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Virtual Workshop: Animals for Geroscience: Needs for Translational and Preclinical Research

Target audience

Researchers at all career stages from academia, government, and industry with a shared interest in geroscience, the biology of aging, animal models, veterinary medicine, preclinical and clinical research, and/or the translation of aging interventions.

Dates

October 6, 2022, 10 a.m. - 5:15 p.m. ET

October 7, 2022, 10 a.m. - 5 p.m. ET

Location

This workshop will be held virtually on zoom.

Purpose and Goals

The geroscience hypothesis posits that intervening in fundamental aging processes will delay the appearance and decrease the severity of adult-onset diseases and ameliorate age-related decline in function observed in human populations. Recently, there has been a great deal of attention on leveraging geroscience insights from the laboratory to develop anti-aging or ‘geroprotective’ therapies. In order to move potentially effective therapies toward the clinic, we must understand if we currently have the appropriate animal models to effectively translate geroscience findings into effective and safe therapies for humans. To begin to address that question, the Trans-NIH Geroscience Interest Group (GSIG) will host a virtual public workshop on the topic of Animal Models for Translational and Preclinical Geroscience Research on October 6-7, 2022.

This workshop will aim to gather background information on the use of animals in basic geroscience-focused research studies across academia, government, and industry settings. Speakers at the workshop will examine the challenges and opportunities with studying a variety of animal models for translational geroscience research and the development of interventions that target fundamental aging processes.

Workshop themes will include:

  • Current efforts in translational geroscience using laboratory mice, rats, domesticated animals, and non-human primates;
  • The application of comparative biology to gain new insights in geroscience;
  • The impact of nutrition and the microbiome in animal research;
  • New ways to utilize data from animals that are retired from research; and
  • An exploration of new and alternative models for translational geroscience.

Agenda

Note: This agenda is in Eastern Daylight Time.

Day 1 (Thursday, October 6, 2022)

10:00 a.m.-10:15 a.m.: Introduction

  • Welcome and Introduction to the Goals of the Workshop, Ronald Kohanski, Ph.D. and Siobhan Addie, Ph.D., National Institute on Aging

10:15 a.m.-11:40 a.m.: Session 1 | Setting the Stage

  • Keynote: Advantages and Disadvantages to Animals Frequently Studied in Biomedical Research, Caroline Zeiss, Ph.D., DACVP, DACLAM, Yale University School of Medicine
  • Keynote: Findings from 2021 NIH Workshop Series on Validation of Animal Models and Tools for Biomedical Research, Hugo J. Bellen, D.V.M., Ph.D., Baylor College of Medicine
  • Keynote: Ethical Issues Associated with the Study of Animal Models, Jeffrey Kahn, Ph.D., MPH, Johns Hopkins University
  • Q&A and Panel Discussion

12:00 p.m.-1:10 p.m.: Session 2 | Laboratory Mice and Rats as Tools for Translational Geroscience

  • Study of Longitudinal Aging in Mice (SLAM) Study: Documenting Changes in Mouse Physiology with Age, Rafael de Cabo, Ph.D., National Institute on Aging
  • Lessons from Mice and Rats That Can Inform Gerotherapeutic Development, Benjamin Miller, Ph.D., Oklahoma Medical Research Foundation
  • Rodent Models of Geropathology and Their Use in Translation, Jessica Snyder, D.V.M., M.S., University of Washington
  • Q&A and Panel Discussion

1:30 p.m.-2:25 p.m.: Session 3 | The Impact of Nutrition and the Microbiome on Translational Research Using Animals

2:45 p.m.-3:40 p.m.: Session 4 | Leveraging Comparative Biology for Studying Select Age-Related Conditions

  • Comparative Biology as a Tool to Better Understand Aging and Facilitate Translational Studies, Mary Ann Ottinger, Ph.D., University of Houston
  • Evolution and Comparative Biology of Aging and Longevity, Donna Holmes, Ph.D., M.S., University of Idaho
  • Q&A and Panel Discussion

3:40 p.m.-5:15 p.m.: Session 5 | Gaining New Insights about Geroscience from Non-Human Primates in Captive and Wild Settings

  • Using Information from a Unique Primate Radiation Survivor Core to Better Understand the Heterogeneity of Aging, J. Mark Cline, D.V.M., Ph.D., Wake Forest University School of Medicine
  • Exploring Aging in Primates in Natural Contexts, Amanda Melin, Ph.D., University of Calgary
  • Social and Environmental Effects on Aging in Amboseli Baboons, Elizabeth Archie, Ph.D., University of Notre Dame
  • Optimizing Geroscience Study Design in Nonhuman Primates, Julie Mattison, Ph.D., National Institute on Aging
  • Q&A and Panel Discussion

5:15 p.m.: End of Day One

Day 2 (Friday, October 7, 2022)

10:00 a.m.-10:10 a.m.: Welcome

  • Recap of Day One and Preview of Day Two, Evan Hadley, M.D., National Institute on Aging

10:10 a.m.-11:05 a.m.: Session 6 | Opportunities and Challenges with Utilizing Domesticated Animals for Translational Research in Geroscience

  • What Can We Learn About Translational Geroscience from Pet Dogs?, Kate Creevy, D.V.M., M.S., Texas A&M University
  • Promising Future Avenues and Potential Concerns for Aging Research in Companion Animals, Jessica Hoffman, Ph.D., Augusta University
  • Q&A and Panel Discussion

11:20 a.m.-1:05 p.m.: Session 7 | Exploring Pigs as a Model for Translational Geroscience Research

2:15 p.m.-3:35 p.m.: Session 8 | New and Alternative Models for Studying Translational Geroscience

  • Leveraging Heterochronic Parabiosis and Intestinal Organoids to Study Cell Non-Autonomous Mechanisms of Gut Aging, Derek Huffman, Ph.D., Albert Einstein College of Medicine
  • Humans are People Too: Utility of Primary Cell and Organoid Culture in Geroscience, Mark LaBarge, Ph.D., City of Hope
  • Exploring Musculoskeletal Aging and Physiology Using Organoids, Young Charles Jang, M.S., Ph.D., Georgia Tech
  • Q&A and Panel Discussion

3:55 p.m.-5:00 p.m.: Session 9 | Final Panel Discussion and Wrap-Up

Interactive Panel Discussion featuring:

Workshop Recording

Recordings from the virtual workshop are available below.

Workshop Day 1 (October 6, 2022)

 

 

Workshop Day 2 (October 7, 2022)

 

Contact Information

If you have any questions about the workshop, please contact Siobhan Addie.

Reasonable Accommodation: If you need reasonable accommodation to participate in this event, please contact the meeting organizer listed under Contact information. Please make your request no later than 1 week before the event.

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An official website of the National Institutes of Health