Skip to main content

Pre-Application Information for RFA-AG-18-018: "Development of Valid Reliable Markers of Aging-Related Biologic Mechanisms for Human Studies (U01)"

RFA-AG-18-018, "Development of Valid Reliable Markers of Aging-Related Biologic Mechanisms for Human Studies" was published on September 21, 2017. This is a collaborative initiative between the NIA Division of Geriatrics and Clinical Gerontology (DGCG) and the Division of Aging Biology (DAB).

This Funding Opportunity Announcement (FOA) encourages applications to develop valid markers to assess the activity of fundamental aging mechanisms in humans that may influence the risk and progression of multiple aging conditions. Projects are encouraged that focus on selected mechanism(s) that may regulate aging changes, assess multiple possible markers for these mechanisms, test methods to improve their measurement properties, characterize their variability among individuals of differing ages and within the same age cohort, and assess their relationships in humans to in vivo functions influenced by the mechanism(s) under study. It is strongly encouraged that each project includes an interdisciplinary research team with expertise, as needed, in the biology of their selected mechanism(s), biomedical aging research, clinical pathology including laboratory assays, imaging methods, human cohort studies, tissue banking, biorepository resources, and statistics. Though the principal focus of the initiative is on development of markers in humans, studies in laboratory animals may also be conducted when necessary for the development of human markers, and potential development of parallel laboratory animal markers of a given mechanism.

Full details of this FOA are available at:


Please note that important deadlines for this RFA are:

  • Letters of intent- December 30, 2017
  • Application receipt date- January 30, 2018.

Pre-Application Webinar

A pre-application webinar was held on Friday, October 27, 2017 from 3:15 pm – 5:00 pm (Eastern). An archived version of the webinar presentation is available on YouTube.

Contact Information

We strongly encourage applicants to contact the NIA to discuss their proposed projects.

Further questions may be directed to:

Chhanda Dutta, PhD
Division of Geriatrics and Clinical Gerontology, NIA

Please check this page periodically, as FAQ's may be added in the future.