Yang |
NOT-AG-21-042 | Deciphering the Glycosylation Code of Alzheimer’s Disease | 1/06/2022 | 11/13/2024 | Austin Yang |
NOT-AG-21-043 | Infectious Etiology of Alzheimer’s Disease | 1/10/2022 | 11/13/2024 | Mack Mackiewicz |
NOT-AG-21-051 | Sleep Disorders and Circadian Clock Disruption in Alzheimer's Disease and other Dementias of Aging | 1/10/2022 | 11/13/2024 | Mack Mackiewicz |
NOT-AG-21-052 | Human Cell Biology of Alzheimer’s Disease Genetic Variants | 1/07/2022 | 11/13/2024 | Amanda DiBattista |