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Workshop: The Long-Term Effects of Pregnancy on Aging

Dates

November 1, 2023 | 8:00 a.m. to 6:30 p.m. ET

Location

This virtual workshop will be held over Zoom (webinar), and speakers and staff will be present in Bethesda, MD. No sign language interpreters will be provided, but transcription and closed captioning services (CART, or Communication Access Real-Time Translation provided by Access Interpreting) will be available. Attendees can join this meeting via Zoom.

Purpose and Background

NIA’s Division of Aging Biology will host the workshop, Long-Term Effects of Pregnancy on Aging, in consultation with NIH’s Office of Research on Women’s Health and the Eunice Kennedy Shriver National Institute on Child Health and Development. The workshop will be held on Nov. 1, 2023 from 8:00 a.m. to 6:30 p.m., ET. This workshop will examine the state of the science on established and possible relationships between pregnancy and aging. It will also explore the major research gaps and opportunities on the enduring effects of pregnancy on the health of parous women.

Speakers will present their research on the costs of reproduction on aging, how pregnancy affects the hallmarks and metrics of aging, and the effect of pregnancy complications. Participants will add commentary to these presentations to encapsulate the scope of research questions regarding pregnancy and its relationship to aging. At the end of this workshop, an overarching discussion will be held on existing knowledge gaps and areas of greatest need within this field of research.

Registration

Register for this workshop

Agenda

Note: This agenda is in Eastern Daylight Time.

Wednesday, November 1

8:00 - 8:30 a.m. Opening Remarks

8:30 - 10:20 a.m. What are the biological costs of reproduction (CoR) on aging?, Chair: Yousin Suh, Columbia University

  • Costs of reproduction from a uterine perspective, Kara McKinley, Harvard University
  • Cross-sectional and longitudinal changes in gravidity are associated with accelerated epigenetic age in young and middle-aged women in the Philippines, Calen Ryan, Columbia University
  • The Long-Term Costs of Reproduction in High Fertility Population, Grazyna Jasienska, Jagiellonian University
  • Previous Parity alters the Trajectory of Brain Aging, Liisa Galea, University of British Columbia
  • Session discussion

10:20 - 10:30 a.m. Break

10:30 - 12:40 p.m. Effects of pregnancy on selected hallmarks and metrics of aging, Chair: Elena Gorodetsky, ORWH, NIH

  • Quantifying Biological Age in the Context of Reproduction, Vadim Gladyshev, Harvard University
  • Molecular, Cellular, and Genetic Signatures of Reproduction in Women, Yousin Suh, Columbia University
  • Forever chemicals and endometriosis, Anna Pollack, George Mason University
  • Lactation, oxytocin and maternal aging, Egle Bytautiene Prewit, University of Texas Health San Antonio
  • Systemic Influences on Pregnancy and Aging: A Health Equity Lens, Lens Jaime Slaughter-Acey, University of North Carolina at Chapel Hill
  • Session discussion

12:40 - 1:40 p.m. Lunch Break (on your own)

1:40 - 4:10 p.m. Effects of gestational period length and adverse pregnancy outcomes on future maternal health, Chair: Janet Rich-Edwards, Brigham and Women’s Hospital, Harvard Medical School

  • The chicken or the egg? Cautions on cause and correlation, Janet Rich-Edwards, Brigham and Women’s Hospital, Harvard Medical School
  • Preeclampsia: a mechanistic overview of pathways through which this APO may accelerate cardiovascular aging, Natalie Bello, Smidt Heart Institute, Cedars-Sinai Medical Center
  • Adverse Pregnancy Outcomes and Vascular Cognitive Impairment: Clinical Perspective
  • Eliza Miller, Columbia University
  • Modelling Long-term Postpartum Neurological Disorders after Pregnancy Complications in Preclinical Studies, J. Paula Warrington, University of Mississippi Medical Center
  • Gestational Diabetes and Future Cardiovascular and Metabolic Health, Anna Stanhewicz, University of Iowa
  • The relation of placental pathology to later life cardiovascular disease in women, W. Tony Parks, University of Toronto
  • Session discussion

4:10 - 4:20 p.m. Break

4:20 - 6:30 p.m. Future directions and knowledge gaps for aging research in parous women, Chair: Fei Wang, NIA, NIH

  • Session summaries, 20 minutes for each session; the chair of each session will take 5 minutes to present the collective priorities from their session, and there will be 15 minutes of general discussion to reprioritize these collective priorities.

6:30 p.m. Closing remarks

Contact Information

Please contact Katherine Kim for questions you may have about the workshop.

Reasonable Accommodation: If you need reasonable accommodation to participate in this event, please contact Katherine Kim. Please make your request no later than 1 week before the event.

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