Compounds In Testing
Each material is given in the diet at the following levels (part per million (PPM) by weight).
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
Aspirin |
20 ppm |
4 months |
|
NFP |
200 ppm |
4 months |
|
NDGA |
2,500 ppm |
9 months |
|
4-OH-PBN |
315 ppm |
4 months |
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
CAPE |
30 ppm |
4 months |
|
CAPE |
300 ppm |
4 months |
|
Enalapril Maleate |
120 ppm |
4 months |
|
Rapamycin |
14 ppm |
20 month |
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
Rapamycin |
14 ppm |
9 months |
|
Simvastatin |
12 ppm |
10 months |
|
Simvastatin |
120 ppm |
10 months |
|
Resveratrol |
300 ppm |
12 months |
|
Resveratrol |
1200 ppm |
12 months |
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
Resveratrol |
300 ppm |
4 months |
|
Oxaloacetic acid |
2200 ppm |
4 months |
|
Green tea extract |
2000 ppm |
4 months |
|
Curcumin |
2000 ppm |
4 months |
|
Medium Chain Triglyceride Oil |
60000 ppm |
4 months |
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
17α-Estradiol |
4.8 ppm |
10 months |
|
Methylene Blue |
28 ppm |
4 months |
|
Acarbose |
1000 ppm |
4 months |
|
Rapamycin_LoPhase II |
4.7 ppm |
9 months |
|
Rapamycin_MidPhase II |
14 ppm |
9 months |
|
Rapamycin_HiPhase II |
42 ppm |
9 months |
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
Fish Oil |
15000 ppm |
9 months |
|
Fish Oil |
50000 ppm |
9 months |
|
NDGA Lo_Phase II |
800 ppm |
6 months (M only) |
|
NDGA Med_Phase II |
2500 ppm |
6 months (M only) |
|
NDGA Hi_Phase II |
5000 ppm |
6 months (M & F) |
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
Bile Acids |
5000 ppm |
5 months |
|
Metformin |
1000 ppm |
9 months |
|
Metformin + Rapamycin |
1000 ppm M + 14 ppm R |
9 months |
|
Protandim® * |
600 ppm |
10 months |
|
17α-Estradiol |
14.4 ppm |
10 months |
*Protandim® was fed to one group of mice – the Protandim® was increased from 600 ppm to 1200 ppm when the mice reached 17 months of age.
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
INT-767 FXR/TG5R agonist |
180 ppm |
10 months |
|
Acarbose |
1000 ppm |
16 months |
|
HBX (2-(2-hydroxyphenyl)-benzoxazole) |
1 ppm |
15 months |
|
NDGA cross-section study: Males |
2500 ppm |
13 months |
|
NDGA cross-section study: Females |
5000 ppm |
13 months |
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
Ursolic Acid |
2000 ppm |
10 months |
|
Acarbose Phase II |
2500 ppm |
8 months |
|
Acarbose Phase II |
1000 ppm |
8 months |
|
Acarbose Phase II |
400 ppm |
8 months |
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
Supplemental glycine |
80,000 ppm |
9 months |
|
TM5441 – inhibitor of PAI-1 |
60 ppm |
11 months |
|
Inulin |
600 ppm |
11 months |
|
Aspirin |
60 ppm |
11 months |
|
Aspirin |
200 ppm |
11 months |
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride (17-DMAG) |
30 ppm |
6 months |
|
MitoQ |
100 ppm |
7 months |
|
Minocycline |
300 ppm |
6 months |
|
β-guanadinopropionic acid (B-GPA) |
3300 ppm |
6 months |
|
Rapamycin – intermittent Phase II |
42 ppm |
20 months |
|
Compound |
Concentration in food |
Age at treatment initiation |
|---|---|---|
|
MIF098 |
240 ppm |
8 months |
|
Nicotinamide riboside |
1000 ppm |
8 months |
|
Canagliflozin - SGLT2 inhibitor |
180 ppm |
7 months |
|
Candesartan Cilexetil |
30 ppm |
8 months |
|
Geranylgeranyl acetone |
600 ppm |
9 months |
|
Hydrogen Sulfide - SG1002 |
240 ppm |
19 months |
|
Phase II - 17αEstradiol started in mid-life |
14.4 ppm |
16 + 20 months |
|
Compound |
Concentration in food |
Age at treatment initiation |
|---|---|---|
|
1,3-butanediol |
100,000 ppm |
6 months |
|
Captopril |
180 ppm |
5 months |
|
L-Leucine |
40,000 ppm |
5 months |
|
PB125 |
100 ppm |
5 months |
|
Sulindac |
5 ppm |
5 months |
|
Syringaresinol |
300 ppm |
5 months |
|
Phase II - Rapamycin/Acarbose |
14.7 ppm/1000 ppm |
9 + 16 months |
|
Compound |
Concentration in food |
Age at treatment initiation |
|---|---|---|
|
Fisetin on + cycling (3d on/11d off) |
600 ppm |
20 months |
|
Hydrogen Sulfide - SG1002 midlife |
240 ppm |
18 months |
|
Compound |
Concentration in food |
Age at treatment initiation |
|---|---|---|
|
Astaxanthin |
4000 ppm |
12 months |
|
Dimethyl Fumarate (DMF) 9 + 16 |
120 ppm |
9 months and 16 months |
|
Meclizine |
800 ppm |
12 months |
|
Mycophenolic Acid (MPA) |
6.7 ppm |
9 months |
|
4-Phenylbutyrate (PBA) |
1000 ppm |
9 months |
|
Hydrogen Sulfide - SG1002 |
240 ppm |
6 months |
|
Compound |
Concentration in food |
Age at treatment initiation |
|---|---|---|
|
16 alpha-hydroxyestradiol |
5 ppm |
12 months |
|
2,4-Dinitrophenol |
3 ppm |
6 months |
|
Hydralazine |
30 ppm |
6 months |
|
Nebivolol |
60 ppm |
6 months |
|
Sodium Thiosulfate (STS) |
10,000 ppm |
6 months |
|
Phase II - Canagliflozin - SGLT2 inhibitor started in mid-life |
180 ppm |
16 months |
