Alzheimer's Clinical Trials Consortium (ACTC)
The Alzheimer's Clinical Trials Consortium (ACTC) is a clinical trials infrastructure launched in December, 2017 and designed to accelerate and expand studies for therapies in Alzheimer's disease and related dementias. ACTC's mission is to provide an optimal infrastructure, utilizing centralized resources and shared expertise, to accelerate the development of effective interventions for Alzheimer’s disease and related disorders.
The ACTC is jointly led by:
- Paul Stephen Aisen, M.D., director of the ATRI at the Keck School of Medicine of USC, San Diego
- Reisa A. Sperling, M.D., director of the Center for Alzheimer Research and Treatment at the Brigham and Women's Hospital, professor of Neurology, Harvard Medical School, Boston
- Ronald C. Petersen, M.D., Ph.D., director of the Mayo Clinic Alzheimer's Disease Research Center, professor of Neurology at Mayo Clinic College of Medicine and Science, Rochester, Minnesota
The ACTC is a cooperative agreement between the NIA and the grantees institutions. The NIA Project Scientist for the ACTC is Laurie Ryan.
Working with the ACTC is a cooperative venture between the applicant, NIA, and the ACTC network. Prior to applying to the ACTC R01 Funding Opportunity Announcement (PAR-18-513), prospective applicants should follow this pre-application process:
- Step 1: Contact NIA. We strongly encourage that all applicants contact NIA program staff (listed below) in the early planning phases of any study to discuss the feasibility of conducting the proposed trial through the ACTC infrastructure.
- Step 2: Contact ACTC.
- Applicants must submit an ACTC Clinical Study Concept Proposal. This proposal includes the specific aims for the study, relevant preliminary data, and study design.
- The proposal will be reviewed first by the Protocol Evaluation Committee, and if allowed to move forward, will be voted on by the ACTC Steering Committee. The NIA project scientist is part of these committees.
- Interested applicants should contact the ACTC program administrator, Sarah Walter.
- Step 3: Apply to the FOA. (Note: Approval by the ACTC Steering Committee does not guarantee NIA funding.) If your proposal is approved by the ACTC steering committee, you may then formally apply to the ACTC R01 Funding Opportunity Announcement (PAR-18-513) with help from the ACTC Coordinating Center. Your application will then undergo NIH peer review and will receive an impact score. Applications will be funded based on score and NIA funding priorities.
- Applications that exceed $500,000 in direct costs in any one year require prior approval before submission (NOT-OD-02-004). The applicant will need to contact NIA program staff, and any requests for submission must be received at least six weeks prior to the submission deadline.
Proposed Development Steps and Timelines
|FOA Submission Date||Step 1: Proposal Submission||Step 2: PFC Review||Step 3: PEC Review||Step 4: SC Discussion and Vote||Step 5: Project Selection & Grant Development||Step 6: Proposal Submission|
Feb 5, 2019
|Aug 5, 2018||Aug 13-15, 2018||Sept 10-14, 2018||Oct 21, 2018||Nov 5, 2018||Jan 22, 2019|
June 5, 2019
|Dec 5, 2018||Dec 12-14, 2018||Jan 7-11, 2019||Feb 8, 2019||Feb 18, 2019||May 22, 2019|
Oct 5, 2019
|Apr 5, 2019||Apr 11-12, 2019||Apr 22-26, 2019||May 5, 2019||May 13, 2019||Sept 21, 2019|
Feb 5, 2020
|Aug 5, 2019||Aug 12-14, 2019||Sept 9-13, 2019||Oct 13, 2019||Oct 21, 2019||Jan 22, 2020|
June 5, 2020
|Dec 5, 2019||Dec 12-13, 2019||Jan 6-10, 2020||
Jan - Feb, 2020
|Mar, 2020||May 22, 2020|
Oct 5, 2020
|Apr 6, 2020||Apr 13-15, 2020||May 11-15, 2020||Apr 25, 2020||May 4, 2020||Sept 21, 2020|
Feb 5, 2021
Aug 3, 2020
|Aug 10-12, 2020||May 7-11, 2020||Oct 4, 2020||Oct 12, 2020||Jan 22, 2021|
June 5, 2021
|Dec 7, 2020||Dec 14-16, 2020||Jan 11-15, 2021||Jan-Feb, 2021||Mar, 2021||Jun 21, 2021|
ACTC Steering Committee Sites
The ACTC network consists of 35 sites in 24 states:
|ACTC Network Site||Principal Investigator||City||State|
|Banner Alzheimer's Institute||William Burke, MD||Phoenix||AZ|
|Banner Sun Health Research Institute (SHRI)||Edward Zamrini, MD||Sun City||AZ|
|Brigham and Women's Hospital||Gad Marshall, MD||Boston||MA|
|Butler Hospital Memory and Aging Center||Stephen Salloway, MD||Providence||RI|
|Case Western Reserve University||Alan Lerner, MD||Beachwood||OH|
|Cleveland Clinic Lou Ruvo Center for Brain Health||Marwan Sabbagh, MD||Las Vegas||NV|
|Columbia University Medical Center||Karen Bell, MD||New York||NY|
|Emory University School of Medicine||Ihab Hajjar, MD, MS||Atlanta||GA|
|Georgetown University||Raymond Scott Turner, MD, PhD||Washington||DC|
|Howard University||Thomas Obisesan, MD, MPH||Washington||DC|
|Indiana University||Martin Farlow, MD||Indianapolis||IN|
|Johns Hopkins University||Paul Rosenberg, MD||Baltimore||MD|
|Mayo Clinic, Jacksonville||Neil Graff-Radford, MD||Jacksonville||FL|
|Mayo Clinic, Rochester||Jonathan Graff-Radford, MD||Rochester||MN|
|Mount Sinai School of Medicine||Mary Sano, PhD||New York||NY|
|Oregon Health & Science University||Lisa Silbert, MD, MCR||Portland||OR|
|Roper St. Francis-Clinical Biotechnology Research Institute||Jacobo Mintzer, MD||Charleston||SC|
|Rush University Medical Center||Neelum Aggarwal, MD||Chicago||IL|
|Stanford University||Victor Henderson, MD, MS||Palo Alto||CA|
|UC Davis||John Olichney, MD||Davis||CA|
|UC Irvine||Joshua Grill, PhD||Irvine||CA|
|UC San Francisco||Adam Boxer, MD, PhD||San Francisco||CA|
|University of Alabama at Birmingham||David Geldmacher, MD||Birmingham||AL|
|University of Kansas Medical Center||Jeffrey Burns, MD, MS||Kansas City||KS|
|University of Kentucky||Gregory Jicha, MD, PhD||Lexington||KY|
|University of Michigan||Judith Heidebrink, MD, MS||Ann Arbor||MI|
|University of Pennsylvania||Jason Karlawish, MD||Philadelphia||PA|
|University of Pittsburgh||Oscar Lopez, MD||Pittsburgh||PA|
|University of Rochester||Anton Porsteinsson, MD||Rochester||NY|
|University of South Florida / Byrd Institute||Amanda Smith, MD||Tampa||FL|
|University of Southern California||Lon Schneider, MD||Los Angeles||CA|
|University of Washington (SIBCR)||Elaine Peskind, MD||Seattle||WA|
|Wake Forest School of Medicine||Suzanne Craft, MD||Winston-Salem||NC|
|Washington University||Joy Snider, MD, PhD||Saint Louis||MO|
|Yale University||Christopher van Dyck, MD||New Haven||CT|
Frequently Asked Questions
Is ACTC the only means by which NIA funds Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) clinical trials?
No, the ACTC is limited in its capacity to 5-7 trials during the five-year award period. Furthermore, not every trial is appropriate for this consortium. NIA has a long-standing history of funding pharmacological and non-pharmacological AD/ADRD clinical trials through several other means, and will continue to so:
- Pilot Clinical Trials for the Spectrum of Alzheimer's Disease and Age-related Cognitive Decline (R01 Clinical Trial Optional) (PAR-18-175)
- Phase III Clinical Trials for the Spectrum of Alzheimer's Disease and Age-related Cognitive Decline (R01 Clinical Trial Required) (PAR-18-028)
Do I need to plan my study to use all 35 of the ACTC sites?
No, not every study will use all the sites. The number and choice of sites should be tailored to the specific project being proposed.
Can I propose sites for my study in addition to the ACTC sites?
Yes, you may propose additional sites if there is scientific or practical rationale for doing so.
NIA Project Scientist (Pharmacological Interventions):
Laurie Ryan, Ph.D.
National Institute on Aging (NIA)
Email Laurie Ryan
NIA Program Officer (Non-Pharmacological Interventions):
Kristina McLinden, Ph.D.
National Institute on Aging (NIA)
Email Kristina McLinden