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Alzheimer's Clinical Trials Consortium (ACTC)

Alzheimer's Clinical Trials Consortium (ACTC) logo

The Alzheimer's Clinical Trials Consortium (ACTC) is a clinical trials infrastructure launched in December, 2017 and designed to accelerate and expand studies for therapies in Alzheimer's disease and related dementias. ACTC's mission is to provide an optimal infrastructure, utilizing centralized resources and shared expertise, to accelerate the development of effective interventions for Alzheimer’s disease and related disorders.

The ACTC is jointly led by:

  • Paul Stephen Aisen, M.D., director of the ATRI at the Keck School of Medicine of USC, San Diego
  • Reisa A. Sperling, M.D., director of the Center for Alzheimer Research and Treatment at the Brigham and Women's Hospital, professor of Neurology, Harvard Medical School, Boston
  • Ronald C. Petersen, M.D., Ph.D., director of the Mayo Clinic Alzheimer's Disease Research Center, professor of Neurology at Mayo Clinic College of Medicine and Science, Rochester, Minnesota

The ACTC is a cooperative agreement between the NIA and the grantees institutions. The NIA Project Scientist for the ACTC is Laurie Ryan.

Pre-Application Process

Working with the ACTC is a cooperative venture between the applicant, NIA, and the ACTC network. Prior to applying to the ACTC R01 Funding Opportunity Announcement (PAR-18-513), prospective applicants should follow this pre-application process:

  • Step 1: Contact NIA. We strongly encourage that all applicants contact NIA program staff (listed below) in the early planning phases of any study to discuss the feasibility of conducting the proposed trial through the ACTC infrastructure.
  • Step 2: Contact ACTC.
    • Applicants must submit an ACTC Clinical Study Concept Proposal. This proposal includes the specific aims for the study, relevant preliminary data, and study design.
    • The proposal will be reviewed first by the Protocol Evaluation Committee, and if allowed to move forward, will be voted on by the ACTC Steering Committee. The NIA project scientist is part of these committees.
    • Interested applicants should contact the ACTC program administrator, Sarah Walter.
  • Step 3: Apply to the FOA. (Note: Approval by the ACTC Steering Committee does not guarantee NIA funding.) If your proposal is approved by the ACTC steering committee, you may then formally apply to the ACTC R01 Funding Opportunity Announcement (PAR-18-513) with help from the ACTC Coordinating Center. Your application will then undergo NIH peer review and will receive an impact score. Applications will be funded based on score and NIA funding priorities.
    • Applications that exceed $500,000 in direct costs in any one year require prior approval before submission (NOT-OD-02-004). The applicant will need to contact NIA program staff, and any requests for submission must be received at least six weeks prior to the submission deadline.

Proposed Development Steps and Timelines

FOA Submission Date Step 1: Proposal Submission Step 2: PFC Review Step 3: PEC Review Step 4: SC Discussion and Vote Step 5: Project Selection & Grant Development Step 6: Proposal Submission
Feb 5, 2019
Aug 5, 2018 Aug 13-15, 2018 Sept 10-14, 2018 Oct 21, 2018 Nov 5, 2018 Jan 22, 2019
June 5, 2019
Dec 5, 2018 Dec 12-14, 2018 Jan 7-11, 2019 Feb 8, 2019 Feb 18, 2019 May 22, 2019
Oct 5, 2019
Apr 5, 2019 Apr 11-12, 2019 Apr 22-26, 2019 May 5, 2019 May 13, 2019 Sept 21, 2019
Feb 5, 2020
Aug 5, 2019 Aug 12-14, 2019 Sept 9-13, 2019 Oct 13, 2019 Oct 21, 2019 Jan 22, 2020
June 5, 2020
Dec 5, 2019 Dec 12-13, 2019 Jan 6-10, 2020

Jan - Feb, 2020

Mar, 2020 May 22, 2020
Oct 5, 2020
Apr 6, 2020 Apr 13-15, 2020 May 11-15, 2020 Apr 25, 2020 May 4, 2020 Sept 21, 2020
Feb 5, 2021

Aug 3, 2020

Aug 10-12, 2020 May 7-11, 2020 Oct 4, 2020 Oct 12, 2020 Jan 22, 2021
June 5, 2021
Dec 7, 2020 Dec 14-16, 2020 Jan 11-15, 2021 Jan-Feb, 2021 Mar, 2021 Jun 21, 2021

ACTC Steering Committee Sites

The ACTC network consists of 35 sites in 24 states:

ACTC Network Site Principal Investigator City State
Banner Alzheimer's Institute William Burke, MD Phoenix AZ
Banner Sun Health Research Institute (SHRI) Edward Zamrini, MD Sun City AZ
Brigham and Women's Hospital Gad Marshall, MD Boston MA
Butler Hospital Memory and Aging Center Stephen Salloway, MD Providence RI
Case Western Reserve University Alan Lerner, MD Beachwood OH
Cleveland Clinic Lou Ruvo Center for Brain Health Marwan Sabbagh, MD Las Vegas NV
Columbia University Medical Center Karen Bell, MD New York NY
Emory University School of Medicine Ihab Hajjar, MD, MS Atlanta GA
Georgetown University Raymond Scott Turner, MD, PhD Washington DC
Howard University Thomas Obisesan, MD, MPH Washington DC
Indiana University Martin Farlow, MD Indianapolis IN
Johns Hopkins University Paul Rosenberg, MD Baltimore MD
Mayo Clinic, Jacksonville Neil Graff-Radford, MD Jacksonville FL
Mayo Clinic, Rochester Jonathan Graff-Radford, MD Rochester MN
Mount Sinai School of Medicine Mary Sano, PhD New York NY
Oregon Health & Science University Lisa Silbert, MD, MCR Portland OR
Roper St. Francis-Clinical Biotechnology Research Institute Jacobo Mintzer, MD Charleston SC
Rush University Medical Center Neelum Aggarwal, MD Chicago IL
Stanford University Victor Henderson, MD, MS Palo Alto CA
UC Davis John Olichney, MD Davis CA
UC Irvine Joshua Grill, PhD Irvine CA
UC San Francisco Adam Boxer, MD, PhD San Francisco CA
University of Alabama at Birmingham David Geldmacher, MD Birmingham AL
University of Kansas Medical Center Jeffrey Burns, MD, MS Kansas City KS
University of Kentucky Gregory Jicha, MD, PhD Lexington KY
University of Michigan Judith Heidebrink, MD, MS Ann Arbor MI
University of Pennsylvania Jason Karlawish, MD Philadelphia PA
University of Pittsburgh Oscar Lopez, MD Pittsburgh PA
University of Rochester Anton Porsteinsson, MD Rochester NY
University of South Florida / Byrd Institute Amanda Smith, MD Tampa FL
University of Southern California Lon Schneider, MD Los Angeles CA
University of Washington (SIBCR) Elaine Peskind, MD Seattle WA
Wake Forest School of Medicine Suzanne Craft, MD Winston-Salem NC
Washington University Joy Snider, MD, PhD Saint Louis MO
Yale University Christopher van Dyck, MD New Haven CT

Frequently Asked Questions

Is ACTC the only means by which NIA funds Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) clinical trials?

No, the ACTC is limited in its capacity to 5-7 trials during the five-year award period. Furthermore, not every trial is appropriate for this consortium. NIA has a long-standing history of funding pharmacological and non-pharmacological AD/ADRD clinical trials through several other means, and will continue to so:

  • Pilot Clinical Trials for the Spectrum of Alzheimer's Disease and Age-related Cognitive Decline (R01 Clinical Trial Optional) (PAR-18-175)
  • Phase III Clinical Trials for the Spectrum of Alzheimer's Disease and Age-related Cognitive Decline (R01 Clinical Trial Required) (PAR-18-028)

Do I need to plan my study to use all 35 of the ACTC sites?

No, not every study will use all the sites. The number and choice of sites should be tailored to the specific project being proposed.

Can I propose sites for my study in addition to the ACTC sites?

Yes, you may propose additional sites if there is scientific or practical rationale for doing so.

Program Contacts

NIA Project Scientist (Pharmacological Interventions):
Laurie Ryan, Ph.D.
National Institute on Aging (NIA)
Telephone: 301-496-9350
Email Laurie Ryan

NIA Program Officer (Non-Pharmacological Interventions):
Kristina McLinden, Ph.D.
National Institute on Aging (NIA)
Telephone: 301-496-9350
Email Kristina McLinden