Workshop: Advances in Aging, Immunity, and Chronic Inflammatory Disease

Target Audience

Researchers at all career stages from academia, government, and industry with a shared interest in the fields of immunology and the biology of aging.

Dates

May 9, 2023
May 10, 2023

Location

6701 Rockledge Drive, Room 160
Bethesda, MD 20817

Purpose and Background

This workshop will focus on recent advances (biological and technological) in our knowledge of immunosenescence, aging, and their impact on chronic disease development. The past few years have seen major advances in our knowledge of immune function during aging, and improved methods to define immunological states. Notably, advances in single cell technologies have the potential to permit interrogation of metabolic and phenotypic variation of leukocytes, including rare tissue resident populations, and circadian gene regulation in macrophages. The workshop will highlight recent advances, clarify mechanisms involved in accelerated development of immune aging and chronic disease, and promote collaboration between investigators.

Registration

Register for this workshop

Agenda

Note: This agenda is in Eastern Daylight Time.

Day 1 (Tuesday, May 9, 2023)

9:00 a.m.: Introduction and Stage Setting

• Welcome, Mercy PrabhuDas, Ph.D, MBA, National Institute of Allergy and Infectious Diseases, Mulualem Tilahun, D.V.M., Ph.D., National Institute on Aging, and Preethi Chander, Ph.D., National Institute of Dental and Craniofacial Research
• Opening Remarks, Hugh Auchincloss, M.D., National Institute of Allergy and Infectious Diseases, Richard Hodes, M.D., National Institute on Aging, and Rena D'Souza, D.D.S., M.S., Ph.D., National Institute of Dental and Craniofacial Research
• Keynote 1: Human Immune Organoids to Analyze Vaccine Responses, Autoimmunity, and Aging, Mark Davis, Ph.D., Stanford University
• Q&A

10:20 a.m.: Session 1 | Dynamics of Resident Immune Cell Aging

• Stromal Cells and Aging, Emmanuelle Passegue, Ph.D., Columbia University
• Innate Lymphoid Cells in an Aged Microenvironment, Emily Goldberg, Ph.D., UCSF
• Neutrophil Aging Mechanisms, Tissue Pathology, and Sexual Dimorphism, Berenice Benayoun, Ph.D., USC

11:20 a.m.: Break

• Myeloid Cells, Inflammation, and Host Immune Responses, Maxim Artyomov, Ph.D., Washington University in St. Louis
• Aging in B Cells and Antibody Repertoires Across the Lifespan, Scott Boyd, M.D., Ph.D., Stanford University
• Age-Related T Cell Functional Changes, Jarrod Dudakov, Ph.D., Fred Hutch Cancer Center
• Gaps in the Field Discussion, Bonnie Blomberg, Ph.D., University of Miami

1:00 p.m.: Lunch Break & Poster Viewing

2:20 p.m.: Session 2 | Organ-Immune System Crosstalk in Health and Disease

• Impact of Aging on Chronic Inflammatory Disease: Oral-Systemic Aging, George Hajishengallis, D.D.S., Ph.D., University of Pennsylvania
• Lung Macrophages and Age-Related Risk of Acute and Chronic Lung Diseases, Scott Budinger, M.D., Northwestern University
• Inflammation, Aging, and Cardiovascular Disease, Daniel Goldstein, M.D., University of Michigan
• DNA Repair, Mitochondrial Dysfunction and T Cell Aging in Autoimmunity, Cornelia Weyand, M.D., Ph.D., Mayo Clinic
• Metabolic Programming Contribution in Aging, Marcia Haigis, Ph.D., Harvard University
• Gaps in the Field Discussion, Elizabeth Kovacs, Ph.D., University of Colorado

4:20 p.m.: Break

4:40 p.m.: Session 3 | Neuroimmune Pathways and Neurodegenerative Diseases (Part 1)

• Immune and Nervous System Interactions, Saul Villeda, Ph.D., UCSF
• BBB and Vascular Barrier Function, Hui Zheng, Ph.D., Baylor College of Medicine
• Improving Nerve Supply to Reverse Organ Aging in Salivary Gland, Sarah Knox, Ph.D., UCSF

5:40 p.m.: Adjourn Day One

Day 2 (Wednesday, May 10, 2023)

8:30 a.m.: Introduction to Day Two and Neuroimmune Pathways and Neurodegenerative Diseases (Part 2)

• Recap from Day One, Maja Maric, Ph.D., National Institute on Aging, and Christina Camell, Ph.D., University of Minnesota
• Innate Immune Responses and Neurological Disease, Katrin Andreasson, M.D., Stanford University
• Down Syndrome, Accelerated Aging, and Immune Dysregulation, Bernard Kohr, M.D., Ph.D., Benaroya Research Institute
• Gaps in the Field Discussion, Christina Camell, Ph.D., University of Minnesota

9:50 a.m.: Break

10:10 a.m.: Keynote 2

• Keynote 2 - Role of Senescent Cells in Age-Related Diseases, Laura Niedernhofer, M.D., Ph.D., University of Minnesota
• Q&A

10:40 a.m.: Session 4 | Immunometabolism (Part 1)

• Modulation of Diet and Impact on Immune Function, Vishwa Deep Dixit, D.V.M., Ph.D., Yale School of Medicine
• Mitochondrial Dysfunction and Senescence, Maria Mittelbrunn, Ph.D., Centro de Biología Molecular Severo Ochoa
• Immunological Clock, David Furman, Ph.D., Buck Institute for Research on Aging

11:40 a.m.: Break & Poster Viewing

1:10 p.m.: Session 4 | Immunometabolism (Part 2)

• Age-Related Immune Dysregulation, Arya Biragyn, Ph.D., National Institute on Aging
• Immunometabolic Regulation of Humoral Immunity, Daniela Frasca, Ph.D., University of Miami
• Gaps in the Field Discussion, Daniela Frasca, Ph.D., University of Miami, and Shannon Wallet, Ph.D., University of Florida

2:10 p.m.: Break

2:30 p.m.: Session 5 | Responses to Infections and Vaccines

• Effectiveness of Vaccines in Older Adults, Albert Shaw, M.D., Ph.D., Yale University
• How Aging Changes the Immune Response to Vaccination, Michelle Linterman, Ph.D., Cambridge University
• Development of Adjuvants for Improving Host Immune Responses, Ofer Levy, M.D., Ph.D., Boston Children’s Hospital

3:30 p.m.: Break

• Immune Resilience, Infection, and Inflammation, Sunil Ahuja, M.D., UT Health San Antonio
• Tissue Damage Response and Aging, Jennifer Elisseeff, Ph.D., Johns Hopkins University
• Epigenetic Regulation of T Cell Responses in Older Adults, Jorg Goronzy, M.D., Ph.D., Mayo Clinic
• Gaps in the Field Discussion, Bonnie Blomberg, Ph.D., University of Miami and Preethi Chander, Ph.D., National Institute of Dental and Craniofacial Research
• Closing Remarks, Mercy PrabhuDas, Ph.D, MBA, National Institute of Allergy and Infectious Diseases, Mulualem Tilahun, D.V.M., Ph.D., National Institute on Aging, and Preethi Chander, Ph.D., National Institute of Dental and Craniofacial Research

5:15 p.m.: Meeting Adjourns

Additional Information

This workshop will take place in advance of the American Association of Immunologists (AAI) annual meeting, which is scheduled from May 11-15, 2023 in Washington, DC. For more information on the AAI Annual Meeting, see the AAI conference website.

Contact Information

Please contact Mulualem Tilahun for questions you may have about the workshop.

Reasonable Accommodation: If you need reasonable accommodation to participate in this event, please contact the meeting organizer listed under Contact information. Please make your request no later than 1 week before the event.