Research and Funding

Division of Extramural Activities

R21: Exploratory/Developmental Grants

Exploratory/Developmental Grants (R21) are supported by NIA in its four extramural programs. Topics currently being solicited through this mechanism are available from the individual program Web sites as listed below. Interested applicants should follow instructions in the NIH R21 PA:

  • DAB accepts R21 applications in areas providing new avenues of research on the molecular, cellular, physiological, and genetic mechanisms of aging within the mission of the program.
  • DBSR accepts R21 applications in its areas of emphasis, including:
    • Health Disparities
    • Aging Minds
    • Increasing Health Expectancy
    • Health, Work, and Retirement
    • Interventions and Behavior Change
    • Genetics, Behavior, and the Social Environment
    • The Burden of Illness and the Efficiency of Health System
  • DN accepts R21 applications in all areas of NNA's mission focusing on research to understand the aging process in the structure and functioning of the nervous system and the brain-behavior relationship. An important component of this program is the support of basic, clinical, and epidemiological studies of Alzheimer's disease and related dementias of aging. Of special interest are innovative and high-impact studies focused on identifying, preventing, and treating neurodegenerative disorders and cognitive declines associated with aging.

  • DGCG accepts R21 applications involving research on health and disease in the aged and research on aging during the human lifespan and its relationships to health outcomes, consistent with the mission of the program. Specifically, i) Longevity associated variants (LAV) such as ApoE2 to improve understanding of physiologic and cellular differences attributable to the protective variant(s) and how they mediate differential effects on longevity and risk for age-related conditions. ii) Identification of potential therapeutic targets based on LAV(s)for interventions that prevent or ameliorate aging-related diseases and enhance human life and health span consistent with the mission of our program.