Workshop: Heterogeneity and Successful Aging

Audience

Researchers at all career stages from academia, government, and industry with a shared interest in the biology of aging and heterogeneity in aging phenotypes across study cohorts.

Dates

May 8, 2023 | 10:00 a.m. - 5:00 p.m. ET
May 9, 2023 | 10:00 a.m. - 4:00 p.m. ET

Location

This virtual workshop took place via Zoom.

Purpose and Background

The purpose of this virtual workshop was to discuss current and new approaches to investigate successful aging, including experimental and statistical methods/models. The main objectives of this workshop were to: 1) Gather background information on heterogeneity in aging study cohorts, 2) Explore strategies to investigate phenotypes that are associated/predictive of successful/unsuccessful aging and prolonged healthy lifespan; 3) Identify the challenges and opportunities posed by heterogeneity in aging study cohorts; 4) Discuss how heterogeneity in study cohorts can be harnessed to understand the factors that determine successful aging, prolonged health, organ/tissue integrity and functionality (lifespan vs healthspan).

Agenda

Note: This agenda is in Eastern Daylight Time.

Day 1 (Monday, May 8, 2023)

10:00 a.m. - 11:00 a.m.: Welcome and Keynote Address

• Welcome, Overview, and Goals of the Workshop
• Keynote Presentation, George Kuchel, M.D., University of Connecticut, The Path from Heterogeneity of Aging and Successful Aging to Precision Gerontology and Geroscience

11:00 a.m. - 2:15 p.m.: Session 1 | Heterogeneity in Study Cohorts/Populations

• Michal Engelman, Ph.D., M.H.S., University of Wisconsin - Madison, Heterogeneity in Human Population Studies: Towards Understanding the Biological Embodiment of Social Stratification
• Vivek Kumar, Ph.D., The Jackson Laboratories, Automated behavior quantification for preclinical aging studies in the laboratory
• Claire Bedbrook, Ph.D., Stanford University, Whole-lifespan behavioral tracking to model aging and predict remaining life
• Break (12:35 p.m. - 1:15 p.m.)
• Alice Kane, Ph.D., Institute for Systems Biology, Measuring heterogeneity in health in mice: frailty and epigenetic clocks
• Gary Churchill, Ph.D., The Jackson Laboratories, Aging studies with genetically diverse mice

2:15 p.m. - 4:40 p.m.: Session 2 | Heterogeneous Response to Perturbations in Animal Models

• Isabel Beerman, Ph.D., NIA, The effect of periodic restricted feeding (PRF) on Rhesus Macaques and Mus Musculus
• Andrea Hevener, Ph.D., UCLA, Leveraging heterogeneity to drive innovation in metabolic health research across lifespan
• Break (3:20 p.m. - 3:40 p.m.)
• Rozalyn Anderson, Ph.D., University of Wisconsin - Madison, Aging in monkeys
• Minhoo Kim, Ph.D., USC, Modeling ovarian aging heterogeneity

4:40 p.m. - 5:00 p.m.: Panel Discussion I – Heterogeneity in Aging: Challenges and Opportunities

• Moderator: George Kuchel, M.D.
• All speakers for Sessions I and II as panelists

5:00 p.m.: End of Day One

Day 2 (Tuesday, May 9, 2023)

10:00 a.m. - 10:05 a.m.: Summary of Day 1 and Goals for Day 2

10:05 a.m. - 12:10 p.m.: Session 3 | Selected Cohorts of Successful Aging

• Paola Sebastiani, Ph.D., Tufts University, Extreme human longevity cohorts
• Yousin Suh, Ph.D., Columbia University, Ovarian aging: A target for geroprotection in women
• Lauren Koch, Ph.D., University of Toledo, Rat models of exercise capacity: the energy transfer hypothesis
• John Thyfault, Ph.D., F.A.C.S.M., F.T.O.S., University of Kansas, Aerobic capacity drives risk for chronic metabolic disease
• Break (12:10 p.m. - 12:50 p.m.)

12:50 p.m. - 2:55 p.m.: Session 4 | Investigation of Successful Aging and Approaches to Interpret Heterogeneity

• Megan Huisingh-Scheetz M.D., M.P.H., University of Chicago, Assessing and managing heterogeneity in older adult clinical care: current challenges and future directions
• Trey Ideker, Ph.D., UCSD, Dissecting epigenetic measures of age
• Graham Ruby, Ph.D., Calico, Video and frailty: capturing the heterogeneity of aging in mice
• Robert Williams, Ph.D., University of Tennessee, Parsing the genetic and environmental heterogeneity of aging (successful or otherwise)
• Break (2:55 p.m. - 3:20 p.m.)

3:20 p.m. - 3:40 p.m.: Panel Discussion II – Experimental, Statistical, and Computational Approaches to Heterogeneity in Aging Research

• Moderator: Robert Williams, Ph.D.
• All speakers for Sessions III and IV as panelists

3:40 p.m. - 4:00 p.m.: Workshop Wrap-Up

• All speakers and NIA-DAB Leadership
• Final remarks and conclusion of the workshop

Workshop Recording

To request access to the workshop recording, contact Tiziana Cogliati.

Contact Information

Please contact Tiziana Cogliati for questions you may have about the workshop.