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Supported Interventions

Each compound is given in the diet at the following levels (part per million -ppm- which is defined as milligrams of agent per kilogram of food). All testing is Stage I unless otherwise indicated.

Compound Cohort Concentration in Food Age at Treatment Initiation Increase in Median (Med) and Maximum (Max) Lifespan
4-OH-a-phenyl-N-tert-butyl nitrone (4-OH-PBN) 2004 315 ppm 4 mo none
aspirin (Asp) 2004 20 ppm 4 mo Male (Med)
nitroflurbiprofen (NFP) 2004 200 ppm 4 mo none
nordihydroguaiaretic acid (NDGA) 2004 2500 ppm 9 mo Male (Med)
caffeic acid phenethyl ester (CAPE) 2005 30 ppm 4 mo none
caffeic acid phenethyl ester (CAPE) 2005 300 ppm 4 mo none
enalapril (Enal) 2005 120 ppm 4 mo none
rapamycin (Rapa) 2005 14 ppm 20 mo Male (Med, Max) & Female (Med, Max)
rapamycin (Rapa) 2006 14 ppm 9 mo Male (Med, Max) & Female (Med, Max)
resveratrol (Res) 2006 300 ppm 12 mo none
resveratrol (Res) 2006 1200 ppm 12 mo none
simvastatin (Sim) 2006 12 ppm 10 mo none
simvastatin (Sim) 2006 120 ppm 10 mo none
curcumin (Cur) 2007 2000 ppm 4 mo none
green tea extract (GTE) 2007 2000 ppm 4 mo none
medium-chain triglyceride oil (MCTO) 2007 60,000 ppm 4 mo none
oxaloacetic acid (OAA) 2007 2200 ppm 4 mo none
resveratrol (Res) 2007 300 ppm 4 mo none
17-a-estradiol (17aE2) 2009 4.8 ppm 10 mo Male (Med)
acarbose (ACA) 2009 1000 ppm 4 mo Male (Med, Max) & Female (Med, Max)
methylene blue (MB) 2009 28 ppm 4 mo none
rapamycin (Rapa) - Stage II 2009 4.7 ppm 9 mo Female (Med, Max)
rapamycin (Rapa) - Stage II 2009 14 ppm 9 mo Male (Med, Max) & Female (Med, Max)
rapamycin (Rapa) - Stage II 2009 42 ppm 9 mo Male (Med, Max) & Female (Med, Max)
fish oil (FO) 2010 15,000 ppm 9 mo none
fish oil (FO) 2010 50,000 ppm 9 mo none
nordihydroguaiaretic acid (NDGA) - Male only, Stage II 2010 800 ppm 6 mo Male (Med)
nordihydroguaiaretic acid (NDGA) - Male only, Stage II 2010 2500 ppm 6 mo Male (Med)
nordihydroguaiaretic acid (NDGA) - Stage II 2010 5000 ppm 6 mo Male (Med)
17-a-estradiol (17aE2) 2011 14 ppm 10 mo Male (Med, Max)
metformin (Met) 2011 1000 ppm 9 mo none
metformin and rapamycin (MetRapa) 2011 Met:1000 ppm and Rapa:14 ppm 9 mo Male (Med, Max) & Female (Med, Max)
Protandim (Prot) 2011 600 ppm then 1200 ppm 10 mo then 17 mo Male (Med)
ursodeoxycholic acid (UDCA) 2011 5000 ppm 5 mo none
2-(2-Hydroxyphenyl)benzoxazole (HBX) 2012 1 ppm 15 mo none
acarbose (ACA) 2012 1000 ppm 16 mo Male (Med, Max) & Female (Max)
INT-767 FXR/TGR5 agonist (INT-767) 2012 180 ppm 10 mo none
acarbose (ACA) - Stage II 2013 400 ppm 8 mo Male (Med, Max)
acarbose (ACA) - Stage II 2013 1000 ppm 8 mo Male (Med, Max) & Female (Med, Max)
acarbose (ACA) - Stage II 2013 2500 ppm 8 mo Male (Med, Max) & Female (Med)
ursolic acid (UA) 2013 2000 ppm 10 mo none
aspirin (Asp) 2014 60 ppm 11 mo none
aspirin (Asp) 2014 200 ppm 11 mo none
glycine (Gly) 2014 80,000 ppm 9 mo Male (Med, Max) & Female (Med)
inulin (Inu) 2014 600 ppm 11 mo none
TM5441 (TM5441) 2014 60 ppm 11 mo none
17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride (DMAG) 2015 30 ppm 6 mo none
b-guanidinopropionic acid (bGPA) 2015 3300 ppm 6 mo none
minocycline (Min) 2015 300 ppm 6 mo none
MitoQ (MitoQ) 2015 100 ppm 7 mo none
rapamycin (Rapa) - Stage II 2015 42 ppm 20 mo (stop at 23) Male (Med, Max)
rapamycin (Rapa) - Intermittent, Stage II 2015 42 ppm (every other month) 20 mo Male (Med, Max) & Female (Med, Max)
rapamycin (Rapa) - Stage II 2015 42 ppm 20 mo Male (Med, Max) & Female (Med, Max)
17-a-estradiol (17aE2) - Stage II 2016 14.4 ppm 16 or 20 mo Male (Med)
3-(3-hydroxybenzyl)-5-methylbenzo[d]oxazol-2(3H)-one (MIF098) 2016 240 ppm 8 mo none
canagliflozin (Cana) 2016 180 ppm 7 mo Male (Med, Max)
candesartan cilexetil (CC) 2016 30 ppm 7 mo none
geranylgeranyl acetone (GGA) 2016 600 ppm 9 mo none
nicotinamide riboside (NR) 2016 1000 ppm 8 mo none
Hydrogen Sulfide prodrug SG1002 2016 240 ppm 19 mo none
1,3-butanediol (BD) 2017 100,000 ppm 6 mo none
Captopril (Capt) 2017 180 ppm 5 mo Female (Med); Male Results Indeterminant
L-Leucine (Leu) 2017 40,000 ppm 5 mo none
PB125 2017 100 ppm 5 mo none
Sulindac (Sul) 2017 5 ppm 5 mo none
Syringaresinol (Syr) 2017 300 ppm 5 mo none
Rapamycin + Acarbose (RaAc) - Stage II 2017 Ra: 14.7 ppm and Ac: 1000 ppm 9 mo or 16 mo Male (Med, Max) & Female (Med, Max)
Fisetin (Fis) 2018 600 ppm 20 mo none
Fisetin (Fis) - Cycling 2018 600 ppm (3 days on/11 days off) 20 mo none
Hydrogen Sulfide prodrug SG1002 2018 240 ppm 18 mo none
Astaxanthin (Asta) 2019 4000 ppm 12 mo In Progress
Dimethyl Fumarate (DMF) 2019 120 ppm 9 mo or 16 mo In Progress
Meclizine (Mec) 2019 800 ppm 12 mo In Progress
Mycophenolic Acid (MPA) 2019 6.7 ppm 9 mo In Progress
4-Phenylbutyrate (PBA) 2019 1000 ppm 9 mo In Progress
Hydrogen Sulfide prodrug SG1002 2019 240 ppm 6 mo In Progress
16 alpha-hydroxyestradiol 2020 5 ppm 12 mo In Progress
2,4-Dinitrophenol (DNP) 2020 3 ppm 6 mo In Progress
Hydralazine 2020 30 ppm 6 mo In Progress
Hydralazine 2020 30 ppm 16 mo In Progress
Nebivolol 2020 60 ppm 6 mo In Progress
Sodium Thiosulfate (STS) 2020 10,000 ppm 6 mo In Progress
Canagliflozin (Cana) - Stage II 2020 180 ppm 16 mo In Progress
alpha-ketoglutarate (AKG) 2020 20,000 ppm 18 mo In Progress
2BAct (2BA) 2021 30 ppm 7 mo In Progress
Dichloroacetate (DCA) 2021 30 ppm 7 mo In Progress
Epicatechin (Epi) 2021 60 ppm 7 mo In Progress
Forskolin (For) 2021 5 ppm 7 mo In Progress
Halofuginone (Hal) 2021 0.6 ppm 7 mo In Progress
MSDC-160 (M160) 2021 300 ppm 7 mo In Progress
alpha-ketoglutarate (AKG) 2022 20,000 ppm 7 mo In Progress
Atorvastatin + Telmisartan (AtorTel) 2022 Ator: 120 ppm; Tel:30 ppm 7 mo In Progress
Metformin + Nicotinamide Riboside (Met + NR) 2022 Met: 1000 ppm; NR: 2400 ppm 20 mo In Progress
Methotrexate 2022 0.2 ppm 14 mo In Progress
Mifepristone (Mife) 2022 30 ppm 7 mo In Progress
Pioglitazone (Pio) 2022 100 ppm 7 mo In Progress
Captopril (Capt) 2022 TBD TBD In Progress
Meclizine (Mec) 2022 2400 ppm 16 mo In Progress
Meclizine (Mec) - Males only 2022 800 ppm 16 mo In Progress
Astaxanthin (Asta) 2022 800 ppm 11 mo In Progress
Astaxanthin (Asta) - Males only 2022 800 ppm 16 mo In Progress
TPPU 2023 24 ppm 7 mo In Progress
Rapamycin and 17-alpha Estradiol (Rapa_17aE) 2023 TBD TBD In Progress
Canagliflozin (Cana) 2023 180 ppm 7 mo until 20 mo In Progress
Canagliflozin (Cana) 2023 60 ppm 7 mo In Progress
Sodium Thiosulfate (STS) 2023 3,333 ppm 7 mo In Progress

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