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AMP-AD Biomarkers Project

Accelerating Medicines Partnership (AMD) Alzheimer's Disease

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Project Description

The Accelerating Medicines Partnership-Alzheimer's Disease (AMP-AD) Biomarkers Project is a consortium of two NIA-supported Phase II/III secondary prevention trials (listed below) testing several anti-amyloid therapies. Through the AMP-AD partnership, imaging and fluid biomarker panels already included in these trials will be supplemented with tau PET imaging and novel fluid biomarkers.

The goal is to explore the utility of tau imaging and novel fluid biomarkers for tracking responsiveness to treatment and/or disease progression. Baseline data from the trials will be made broadly available through the Alzheimer Association’s GAAIN collaborative platform.

Biomarkers Consortium Grants

Alzheimer’s Disease Cooperative Study (ADCS) Anti-Amyloid Treatment in Asymptomatic Alzheimer’s Disease Trial (A4 Trial) (U19AG010483)

Principal Investigators:
Reisa Sperling, Harvard Medical School
Paul Aisen, University of California, San Diego

Dominantly Inherited Alzheimer Network (DIAN) Trial (U01AG042791)

Principal Investigator:
Randall Bateman, Washington University