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Publications from the NIA Interventions Testing Program

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Warner, H. R., Ingram, D., Miller, R. A., Nadon, N. L. and Richardson, A. G. 2000. Meeting Report: Program for testing biological interventions to promote healthy aging. Mechanisms of Aging and Development 115:199-208. [PMID 10906513]

Miller, R. A., Harrison, D. E., Astle, C. M., Floyd, R. A., Flurkey, K., Hensley, K. L., Javors, M. A., Leeuwenburgh, C., Nelson, J. F., Ongini, E., Nadon, N. L., Warner, H. R., and Strong, R. 2007. NIA Interventions Testing Program: Study Design and an Interim Report. Aging Cell 6:565-575. [PMID 17578509; PMC2695675]

Nadon, N. L., Strong, R., Miller, R. A., Nelson, J., Javors, M., Sharp, Z. D., Peralba, J. M. and Harrison, D. E. 2008. Design of Aging Intervention Studies: the NIA Interventions Testing Program. 2008. Age 30:187-199. Nadon NL, Strong R, Miller RA, Nelson J, Javors M, Sharp ZD, Peralba JM, Harrison DE. Design of aging intervention studies: the NIA interventions testing program. Age (Dordr) 30(4):187-99. doi: 10.1007/s11357-008-9048-1. [PMID 19424842; PMCID PMC2585647]

Strong, R., Miller, R. A., Astle, C. M., Floyd, R. A., Flurkey K., Hensley, K. L., Javors, M. A., Leeuwenburgh, C., Nelson, J. F., Ongini, E., Nadon, N. L., Warner, H. R., and Harrison, D. E. 2008. Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell 7:641-650. [PMID 18631321]

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., Pahor, M., Javors, M. A., Fernandez, E. and Miller, R. A. 2009. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460:392-395. [PMID 19587680]

Miller, R. A., Harrison, D., Astle, C. M., Baur, J. A., deCabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., Pletcher, S., Sharp, Z. D., Sinclair, D., Starnes, J. W., Wilkinson, J. E., Nadon, N. L., Strong, R. 2011. Rapamycin, But Not Resveratrol or Simvastatin, Extends Lifespan of Genetically Heterogeneous Mice. J. Gerontology, Biological Sciences 66A:191-201. [PMID 20974732]

Wilkinson, J. E., Burmeister, L., Brooks, S. V., Carames, B., Friedline, S., Harrison, D., Lotz, M., Nadon, N., Strong, R., Wood, L. K., Woodward, M. A., and Miller, R. A. Rapamycin Slows Aging in Mice. 2012. Aging Cell 11:675-682. [PMID 22587563]

Strong, R., Miller, R. A., Astle, C. M., Baur, J. A., de Cabo, R., Fernandez, E., Guo, W., Javors, M., Kirkland, J. L., Nelson, J. F., Sinclair, D., Teter, B., Williams, D., Zaveri, N., Nadon, N. L., Harrison, D. E. 2013. Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium chain triglyceride oil on lifespan of genetically heterogeneous mice. J. Gerontology, Biological Sciences 68:6-16. [PMID 22451473]

Miller, R. A., Harrison, D. E., Astle, C. M., Fernandez, E., Flurkey, K., Han, M., Javors, M. A., Li, X., Nadon, N. L., Nelson, J. F., Pletcher, S., Salmon, A. B., Sharp, Z. D., Van Roekel, S., Winkleman, L., Strong, R. Rapamycin-Mediated Lifespan Increase in Mice is Dose and Sex-Dependent and Metabolically Distinct from Dietary Restriction. 2014. Aging Cell 13:468-477. doi: 10.1111/acel.12194. [PMID 24341993]

Harrison D. E., Strong R., Allison, D. B., Ames, B. N., Astle, C. M., Atamna, H., Fernandez, E., Flurkey, K., Javors, M. A., Nadon, N. L., Nelson, J. F., Simpkins, J. W., Smith, D., Wilkinson, J. E., and Miller, R. A. Acarbose, 17-α-Estradiol, and Nordihydroguaiaretic Acid Extend Mouse Lifespan Preferentially in Males. [2014] Aging Cell 13:273-282. DOI: 10.1111/acel.12170. [PMID 24245565]

Nadon, N. L., R. A. Miller, R. Strong, and D. E. Harrison. NIA Interventions Testing Program: a collaborative approach for investigating interventions to promote healthy aging. Handbook of the Biology of Aging, 8th Edition. Eds: M. R. Kaeberlein and G. M. Martin. Chapter 10, pages 288 - 303, 2015. Academic Press.

Strong, R., Miller, R. A., Antebi, A., Astle, C. M., Bogue, M., Denzel, M. S., Fernandez, E., Flurkey, K., Hamilton, K. L., Lamming, D. W., Javors, M. A., de Magalhães, J. P., McCord, J. M., Miller, B. F., Müller, M., Nelson, J. F., Ndukum, J., Rainger, G. E., Richardson, A., Sabatini, D. M., Salmon, A. B., Simpkins, J. W., Steegenga, W. T., Nadon, N. L., Harrison, D. E. 2016. Longer lifespan in male mice treated with a weakly-estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer. Aging Cell 15:872-84 DOI: 10.1111/acel.12496.

Nadon, N. L., Strong, R., Miller, R. A., Harrison, D. E. 2016. NIA Interventions Testing Program: Investigating putative aging interventions agents in a genetically heterogeneous mouse model. eBioMedicine PII: S2352-3964(16)30554-0. DOI: 10.1016/j.ebiom.2016.11.038. online

Smith, B. J., R. A. Miller, A. C. Ericsson, D. E. Harrison, R. Strong, T. M. Schmidt. 2019. Changes in the gut microbiome and fermentation products concurrent with enhanced longevity in acarbose-treated mice. bioRxiv 311456; DOI: 10.1186/s12866-019-1494-7 BMC Microbiology 19:130. PMID: 31195972. PMC6567620.

Harrison D. E., Strong R., Alavez S., Astle C. M., DiGiovanni J., Fernandez E., Flurkey K., Javors M. A., Levi M., Lithgow J. G., Macchiarini F., Nelson J. F., Sukoff Rizzo S. J., Slaga T. J., Stearns T., Wilkinson J. E., Miller R. A. 2019. Acarbose improves health and lifespan in aging HET3 mice. Aging Cell 18(2):e12898. doi: 10.1111/acel.12898. [PMID 30688027; PMCID PMC6413665]

Miller R.A., Harrison D.E., Astle C.M., Bogue M.A., Brind J., Fernandez E., Flurkey K., Javors M., Ladiges W., Leeuwenburgh C., Macchiarini F., Nelson J., Ryazanov A.G., Snyder J., Stearns T.M., Vaughan D.E., Strong R. 2019. Glycine supplementation extends lifespan of male and female mice. Aging Cell 18(3):e12953. doi: 10.1111/acel.12953 [PMID 30916479; PMCID PMC6516426]

Strong R., Miller R.A., Bogue M.A., Fernandez E., Javors M., Libert S., Marinez P.A., Murphy M.P., Musi N., Nelson J. F., Petrascheck M., Reifsnyder P., Richardson A., Salmon A.B. Macchiarini F., Harrison D.E. 2020. Rapamycin-mediated mouse lifespan extension: late-life dosage regimes with sex-specific effects. Aging Cell 19(11):e13269. doi: 10.1111/acel.13269. [PMID 33145977; PMCID PMC7681050]

Miller R.A., Harrison D.E., Allison D.B., Bogue M., Debarba L., Diaz V., Fernandez E., Galecki A., Garvey W.T., Jayarathne H., Kumar N., Javors M.A., Ladiges W.C., Macchiarini F., Nelson J., Reifsnyder P., Rosenthal N.A., Sadagurski M., Salmon A.B., Smith D.L., Jr., Snyder J.M., Lombard D.B., Strong R. 2020. Canagliflozin Extends Lifespan in Genetically Heterogeneous Male But Not Female Mice. JCI Insight 5(21): e140019. doi: 10.1172/jci.insight.140019. [PMID 32990681; PMCID PMC7710304]

Harrison D.E., Strong, R., Reifsnyder P., Kumar N., Fernandez E, Flurkey K., Javors M.A., Lopez-Cruzan M., Macchiarini F., Nelson J.F., Bitto A., Sindler A.L., Cortopassi G., Kavanagh K., Leng L., Bucala R, Rosenthal N., Salmon A., Stearns T.M., Bogue M., Miller R.A. 2021. 17-a-estradiol late in life extends lifespan in aging UM-HET3 male mice; four other drugs do not affect lifespan in either sex. Aging Cell 20(5):e13328. doi: 10.1111/acel.13328. [PMID 33788371; PMCID PMC8135004]

Macchiarini F., Miller R.A., Strong R., Rosenthal N., Harrison D.H. NIA Interventions Testing Program: a collaborative approach for investigating interventions to promote healthy aging. Handbook of the Biology of Aging, 9th Edition. Eds: P.J. Hornsby P. J. and N. Musi. Chapter 10, pages 219 - 235, 2021. Academic Press.


Pazdro R., Harrison D.E. 2013. Murine adipose tissue-derived stromal cell apoptosis and susceptibility to oxidative stress in vitro are regulated by genetic background. PLoS One 8: e61235. [PMCID PMC3617166]

Lamming D.W., Ye L., Astle C.M., Baur J.A., Sabatini D.M., Harrison D.E. 2013. Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive. Aging Cell 12:712-18. [PMCID PMC3727050]

Ye L., Widlund A.L., Sims C.A., Lamming D.W., Guan Y., Davis J.G., Sabatini D.M., Harrison D.E., Vang O., Baur J.A. 2013. Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance. Aging 5(7):539-50. [PMCID PMC3765582]

Zhou Y., Harrison D.E., Love-Myers K., Chen Y., Grider A., Wickwire K., Burgess J.R., Stochelski M.A., Pazdro R. 2014. Genetic Analysis of Tissue Glutathione Concentrations and Redox Balance. Free Radic. Biol. Med. 71:157-64.

Chu H.P., Liao Y., Novak J.S., Hu Z., Merkin J.J., Shymkiv Y., Braeckman B.P., Dorovkov M.V., Nguyen A., Clifford P.M., Nagele R.G., Harrison D.E., Ellis R.E., Ryazanov A.G. 2014. Germline Quality Control: eEF2K Stands Guard to Eliminate Defective Oocytes. Dev. Cell. 2014 28:561-72. doi: 10.1016/j. devcel.2014. 01.027

Harrison D.E., Astle C.M., Niazi M.K.K., Major S., Beamer G.L. 2014, Genetically diverse mice are novel and valuable models of age-associated susceptibility to Mycobacterium tuberculosis. Immun. Aging 11:24. doi: 10.1186/s12979-014-0024-6. eCollection [PMID 25606048]

Yuan R., Gatti E.M.; Krier R., Malay E., Schultz D., Peters L.L., Churchill G.A., Harrison D.E., Paigen B. 2015. Genetic Regulation of Female Sexual Maturation and Longevity Through Circulating IGF1. J. Gerontol. A. Biol. Sci. Med. Sci. 70:817-26; 
 doi: 10.1093/gerona/glu114. Epub 2014 Jul 28. [PMID 25070661]

Reifsnyder P.C., Doty R., Harrison D.E. 2015. Rapamycin Ameliorates Nephropathy Despite Elevating Hyperglycemia in a Polygenic Mouse Model of Type 2 Diabetes, NONcNZO10/LtJ. 2014. PLoS One Dec 4;9(12):e114324. doi: 10.1371/journal.pone.0114324. eCollection. Erratum in: PLoS One 2015;10(3):e0119748 . [PMID 25473963]

Gong H., Qian H., Ertl R.P., Astle M.C., Wang G.G., Harrison D.E., Xu X. 2015. P, dietary restriction and rapamycin treatment in mouse brain. Oncotarget 6:15882-90. [PMID 26021816]

Thompson A.C., Bruss M.D., Price J.C., Khambatta C.F., Holmes W.E., Colangelo M., Dalidd M., Roberts L.S., Astle C.M., Harrison D.E., Hellerstein M.K. 2016. Reduced in vivo proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice. Aging Cell 15:118-27. doi: 10.1111/acel.12414. Epub 2015 Nov 6. [PMID 26541492]

Lee B.P., Pilling L.C., Emond F., Flurkey K., Harrison D.E., Yuan R., Peters L.L., Kuchel G.A., Ferrucci L., Melzer D., Harries L.W. 2016. Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans . Aging Cell 15:903-13. doi: 10.1111/acel.1

Jiang Z., Harrison D.E., Parsons M.E., McClatchy S., Jacobs L., Pazdro R. 2016. Heritability of in vitro phenotypes exhibited by murine adipose-derived stromal cells. Mamm. Genome 27: 460-468 DOI 10.1007/s00335-016-9655-6

Reifsnyder P.C., Flurkey K., Te A., Harrison D.E., 2016. Rapamycin treatment benefits glucose metabolism in mouse models of type 2 diabetes. Aging 8:3120-3130. doi: 10.18632/aging.101117

Lee B.P., Buric I., George-Pandeth A., Flurkey K., Harrison D.E., Yuan R., Peters L.L., Kuchel G.A., Melzer D., Harries L.W. 2017. MicroRNAs miR-203-3p, miR-664-3p and miR-708-5p are associated with median strain lifespan in mice. Nature Sci. Rep. 7:44620. doi: 10.1038/srep44620. [PMID 28304372]

Reifsnyder P.C., Ryzhov S., Flurkey K., Anunciado-Koza R.P., Mills I., Harrison D.E., Koza, R.A. 2017. Cardioprotective effects of dietary rapamycin on adult female C57BLKS/J-Leprdb mice. Annals NY Acad. Sci. 10-31-17. 1418(1):106-117. doi: 10.1111/nyas.13557. [PMID 29377150 PMCID PMC5934313]

Reifsnyder P.C., Te A., Harrison D.E.2019. Differential effects of rapamycin on glucose metabolism in 9 inbred strains. J. Gerontol. A. Biol. Sci. Med. Sci. pii: glz157. doi: 10.1093/gerona/glz157. [Epub ahead of print] [PMID 31276577; PMCID PMC6909913]

Yuan R., Musters C.J.M., Zhu Y., Evans T.R., Sun Y., Chesler E.J., Peters L.L., Harrison D.E., Bartke A. 2020. Genetic differences and longevity-related phenotypes influence lifespan and lifespan variation in a sex-specific manner in mice. Aging Cell e13263. doi: 10.1111/acel.13263


Steinbaugh, M. J., L. Y. Sun, A. Bartke, and R. A. Miller. 2012. Activation of genes involved in xenobiotic metabolism: a shared signature in mouse models of extended longevity. Am. J. Physiol.— Endocrinology and Metabolism 303: E488 – E495. [PMC3423099]

Hinojosa, C. A., V. E. Mgbemena, S. Friedline, S. N. Austad, R. A. Miller, S. Bose, C. J. Orihuela. 2012. Enteric-delivered rapamycin enhances resistance of aged mice to pneumococcal pneumonia through reduced cellular senescence. Exp. Gerontol. 47:958-965. [PMC3490008]

Lombard, D. B., and R. A. Miller. 2014. Aging, disease and longevity in mice. Ann. Rev. Gerontol. Geriatr. 34: 93- 38.

Pickering, A. M., M. Lehr, and R. A. Miller. 2015. Mouse and primate lifespan is correlated with immunoproteasome expression. J. Clin. Invest. 125:2059-2068. [PMID 25866968; PMC4463211]

Ma, S., S. H. Yim, S. G. Lee, E. B. Kim, S.-R. Lee, K.-T. Chang, R. Buffenstein, T. J. Park, R. A. Miller, C B. Clish, V. N. Gladyshev. 2015. Organization of the mammalian metabolome according to organ function, lineage specialization and longevity. Cell Metab. 22:332-343. [PMID 26244935]

Richardson A., K. E. Fischer, J. R. Speakman, R. de Cabo, S. J. Mitchell, C. A. Peterson, P. Rabinovitch, Y., A. Chiao, G. Taffet, R. A. Miller, R. C. Rentería, J. Bower, D. K. Ingram, W. C. Ladiges, Y. Ikeno, F. Sierra, S. N. Austad. 2016. Measures of healthspan as indices of aging in mice - A recommendation. J. Gerontol. A. Biol. Sci. Med. Sci. 71:427-430. [PMID 26287941]

Zaseck, L. W., R. A. Miller, and S. V. Brooks. 2016. Rapamycin attenuates age-associated changes in tibialis anterior tendon viscoelastic properties. J. Gerontol. Biol. Sci. doi: 10.1093/gerona/glv307. [PMID 26809496]

Dominick, G., J. Bowman, X. Li, R. A. Miller and G. Garcia. 2016. mTOR signaling regulates DNA damage response through the CCR4-NOT complex in long-lived Snell Dwarf, GHRKO and PAPPA-KO mice. Aging Cell doi: 10.1111/acel.12525. [PMID 27618784]

Bajwa, P., P. B. Nagendra, S. Nielsen, A. Bielanowicz, J. M. Lombard, J. E. Wilkinson, M. Serrano, R. A. Miller, P. S. Tanwar. 2016. Age related increase in mTOR activity contributes to the pathological changes in ovarian surface epithelium. 2016. Oncotarget doi: 10.18632/oncotarget.8468. [PMID 27036037]

Miller, R. A. 2016. Not your father's (or mother's) rodent: moving beyond B6. Neuron

Lombard, D. B., R. A. Miller, and S. D. Pletcher. 2017. Biology of Aging and Longevity. Hazzard's Geriatric Medicine and Gerontology, 7th Edition. Eds: J. B. Halter, J. G. Ouslander, S. Studenski, K. P. High, S. Asthana, M. A. Supiano, C. Ritchie. Chapter 1, pages 3 - 24. McGraw-Hill, New York.

Berkowitz, B.A., R. A. Miller, and R. Roberts. 2017. Genetically heterogeneous mice show age-related vision deficits not related to increased rod cell L-type calcium channel function in vivo. Neurobiol. Aging 49:198-203. [PMID 27823846; PMC5154834]

Sadagurski, M., G. Cady, and R. A. Miller. 2017. Anti-aging drugs reduce hypothalamic inflammation in a sex-specific manner. Aging Cell 16:652-660. [PMID 28544365; PMC5506421]

Bajwa, P., S. Nielsen, J. M. Lombard, L. Rassam, P. Nahar, B. Rueda, J. Erby Wilkinson, R. A. Miller, P. S. Tanwar. 2017. Overactive mTOR signaling leads to endometrial hyperplasia in aged women and mice. Oncotarget 8:7265-7275. [PMID 27980219; PMC5352319]

Garratt, M., B. Bower, G. G. Garcia, R. A. Miller. 2017. Sex-differences in lifespan-extension with acarbose and 17-α estradiol: gonadal hormones underlie male-specific improvements in glucose tolerance and mTORC2 signaling. Aging Cell 16:1256-1266. doi: 10.1111/acel.12656. [PMID 28834262; PMC5676051]

Bielas, J. A. Herbst, K. Widjaja, J. Hui, J. M. Aiken, D. McKenzie, R. A. Miller, S. Brooks, J. Wanagat. 2018. Long term rapamycin treatment improves mitochondrial DNA quality control in aging mice. Exp. Gerontol. 106:125-131. doi: 10.1016/j.exger.2018.02.021. [PMID: 29486228; PMCID: PMC5911406]

Garratt, M., K.A. Lagerborg, Y.-M. Tsai, A. Galecki, M. Jain, R. A. Miller. 2018. Male lifespan extension with 17-α estradiol is linked to a sex-specific metabolomic response modulated by gonadal hormones in mice. Aging Cell 17:e12786. DOI: 10.1111/acel.12786. [PMID 29806096]

Altschuler, R., A. Kanicki, C. Martin, D. C. Kohrman, and R. A. Miller. 2018. Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse cochlea. Hearing Research 370:11-15. [PMID 30245283; PMC6240471]

Tyshkovskiy, A., A. A. Borodinova, G. P. Ables, M. Garratt, P. Khaitovich, R. A. Miller, V. N. Gladyshev. 2019. Identification and application of gene expression signatures of lifespan-extending interventions. Cell Metabolism, DOI:10.1016/j.cmet.2019.06.018. [PMID 31353263; PMC6907080]

Garratt, M., D. Leander, K. Pifer, B. Bower, J. J. Herrera, S. M. Day, O. Fiehn, S. V. Brooks, R. A. Miller. 2019. 17-α estradiol ameliorates age-associated sarcopenia and improves late life physical function in male mice but not in females or castrated males. Aging Cell, DOI: 10.1111/acel.12920. [PMID 30740872; PMC6413653]

Reid, J. J., M. A. Linden, F. F. Peelor III, R. A. Miller, K. L. Hamilton, and B. F. Miller. 2019. Brain protein synthesis rates in the UM-HET3 mouse following treatment with rapamycin or rapamycin with metformin. J. Gerontol. Biol. Sci doi: 10.1093/gerona/glz069. [PMID 30864661]

Mau, T., M. O’Brien, A. K. Ghosh, R. A. Miller, and R. Yung. 2020. Lifespan extension drug interventions affect adipose tissue inflammation in aging. J. Gerontol. Biol. Sci. 75(1):89-98. doi: 10.1093/gerona/glz177. [PMID 31353414; PMC6909899]

Ewart, D., L. Harper, A. Gravely, R. A. Miller, C. S. Carlson, R.F. Loeser. 2020. Naturally occurring osteoarthritis in male mice exposed to drugs that extend lifespan. Connective Tissue Research 61:95 - 103. doi:10.1080/03008207.2019.1635590. [PMID 31530037; PMC6884676]

Endicott, S. J., Z. J. Ziemba, L. J. Beckmann, D. N. Boynton, and R. A. Miller. 2020. Inhibition of class I PI3K enhances chaperone-mediated autophagy. J. Cell Biol. 219 (12): e202001031. [PMID 33048163; PMC7557678]

Herrera, J. J., Louzon S., Pifer K., Leander D., Merrihew G., Szczesniak K., Whitson J., Wilkinson J. E., Fiehn O., MacCoss M., Day S.M., Miller R.A., Garratt M. 2020. Acarbose has sex-dependent and independent effects on age-related physical function, cardiac health and lipid biology. JCI Insight 137474. doi: 10.1172/jci.insight.137474. [PMID 32990683; PMC7710286]

Smith, B. J., Miller R.A., Schmidt T.M. 2020. Muribaculaceae genomes assembled from metagenomes suggest genetic drivers of differential response to acarbose treatment in mice. BioRxiv doi:

Shen, Z., Hinson A., Miller R.A., Garcia G.G. 2021. Cap-independent translation: a shared mechanism for lifespan extension by rapamycin, acarbose, and 17a-estradiol. Aging Cell 20(5):e13345. doi: 10.1111/acel.13345. [PMID 33742521; PMC8135077]

Lu, Y.-X., Regan J.C., Eber J., Drews L.F., Weinseis T., Stinn J., Hahn O., Miller R.A., Grönke S., Partridge L. 2021. A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to promote healthy longevity. eLife 10:e62233. [PMID 33988501; PMC8186904]

Debarba, L. K., Jayarathne H., Miller R.A., Garratt M., Sadagurski M. 2021. 17-α estradiol has sex-specific effects on neuroinflammation that are partly reversed by gonadectomy. J. Gerontol. Biol. Sci., in press. [PMID 34309657]

Korfhage, J., M. E. Skinner, J. Basu, J. K. Greenson, R. A. Miller, D. B. Lombard. 2021. Canagliflozin increases adenoma burden in female APCMin/+ mice.

BiRxiv. doi: 10.1093/gerona/glab254. PMID: 34448851.

Sato, T., J. Shapiro, H.-C. Chang, R. A. Miller, H. Ardehali. Aging is associated with increased brain iron through brain-derived hepcidin expression. eLife 11:e73456.


Majumder S., Caccamo A., Medina D.X., Benavides A.D., Javors M.A., Kraig E., Strong R., Richardson A., Oddo S. 2012. Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling. Aging Cell 11:326-35. doi: 10.1111/j.1474-9726.2011.00791. x. Epub 2012 Feb 1. [PMID 22212527]

Ramos F.J., Chen S.C., Garelick M.G., Dai D.F., Liao C.Y., Schreiber K.H., MacKay V.L., An E.H., Strong R., Ladiges W.C., Rabinovitch P.S, Kaeberlein M., Kennedy B.K. 2012. Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival. Sci. Transl. Med. 4:144ra103. doi: 10.1126/scitranslmed.3003802. [PMID 22837538]

Halloran J., Hussong S.A., Burbank R., Podlutskaya N., Fischer K.E., Sloane L.B., Austad S.N., Strong R., Richardson A., Hart M.J., Galvan V. 2012. Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice. Neuroscience 223:102-13. doi: 10.1016/j.neuroscience.2012.06.054. Epub 2012 Jun 28. [PMID 22750207]

Livi C.B., Hardman R.L., Christy B.A., Dodds S.G., Jones D., Williams C., Strong R., Bokov A., Javors M.A., Ikeno Y., Hubbard G., Hasty P., Sharp Z.D. 2013. Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors. Aging 5:100-10. [PMID 23454836]

Lin A.L., Zheng W., Halloran J.J., Burbank R.R., Hussong S.A., Hart M.J., Javors M., Shih Y.Y., Muir E., Solano Fonseca R., Strong R., Richardson A.G., Lechleiter J.D., Fox P.T., Galvan V. 2013. Chronic rapamycin restores brain vascular integrity and function through NO synthase activation and improves memory in symptomatic mice modeling Alzheimer's disease. J. Cereb. Blood Flow Metab. 33:1412-21. doi: 10.1038/jcbfm.2013.82. Epub 2013 Jun 26. [PMID 23801246]

Flynn J.M., O'Leary M.N., Zambataro C.A., Academia E.C., Presley M.P., Garrett B.J., Zykovich A., Mooney S.D., Strong R., Rosen C.J., Kapahi P., Nelson M.D., Kennedy B.K., Melov S. 2013. Late-life rapamycin treatment reverses age-related heart dysfunction. Aging Cell 12:851-62. doi: 10.1111/acel.12109. Epub 2013 Jul 7. [PMID 23734717]

Hasty P., Livi C.B., Dodds S.G., Jones D., Strong R., Javors M., Fischer K.E., Sloane L, Murthy K., Hubbard G., Sun L., Hurez V., Curiel T.J., Sharp Z.D. 2014. eRapa restores a normal life span in a FAP mouse model. Cancer Prev. Res. 7(1):169-78. doi: 10.1158/1940-6207.CAPR-13-0299. Epub 2013 Nov [PMID 24282255]

Liu Y., Diaz V., Fernandez E., Strong R., Ye L., Baur J.A., Lamming D.W., Richardson A., Salmon A.B. 2014. Rapamycin-induced metabolic defects are reversible in both lean and obese mice. Aging 6:742-54. [PMID 25324470]

Rodriguez K.A., Dodds S.G., Strong R., Galvan V., Sharp Z.D., Buffenstein R. 2014. Divergent tissue and sex effects of rapamycin on the proteasome-chaperone network of old mice. Front. Mol. Neuroscience 7:83. doi: 10.3389/fnmol.2014.00083. [PMID 25414638]

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