Compounds In Testing
Each material is given in the diet at the following levels (part per million (PPM) by weight).
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
Aspirin
|
20 ppm
|
4 months
|
|
NFP
|
200 ppm
|
4 months
|
|
NDGA
|
2,500 ppm
|
9 months
|
|
4-OH-PBN
|
315 ppm
|
4 months
|
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
CAPE
|
30 ppm
|
4 months
|
|
CAPE
|
300 ppm
|
4 months
|
|
Enalapril Maleate
|
120 ppm
|
4 months
|
|
Rapamycin
|
14 ppm
|
20 month
|
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
Rapamycin
|
14 ppm
|
9 months
|
|
Simvastatin
|
12 ppm
|
10 months
|
|
Simvastatin
|
120 ppm
|
10 months
|
|
Resveratrol
|
300 ppm
|
12 months
|
|
Resveratrol
|
1200 ppm
|
12 months
|
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
Resveratrol
|
300 ppm
|
4 months
|
|
Oxaloacetic acid
|
2200 ppm
|
4 months
|
|
Green tea extract
|
2000 ppm
|
4 months
|
|
Curcumin
|
2000 ppm
|
4 months
|
|
Medium Chain Triglyceride Oil
|
60000 ppm
|
4 months
|
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
17α-Estradiol
|
4.8 ppm
|
10 months
|
|
Methylene Blue
|
28 ppm
|
4 months
|
|
Acarbose
|
1000 ppm
|
4 months
|
|
Rapamycin_LoPhase II
|
4.7 ppm
|
9 months
|
|
Rapamycin_MidPhase II
|
14 ppm
|
9 months
|
|
Rapamycin_HiPhase II
|
42 ppm
|
9 months
|
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
Fish Oil
|
15000 ppm
|
9 months
|
|
Fish Oil
|
50000 ppm
|
9 months
|
|
NDGA Lo_Phase II
|
800 ppm
|
6 months (M only)
|
|
NDGA Med_Phase II
|
2500 ppm
|
6 months (M only)
|
|
NDGA Hi_Phase II
|
5000 ppm
|
6 months (M & F)
|
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
Bile Acids
|
5000 ppm
|
5 months
|
|
Metformin
|
1000 ppm
|
9 months
|
|
Metformin + Rapamycin
|
1000 ppm M + 14 ppm R
|
9 months
|
|
Protandim® *
|
600 ppm
|
10 months
|
|
17α-Estradiol
|
14.4 ppm
|
10 months
|
*Protandim® was fed to one group of mice – the Protandim® was increased from 600 ppm to 1200 ppm when the mice reached 17 months of age.
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
INT-767 FXR/TG5R agonist
|
180 ppm
|
10 months
|
|
Acarbose
|
1000 ppm
|
16 months
|
|
HBX (2-(2-hydroxyphenyl)-benzoxazole)
|
1 ppm
|
15 months
|
|
NDGA cross-section study: Males
|
2500 ppm
|
13 months
|
|
NDGA cross-section study: Females
|
5000 ppm
|
13 months
|
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
Ursolic Acid
|
2000 ppm
|
10 months
|
|
Acarbose Phase II
|
2500 ppm
|
8 months
|
|
Acarbose Phase II
|
1000 ppm
|
8 months
|
|
Acarbose Phase II
|
400 ppm
|
8 months
|
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
Supplemental glycine
|
80,000 ppm
|
9 months
|
|
TM5441 – inhibitor of PAI-1
|
60 ppm
|
11 months
|
|
Inulin
|
600 ppm
|
11 months
|
|
Aspirin
|
60 ppm
|
11 months
|
|
Aspirin
|
200 ppm
|
11 months
|
| Compound | Concentration in food | Age at treatment initiation |
|---|---|---|
|
17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride (17-DMAG)
|
30 ppm
|
6 months
|
|
MitoQ
|
100 ppm
|
7 months
|
|
Minocycline
|
300 ppm
|
6 months
|
|
β-guanadinopropionic acid (B-GPA)
|
3300 ppm
|
6 months
|
|
Rapamycin – intermittent Phase II
|
42 ppm
|
20 months
|
|
Compound
|
Concentration in food
|
Age at treatment initiation
|
|---|---|---|
|
MIF098
|
240 ppm
|
8 months
|
|
Nicotinamide riboside
|
1000 ppm
|
8 months
|
|
Canagliflozin - SGLT2 inhibitor
|
180 ppm
|
7 months
|
|
Candesartan Cilexetil
|
30 ppm
|
8 months
|
|
Geranylgeranyl acetone
|
600 ppm
|
9 months
|
|
Hydrogen Sulfide - SG1002
|
240 ppm
|
19 months
|
|
Phase II - 17αEstradiol started in mid-life
|
14.4 ppm
|
16 + 20 months
|
|
Compound
|
Concentration in food
|
Age at treatment initiation
|
|---|---|---|
|
1,3-butanediol
|
100,000 ppm
|
6 months
|
|
Captopril
|
180 ppm
|
5 months
|
|
L-Leucine
|
40,000 ppm
|
5 months
|
|
PB125
|
100 ppm
|
5 months
|
|
Sulindac
|
5 ppm
|
5 months
|
|
Syringaresinol
|
300 ppm
|
5 months
|
|
Phase II - Rapamycin/Acarbose
|
14.7 ppm/1000 ppm
|
9 + 16 months
|
|
Compound
|
Concentration in food
|
Age at treatment initiation
|
|---|---|---|
|
Fisetin on + cycling (3d on/11d off)
|
600 ppm
|
20 months
|
|
Hydrogen Sulfide - SG1002 midlife
|
240 ppm
|
18 months
|
|
Compound
|
Concentration in food
|
Age at treatment initiation
|
|---|---|---|
|
Astaxanthin
|
400 ppm
|
12 months
|
|
Dimethyl Fumarate (DMF) 9 + 16
|
120 ppm
|
9 months and 16 months
|
|
Meclizine
|
800 ppm
|
12 months
|
|
Mycophenolic Acid (MPA)
|
6.7 ppm
|
9 months
|
|
4-Phenylbutyrate (PBA)
|
1000 ppm
|
9 months
|
|
Hydrogen Sulfide - SG1002
|
240 ppm
|
6 months
|