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Supported Interventions

Each compound is given in the diet at the following levels (part per million -ppm- which is defined as milligrams of agent per kilogram of food). All testing is Stage I unless otherwise indicated.

Compound Cohort Concentration in Food Age at Treatment Initiation Increase in Lifespan
4-OH-a-phenyl-N-tert-butyl nitrone (4-OH-PBN) 2004 315 ppm 4 mo none
aspirin (Asp) 2004 20 ppm 4 mo Male
nitroflurbiprofen (NFP) 2004 200 ppm 4 mo none
nordihydroguaiaretic acid (NDGA) 2004 2500 ppm 9 mo Male
caffeic acid phenethyl ester (CAPE) 2005 30 ppm 4 mo none
caffeic acid phenethyl ester (CAPE) 2005 300 ppm 4 mo none
enalapril (Enal) 2005 120 ppm 4 mo none
rapamycin (Rapa) 2005 14 ppm 20 mo Male & Female
rapamycin (Rapa) 2006 14 ppm 9 mo Male & Female
resveratrol (Res) 2006 300 ppm 12 mo none
resveratrol (Res) 2006 1200 ppm 12 mo none
simvastatin (Sim) 2006 12 ppm 10 mo none
simvastatin (Sim) 2006 120 ppm 10 mo none
curcumin (Cur) 2007 2000 ppm 4 mo none
green tea extract (GTE) 2007 2000 ppm 4 mo none
medium-chain triglyceride oil (MCTO) 2007 60,000 ppm 4 mo none
oxaloacetic acid (OAA) 2007 2200 ppm 4 mo none
resveratrol (Res) 2007 300 ppm 4 mo none
17-a-estradiol (17aE2) 2009 4.8 ppm 10 mo Male
acarbose (ACA) 2009 1000 ppm 4 mo Male
methylene blue (MB) 2009 28 ppm 4 mo none
rapamycin (Rapa) - Stage II 2009 4.7 ppm 9 mo Male & Female
rapamycin (Rapa) - Stage II 2009 14 ppm 9 mo Male & Female
rapamycin (Rapa) - Stage II 2009 42 ppm 9 mo Male & Female
fish oil (FO) 2010 15,000 ppm 9 mo none
fish oil (FO) 2010 50,000 ppm 9 mo none
nordihydroguaiaretic acid (NDGA) - Male only, Stage II 2010 800 ppm 6 mo Male
nordihydroguaiaretic acid (NDGA) - Male only, Stage II 2010 2500 ppm 6 mo Male
nordihydroguaiaretic acid (NDGA) - Stage II 2010 5000 ppm 6 mo Male
17-a-estradiol (17aE2) 2011 14 ppm 10 mo Male
metformin (Met) 2011 1000 ppm 9 mo none
metformin and rapamycin (MetRapa) 2011 Met:1000 ppm and Rapa:14 ppm 9 mo Male & Female
Protandim (Prot) 2011 600 ppm then 1200 ppm 10 mo then 17 mo Male
ursodeoxycholic acid (UDCA) 2011 5000 ppm 5 mo none
2-(2-Hydroxyphenyl)benzoxazole (HBX) 2012 1 ppm 15 mo  
acarbose (ACA) 2012 1000 ppm 16 mo Male
INT-767 FXR/TGR5 agonist (INT-767) 2012 180 ppm 10 mo none
nordihydroguaiaretic acid (NDGA) - Male only, Cross-Section 2012 2500 ppm 13 mo Male
nordihydroguaiaretic acid (NDGA) - Female only, Cross-Section 2012 5000 ppm 13 mo none
acarbose (ACA) - Stage II 2013 400 ppm 8 mo Male
acarbose (ACA) - Stage II 2013 1000 ppm 8 mo Male
acarbose (ACA) - Stage II 2013 2500 ppm 8 mo Male
ursolic acid (UA) 2013 2000 ppm 10 mo none
aspirin (Asp) 2014 60 ppm 11 mo none
aspirin (Asp) 2014 200 ppm 11 mo none
glycine (Gly) 2014 80,000 ppm 9 mo none
inulin (Inu) 2014 600 ppm 11 mo none
TM5441 (TM5441) 2014 60 ppm 11 mo none
17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride (DMAG) 2015 30 ppm 6 mo none
b-guanidinopropionic acid (bGPA) 2015 3300 ppm 6 mo none
minocycline (Min) 2015 300 ppm 6 mo none
MitoQ (MitoQ) 2015 100 ppm 7 mo none
rapamycin (Rapa) - Stage II 2015 42 ppm 20 mo (stop at 23) Male
rapamycin (Rapa) - Intermittent, Stage II 2015 42 ppm (every other month) 20 mo Male & Female
rapamycin (Rapa) - Stage II 2015 42 ppm 20 mo Male & Female
17-a-estradiol (17aE2) - Stage II 2016 14.4 ppm 16 or 20 mo none
3-(3-hydroxybenzyl)-5-methylbenzo[d]oxazol-2(3H)-one (MIF098) 2016 240 ppm 8 mo none
canagliflozin (Cana) 2016 180 ppm 7 mo Male
candesartan cilexetil (CC) 2016 30 ppm 7 mo none
geranylgeranyl acetone (GGA) 2016 600 ppm 9 mo none
nicotinamide riboside (NR) 2016 1000 ppm 8 mo none
Hydrogen Sulfide prodrug SG1002 2016 240 ppm 19 mo none
1,3-butanediol (BD) 2017 100,000 ppm 6 mo none
Captopril (Capt) 2017 180 ppm 5 mo Female
L-Leucine (Leu) 2017 40,000 ppm 5 mo none
PB125 2017 100 ppm 5 mo none
Sulindac (Sul) 2017 5 ppm 5 mo none
Syringaresinol (Syr) 2017 300 ppm 5 mo none
Rapamycin + Acarbose (RaAc) - Stage II 2017 Ra: 14.7 ppm and Ac: 1000 ppm 9 mo or 16 mo Male & Female
Fisetin (Fis) 2018 600 ppm 20 mo none
Fisetin (Fis) - Cycling 2018 600 ppm (3 days on/11 days off) 20 mo none
Hydrogen Sulfide prodrug SG1002 2018 240 ppm 18 mo none
Astaxanthin (Asta) 2019 4000 ppm 12 mo In Progress
Dimethyl Fumarate (DMF) 2019 120 ppm 9 mo or 16 mo In Progress
Meclizine (Mec) 2019 800 ppm 12 mo In Progress
Mycophenolic Acid (MPA) 2019 6.7 ppm 9 mo In Progress
4-Phenylbutyrate (PBA) 2019 1000 ppm 9 mo In Progress
Hydrogen Sulfide prodrug SG1002 2019 240 ppm 6 mo In Progress
16 alpha-hydroxyestradiol 2020 5 ppm 12 mo In Progress
2,4-Dinitrophenol (DNP) 2020 3 ppm 6 mo In Progress
Hydralazine 2020 30 ppm 6 mo In Progress
Nebivolol 2020 60 ppm 6 mo In Progress
Sodium Thiosulfate (STS) 2020 10,000 ppm 6 mo In Progress
Canagliflozin (Cana) - Stage II 2020 180 ppm 16 mo In Progress

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