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Compounds In Testing

Each material is given in the diet at the following levels (part per million (PPM) by weight).

Cohort 1: C2004
Compound Concentration in food Age at treatment initiation

Aspirin

20 ppm

4 months

NFP

200 ppm

4 months

NDGA

2,500 ppm

9 months

4-OH-PBN

315 ppm

4 months

Cohort 2: C2005
Compound Concentration in food Age at treatment initiation

CAPE

30 ppm

4 months

CAPE

300 ppm

4 months

Enalapril Maleate

120 ppm

4 months

Rapamycin

14 ppm

20 month

Cohort 3: C2006
Compound Concentration in food Age at treatment initiation

Rapamycin

14 ppm

9 months

Simvastatin

12 ppm

10 months

Simvastatin

120 ppm

10 months

Resveratrol

300 ppm

12 months

Resveratrol

1200 ppm

12 months

Cohort 4: C2007
Compound Concentration in food Age at treatment initiation

Resveratrol

300 ppm

4 months

Oxaloacetic acid

2200 ppm

4 months

Green tea extract

2000 ppm

4 months

Curcumin

2000 ppm

4 months

Medium Chain Triglyceride Oil

60000 ppm

4 months

Cohort 5: C2009
Compound Concentration in food Age at treatment initiation

17α-Estradiol

4.8 ppm

10 months

Methylene Blue

28 ppm

4 months

Acarbose

1000 ppm

4 months

Rapamycin_LoPhase II

4.7 ppm

9 months

Rapamycin_MidPhase II

14 ppm

9 months

Rapamycin_HiPhase II

42 ppm

9 months

Cohort 6: C2010
Compound Concentration in food Age at treatment initiation

Fish Oil

15000 ppm

9 months

Fish Oil

50000 ppm

9 months

NDGA Lo_Phase II

800 ppm

6 months (M only)

NDGA Med_Phase II

2500 ppm

6 months (M only)

NDGA Hi_Phase II

5000 ppm

6 months (M & F)

Cohort 7: C2011
Compound Concentration in food Age at treatment initiation

Bile Acids

5000 ppm

5 months

Metformin

1000 ppm

9 months

Metformin + Rapamycin

1000 ppm M + 14 ppm R

9 months

Protandim® *

600 ppm

10 months

17α-Estradiol

14.4 ppm

10 months

*Protandim® was fed to one group of mice – the Protandim® was increased from 600 ppm to 1200 ppm when the mice reached 17 months of age.

Cohort 8: C2012
Compound Concentration in food Age at treatment initiation

INT-767 FXR/TG5R agonist

180 ppm

10 months

Acarbose

1000 ppm

16 months

HBX (2-(2-hydroxyphenyl)-benzoxazole)

1 ppm

15 months

NDGA cross-section study: Males

2500 ppm

13 months

NDGA cross-section study: Females

5000 ppm

13 months

Cohort 9: C2013
Compound Concentration in food Age at treatment initiation

Ursolic Acid

2000 ppm

10 months

Acarbose Phase II

2500 ppm

8 months

Acarbose Phase II

1000 ppm

8 months

Acarbose Phase II

400 ppm

8 months

Cohort 10: C2014
Compound Concentration in food Age at treatment initiation

Supplemental glycine

80,000 ppm

9 months

TM5441 – inhibitor of PAI-1

60 ppm

11 months

Inulin

600 ppm

11 months

Aspirin

60 ppm

11 months

Aspirin

200 ppm

11 months

Cohort 11: C2015
Compound Concentration in food Age at treatment initiation

17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride (17-DMAG)

30 ppm

6 months

MitoQ

100 ppm

7 months

Minocycline

300 ppm

6 months

β-guanadinopropionic acid (B-GPA)

3300 ppm

6 months

Rapamycin – intermittent Phase II

42 ppm

20 months

Cohort 12: C2016

Compound

Concentration in food

Age at treatment initiation

MIF098

240 ppm

8 months

Nicotinamide riboside

1000 ppm

8 months

Canagliflozin - SGLT2 inhibitor

180 ppm

7 months

Candesartan Cilexetil

30 ppm

8 months

Geranylgeranyl acetone

600 ppm

9 months

Hydrogen Sulfide - SG1002

240 ppm

19 months

Phase II - 17αEstradiol started in mid-life

14.4 ppm

16 + 20 months

Cohort 13: C2017

Compound

Concentration in food

Age at treatment initiation

1,3-butanediol

100,000 ppm

6 months

Captopril

180 ppm

5 months

L-Leucine

40,000 ppm

5 months

PB125

100 ppm

5 months

Sulindac

5 ppm

5 months

Syringaresinol

300 ppm

5 months

Phase II - Rapamycin/Acarbose

14.7 ppm/1000 ppm

9 + 16 months

Cohort 14: C2018

Compound

Concentration in food

Age at treatment initiation

Fisetin on + cycling (3d on/11d off)

600 ppm

20 months

Hydrogen Sulfide - SG1002 midlife

240 ppm

18 months

Cohort 15: C2019

Compound

Concentration in food

Age at treatment initiation

Astaxanthin

4000 ppm

12 months

Dimethyl Fumarate (DMF) 9 + 16

120 ppm

9 months and 16 months

Meclizine

800 ppm

12 months

Mycophenolic Acid (MPA)

6.7 ppm

9 months

4-Phenylbutyrate (PBA)

1000 ppm

9 months

Hydrogen Sulfide - SG1002

240 ppm

6 months

Cohort 16: C2020

Compound

Concentration in food

Age at treatment initiation

16 alpha-hydroxyestradiol

5 ppm

12 months

2,4-Dinitrophenol

3 ppm

6 months

Hydralazine

30 ppm

6 months

Nebivolol

60 ppm

6 months

Sodium Thiosulfate (STS)

10,000 ppm

6 months

Phase II - Canagliflozin - SGLT2 inhibitor started in mid-life

180 ppm

16 months