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NIA Caenorhabditis Intervention Testing Program (CITP) Announces a Call for Compounds to Test for Anti-Aging Activity in Caenorhabditis

The National Institute on Aging (NIA) Caenorhabditis Interventions Testing Program (CITP) was established to test compounds purported to extend lifespan and/or delay the onset of disease and disability. The NIA CITP aims to identify pharmacological interventions that increase lifespan and/or healthspan in a robust manner using a genetically diverse set of Caenorhabditis species and strains. The CITP is comprised of four major components—three screening centers and a data coordination center. The principal investigators at the three screening centers are (1) Monica Driscoll - Rutgers, The State University of New Jersey; (2) Patrick Phillips - University of Oregon; (3) Gordon Lithgow - Buck Institute. The data coordination center is also headed by Patrick Phillips at University of Oregon.

The CITP is a collaborative effort between the study sites and the compound nominators who recommend interventions for study. The compound nominator’s role is to provide the rationale for investigating the intervention(s) and make recommendations on the dose, route and timing for administration of the intervention, and propose assays and measurements to document the efficacy of the intervention. The compound nominator will have access to all data developed from the study, will assist in analysis of the data and will be a co-author on resulting publications. The compound nominators’ proposals for specific interventions are reviewed by an Access Panel and accepted proposals will be prioritized by the CITP Steering Committee.

All results of these studies will be published and the data publicly available. Any delays to publications will be reviewed by the CITP Steering Committee, whose decision will be final.

The NIA CITP is soliciting proposals for compounds to enter the study in 2020-2021. This is not a funding opportunity announcement, but rather a solicitation of nominations for compounds to be tested in the CITP. The first deadline for receipt of proposals is June 30, 2020. Information on the NIA CITP and guidelines for proposal development are posted on the NIA website (to be developed) and the CITP website. Proposals should be submitted electronically to Tracy Cope.

Please direct all inquiries to:

Max Guo, Ph.D.
National Institute on Aging
Telephone: 301-402-7747
Email Max Guo, Ph.D.