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Compounds In Testing

Each material is given in the diet at the following levels (part per million (PPM) by weight).

Cohort 1: C2004
Compound Concentration in food Age at treatment initiation
Aspirin 20 ppm 4 months
NFP 200 ppm 4 months
NDGA 2,500 ppm 9 months
4-OH-PBN 315 ppm 4 months
Cohort 2: C2005
Compound Concentration in food Age at treatment initiation
CAPE 30 ppm 4 months
CAPE 300 ppm 4 months
Enalapril Maleate 120 ppm 4 months
Rapamycin 14 ppm 20 month
Cohort 3: C2006
Compound Concentration in food Age at treatment initiation
Rapamycin 14 ppm 9 months
Simvastatin 12 ppm 10 months
Simvastatin 120 ppm 10 months
Resveratrol 300 ppm 12 months
Resveratrol 1200 ppm 12 months
Cohort 4: C2007
Compound Concentration in food Age at treatment initiation
Resveratrol 300 ppm 4 months
Oxaloacetic acid 2200 ppm 4 months
Green tea extract 2000 ppm 4 months
Curcumin 2000 ppm 4 months
Medium Chain Triglyceride Oil 60000 ppm 4 months
Cohort 5: C2009
Compound Concentration in food Age at treatment initiation
17α-Estradiol 4.8 ppm 10 months
Methylene Blue 28 ppm 4 months
Acarbose 1000 ppm 4 months
Rapamycin_LoPhase II 4.7 ppm 9 months
Rapamycin_MidPhase II 14 ppm 9 months
Rapamycin_HiPhase II 42 ppm 9 months
Cohort 6: C2010
Compound Concentration in food Age at treatment initiation
Fish Oil 15000 ppm 9 months
Fish Oil 50000 ppm 9 months
NDGA Lo_Phase II 800 ppm 6 months (M only)
NDGA Med_Phase II 2500 ppm 6 months (M only)
NDGA Hi_Phase II 5000 ppm 6 months (M & F)
Cohort 7: C2011
Compound Concentration in food Age at treatment initiation
Bile Acids 5000 ppm 5 months
Metformin 1000 ppm 9 months
Metformin + Rapamycin 1000 ppm M + 14 ppm R 9 months
Protandim® * 600 ppm 10 months
17α-Estradiol 14.4 ppm 10 months

*Protandim® was fed to one group of mice – the Protandim® was increased from 600 ppm to 1200 ppm when the mice reached 17 months of age.

Cohort 8: C2012
Compound Concentration in food Age at treatment initiation
INT-767 FXR/TG5R agonist 180 ppm 10 months
Acarbose 1000 ppm 16 months
HBX (2-(2-hydroxyphenyl)-benzoxazole) 1 ppm 15 months
NDGA cross-section study: Males 2500 ppm 13 months
NDGA cross-section study: Females 5000 ppm 13 months
Cohort 9: C2013
Compound Concentration in food Age at treatment initiation
Ursolic Acid 2000 ppm 10 months
Acarbose Phase II 2500 ppm 8 months
Acarbose Phase II 1000 ppm 8 months
Acarbose Phase II 400 ppm 8 months
Cohort 10: C2014
Compound Concentration in food Age at treatment initiation
Supplemental glycine 80,000 ppm 9 months
TM5441 – inhibitor of PAI-1 60 ppm 11 months
Inulin 600 ppm 11 months
Aspirin 60 ppm 11 months
Aspirin 200 ppm 11 months
Cohort 11: C2015
Compound Concentration in food Age at treatment initiation
17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride (17-DMAG) 30 ppm 6 months
MitoQ 100 ppm 7 months
Minocycline 300 ppm 6 months
β-guanadinopropionic acid (B-GPA) 3300 ppm 6 months
Rapamycin – intermittent Phase II 42 ppm 20 months
Cohort 12: C2016
Compound Concentration in food Age at treatment initiation
MIF098 240 ppm 8 months
Nicotinamide riboside 1000 ppm 8 months
Canagliflozin - SGLT2 inhibitor 180 ppm 7 months
Candesartan Cilexetil 30 ppm 8 months
Geranylgeranyl acetone 600 ppm 9 months
Hydrogen Sulfide - SG1002 240 ppm 19 months
Phase II - 17αEstradiol started in mid-life 14.4 ppm 16 + 20 months
Cohort 13: C2017
Compound Concentration in food Age at treatment initiation
1,3-butanediol 100,000 ppm 6 months
Captopril 180 ppm 5 months
L-Leucine 40,000 ppm 5 months
PB125 100 ppm 5 months
Sulindac 5 ppm 5 months
Syringaresinol 300 ppm 5 months
Phase II - Rapamycin/Acarbose 14.7 ppm/1000 ppm 9 + 16 months
Cohort 14: C2018
Compound Concentration in food Age at treatment initiation
Fisetin on + cycling (3d on/11d off) 600 ppm 20 months
Hydrogen Sulfide - SG1002 midlife 240 ppm 18 months
Cohort 15: C2019
Compound Concentration in food Age at treatment initiation
Astaxanthin 400 ppm 12 months
Dimethyl Fumarate (DMF) 9 + 16 120 ppm 9 months and 16 months
Meclizine 800 ppm 12 months
Mycophenolic Acid (MPA) 6.7 ppm 9 months
4-Phenylbutyrate (PBA) 1000 ppm 9 months
Hydrogen Sulfide - SG1002 240 ppm 6 months
Cohort 16: C2020
Compound Concentration in food Age at treatment initiation
16 alpha-hydroxyestradiol 5 ppm 12 months
2,4-Dinitrophenol 3 ppm 6 months
Hydralazine 30 ppm 6 months
Nebivolol 60 ppm 6 months
Sodium Thiosulfate (STS) 10,000 ppm 6 months
Phase II - Canagliflozin - SGLT2 inhibitor started in mid-life 180 ppm 16 months