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DN Initiatives, Centers, and Resources

Moving neuroscience research forward

NIA's Division of Neuroscience supports major initiatives, centers, and resources to advance Alzheimer's and related dementias and brain health research on many fronts.

Initiatives

Accelerating Medicines Partnership - Alzheimer's Disease (AMP-AD)

The AMP-AD program is a precompetitive partnership among government, industry, and nonprofit organizations that focuses on discovering novel, clinically relevant therapeutic targets and on developing biomarkers to help validate existing therapeutic targets.

Alzheimer’s Biomarker Consortium – Down Syndrome (ABC-DS)

The ABC-DS study is a joint study conducted by two groups of research collaborators—Neurodegeneration in Aging Down Syndrome (NiAD) and Alzheimer's Disease in Down Syndrome (ADDS)—and is supported by NIA and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD).

Alzheimer's Clinical Trials Consortium (ACTC)

The ACTC is expected to accelerate and expand studies for therapies in Alzheimer’s disease and related dementias. The infrastructure of 35 sites across the United States will address the timeframe, complexity and expense of the recruitment process and site activation for Alzheimer’s trials to find new and effective ways to treat or prevent these devastating disorders.

Alzheimer's Disease Genetics Portfolio

The Genetics of Alzheimer’s Disease Portfolio supports research to discover long term treatments for the disease by the identification of risk factor and protective genes and the underlying molecular pathways.

Alzheimer's Disease Neuroimaging Initiative

Launched in 2004, ADNI is an ongoing, longitudinal, multicenter study designed to develop clinical, imaging, genetic, and biochemical biomarkers for the early detection and tracking of Alzheimer’s disease.

Alzheimer's Pre-Clinical Efficacy Database (Alz-PED)

AlzPED is a publicly available, searchable, data resource that aims to increase the transparency, reproducibility and translatability of preclinical efficacy studies of candidate therapeutics for Alzheimer’s disease.

AD Translational Initiatives

Cognitive and Emotional Health Project (CEHP): The Healthy Brain

CEHP is a trans-NIH initiative aiming to understand the positive and negative changes in cognition and emotion in adulthood, and what can be done to preserve and enhance positive outcomes.

Dominantly Inherited Alzheimer’s Network (DIAN)

DIAN is an international research effort to find solutions to treat or prevent this disease and, potentially, all forms of Alzheimer’s.

Model Organism Development and Evaluation for Late-Onset AD (MODEL-AD)

The MODEL-AD initiative works to develop, validate and disseminate new, precise animal models of Alzheimer’s disease.

Molecular Mechanisms of the Vascular Etiology of Alzheimer's Disease Consortium (M2OVE-AD)

M2OVE-AD is an NIH-led team-science venture to build a nuanced model of Alzheimer's disease that more accurately reflects its many causes and pathways.

Centers and Resources

Alzheimer's Disease Research Centers (ADCs)

NIA-funded Alzheimer's Disease Centers (ADCs) work to translate research advances into improved diagnosis and care, as well as find ways to treat and possibly prevent Alzheimer's disease and related dementias.

National Alzheimer's Coordinating Center (NACC)

Funded by NIA, NACC has developed and maintains a large relational database of standardized clinical and neuropathological research data. NACC provides a valuable resource for both exploratory and explanatory Alzheimer's disease research. NACC data are freely available to all researchers.

International Alzheimer's Disease Research Portfolio (IADRP)

Launched in 2010 as a joint collaboration between the NIA and the Alzheimer's Association, IADRP enables users to assess the portfolios of major organizations for areas of overlap as well as areas of opportunities in which to collaborate and coordinate in a collective effort to advance AD research.

National Cell Repository for Alzheimer's Disease (NCRAD)

The goal of the National Cell Repository for Alzheimer’s Disease (NCRAD) is to help researchers find genes that increase the risk for Alzheimer’s disease (AD) and dementia.

NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS)

NIAGADS is the National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site. NIAGADS is a national genetics repository created by NIA to facilitate access by qualified investigators to genotypic data for the study of genetics of late-onset Alzheimer's disease.

NIH Resources

NIH Toolbox for Assessment of Neurological and Behavioral Function

The NIH Toolbox® is a comprehensive set of neuro-behavioral measurements that quickly assess cognitive, emotional, sensory, and motor functions.

NIH Blueprint/Human Connectome Project

Lifespan Connectome Project

NIH BRAIN Initiative

NIH Blueprint/Neurotherapeutics Program

HIV NeuroAids Therapeutics Program

ClinicalTrials.gov