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Common Fund Programs with DAB Participation

DAB encourages investigators to make use of resources generated through NIH Common Fund programs by submitting applications for new or competing revisions to their biology of aging research grants. A full list of NIH Common Fund programs is available here, and DAB program staff are engaged in the programs listed below.


4D Nucleome (4DN): The goal of this Common Fund program is to study the three-dimensional organization of the nucleus in space and time (the 4th dimension).

  • DAB Staff Contact: Max Guo, Ph.D.

Cellular Senescence Network (SenNet): This Common Fund program aims to comprehensively identify and characterize the differences in senescent cells across the body, across various states of human health, and across the lifespan.

Extracellular RNA Communication (ERC): The ERC program is exploring the biology of extracellular RNA (exRNA), which is known to play a role in cell-to-cell communication.

  • DAB Staff Contact: Max Guo, Ph.D.

The Human BioMolecular Atlas Program (HuBMAP): The goal of the HuBMAP is to develop an open and global platform to map healthy cells in the human body.

Knockout Mouse Phenotyping Program (KOMP2): This program aims to ablate and characterize all protein-coding genes in the C57BL/6 mouse genome.

Molecular Transducers of Physical Activity in Humans (MoTrPAC): This Common Fund program aims to uncover, at the molecular level, how exercise improves and maintains the health of the body’s tissues and organs.

Metabolomics: The goal of the Metabolomics program is to improve methods for studying the chemical reactions that occur in organisms, cells, or tissues, and make those methods more accessible to researchers, allowing for more personalized diagnosis of disease and treatment methods.

Somatic Mosaicism Across Human Tissues (SMaHT): This Common Fund program aims to transform our understanding of how somatic mosaicism in human cells influences biology and disease.

  • DAB Staff Contact: Max Guo, Ph.D.

High Risk High Reward Research Programs support scientists pursuing highly innovative research with the potential for broad impact in biomedical, behavioral, or social sciences within the NIH mission. Preliminary data are not required.

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