Research and Funding

Interventions Testing Program (ITP)

Papers from the NIA Interventions Testing Program

Warner, H. R., Ingram, D., Miller, R. A., Nadon, N. L. and Richardson, A. G. (2000) Meeting Report: Program for testing biological interventions to promote healthy aging. Mechanisms of Aging and Development 115:199-208. (PMID 10906513)

Miller, R. A., Harrison, D. E., Astle, C. M., Floyd, R. A., Flurkey, K., Hensley, K. L., Javors, M. A., Leeuwenburgh, C., Nelson, J. F., Ongini, E., Nadon, N. L., Warner, H. R., and Strong, R. (2007) NIA Interventions Testing Program: Study Design and an Interim Report. Aging Cell 6:565-575. PMID PMC2695675. (PMID 17578509)

Nadon, N. L., Strong, R., Miller, R. A., Nelson, J., Javors, M., Sharp, Z. D., Peralba, J. M. and Harrison, D. E. (2008) Design of Aging Intervention Studies: the NIA Interventions Testing Program. AGE 30:187-199. [AGE online - http://dx.doi.org/10.1007/s11357-008-9048-1 ; NIHMSID47726] (PMID 19424842)

Strong, R., Miller, R. A., Astle, C. M., Floyd, R. A., Flurkey K., Hensley, K. L., Javors, M. A., Leeuwenburgh, C., Nelson, J. F., Ongini, E., Nadon, N. L., Warner, H. R., and Harrison, D. E. (2008) Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell 7:641-650. (PMID 18631321)

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., Pahor, M., Javors, M. A., Fernandez, E. and Miller, R. A. (2009) Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 460:392-395. (PMID 19587680)

Miller, R. A., Harrison, D., Astle, C. M., Baur, J. A., deCabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., Pletcher, S., Sharp, Z. D., Sinclair, D., Starnes, J. W., Wilkinson, J. E., Nadon, N. L., Strong, R. (2011) Rapamycin, But Not Resveratrol or Simvastatin, Extends Lifespan of Genetically Heterogeneous Mice. J. Gerontology, Biological Sciences 66A:191-201. (PMID 20974732)

Wilkinson, J. E., Burmeister, L., Brooks, S. V., Carames, B., Friedline, S., Harrison, D., Lotz, M., Nadon, N., Strong, R., Wood, L. K., Woodward, M. A., and Miller, R. A. Rapamycin Slows Aging in Mice. (2012) Aging Cell 11:675-682. (PMID: 22587563)

Strong, R., Miller, R. A., Astle, C. M., Baur, J. A., de Cabo, R., Fernandez, E., Guo, W., Javors, M., Kirkland, J. L., Nelson, J. F., Sinclair, D., Teter, B., Williams, D., Zaveri, N., Nadon, N. L., Harrison, D. E. (2012) Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium chain triglyceride oil on lifespan of genetically heterogeneous mice. J. Gerontology, Biological Sciences 68:6-16. (PMID 22451473)

Wilkinson, J. E., Burmeister, L., Brooks, S. V., Carames, B., Friedline, S., Harrison, D., Lotz, M., Nadon, N., Strong, R., Wood, L. K., Woodward, M. A., and Miller, R. A. Rapamycin Slows Aging in Mice. (2012) Aging Cell 11:675-682. (PMID: 22587563)

Miller, R. A., Harrison, D. E., Astle, C. M., Fernandez, E., Flurkey, K., Han, M., Javors, M. A., Li, X., Nadon, N. L., Nelson, J. F., Pletcher, S., Salmon, A. B., Sharp, Z. D., Van Roekel, S., Winkleman, L., Strong, R. Rapamycin-Mediated Lifespan Increase in Mice is Dose and Sex-Dependent and Metabolically Distinct from Dietary Restriction. (2014) Aging Cell 13:468-477. doi: 10.1111/acel.12194.

Harrison D. E., Strong R., Allison, D. B., Ames, B. N., Astle, C. M., Atamna, H., Fernandez, E., Flurkey, K., Javors, M. A., Nadon, N. L., Nelson, J. F., Simpkins, J. W., Smith, D., Wilkinson, J. E., and Miller, R. A. Acarbose, 17-α-Estradiol, and Nordihydroguaiaretic Acid Extend Mouse Lifespan Preferentially in Males. (2014) Aging Cell, 13:273-282. DOI: 10.1111/acel.12170.

Strong, R., Miller, R. A., Antebi, A., Astle, C. M., Bogue, M., Denzel, M. S., Fernandez, E., Flurkey, K., Hamilton, K. L., Lamming, D. W., Javors, M. A., de Magalhães, J. P., McCord, J. M., Miller, B. F., Müller, M., Nelson, J. F., Ndukum, J., Rainger, G. E., Richardson, A., Sabatini, D. M., Salmon, A. B., Simpkins, J. W., Steegenga, W. T., Nadon, N. L., Harrison, D. E. (2016) Longer lifespan in male mice treated with a weakly-estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer. Aging Cell DOI: 10.1111/acel.12496.