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Agenda: Tissue-Resident Immune Cells

A Concepts in Geroscience Postdoctoral Fellows Symposium

Lister Hill Auditorium (NIH Main Campus)
Bethesda, MD
June 4-6, 2019

TUESDAY, June 4, 2019

9:00 AM Introduction: Ronald A. Kohanski, Ph.D.

Deputy Director, Division of Aging Biology, National Institute on Aging

9:05 AM Plenary Lecture: GR Scott Budinger, M.D.

Ernest S. Bazley Professor of Airway Diseases and Chief of the Division of Pulmonary and Critical Care Medicine at the Feinberg School of Medicine of Northwestern University

Understanding Aging through the Prism of Alveolar Macrophages

10:05 – 10:20 Break

10:20 AM Kimberly Jasmer-McDonald, Ph.D., University of Missouri-Columbia (NIDCR)

P2Y2 Receptor Antagonism Inhibits B-lymphocyte Function and Inflammation in the NOD.H-2h4,IFNγ-/-,CD28-/- Mouse Model of Sjögren’s Syndrome

10:45 AM Jaeyoung Lee, Ph.D., University of California – Los Angeles (NIDCR)

Histone Lys Demethylase KDM3C Demonstrates Anti-inflammatory Effects by Suppressing NF-kB Signaling and Osteoclastogenesis

11:10 AM Matthew J. McConnell, Ph.D., University of Alabama at Birmingham (NIDCR)

Core-binding Factor Subunit Beta Attenuates Inflammation, Inhibits Bone Erosion, and Enhances Tissue Regeneration in a Mouse Model of Periodontal Disease

11:35 AM William Foulsham, M.D., Harvard University (NEI)

An Amplified Memory Th17 Pool Predisposes Aged Mice to Severe Exacerbations of Dry Eye Disease

12:00 PM Matthew Pennington, Ph.D., Harvard University (NEI)

Defining Adenovirus Induced Inflammation on the Ocular Surface

12:25 – 1:25 LUNCH with PROGRAM OFFICERS

1:25 PM Maria Amezcua Vesely, Ph.D., Yale University School of Medicine (NCI)

Effectors TH17 Cells Give Rise to Long-lived TRM Cells that Are Essential for An Immediate Response Against Bacterial Infection

1:50 PM Chun (Jim) Chou, Ph.D., Memorial Sloan Kettering Cancer Center (NCI)

Plotting Against Cancer: Which Killer to Hire?

2:15 PM Kavya Rakhra, Ph.D., Koch Institute for Integrative Cancer (NCI)

Potent Generation of Tissue-resident T-cells by A Mucosa-penetrating Peptide Vaccine

2:40 PM Pamela Rosato, Ph.D., University of Minnesota Medical School (NCI)

Repurposing Antiviral Tissue-resident Memory T Cells for Tumor Immunotherapy

3:05 – 3:20 Break

3:20 PM Stefan Uderhardt, M.D., National Institute of Allergy and Infectious Diseases (NIAID)

Effectors Versus Protectors: How Anti-inflammatory Tissue Macrophages Maintain Tissue Homeostasis

3:45 PM Henrique Borges da Silva, Ph.D., University of Minnesota (NIAID)

Extracellular ATP Sensing via P2RX7 Promotes CD8+ T Cell Tissue-resident Memory Generation Through Enhancing TGF-beta Sensitivity

4:10 PM Kyla Omilusik, Ph.D., University of California, San Diego (NIAID)

Heterogeneity Within the Resident Memory CD8+ T Cell Population

4:35 PM Peter Szabo, Ph.D., Columbia University (NIAID)

A Single-cell Reference Map for Human Blood and Tissue T Cell Activation Reveals Functional States in Health and Disease


WEDNESDAY, June 5, 2019

9:00 AM Leslie Frieden, Ph.D., National Institute of Dental and Craniofacial Research

Program Officers’ Presentation on NIH Processes and Funding

10:00 AM Address by Francis S. Collins, M.D., Ph.D., Director, National Institutes of Health

(Introduced by Dr. Jovier Evans, Chief of the Geriatrics and Aging Processes Research Branch at NIMH)

10:10 – 10:30 Break

10:30 AM W. Reid Bolus, Ph.D., University of California – San Francisco (NIDDK)

Probing the Role of Adipogenic Progenitors in Aging and Obesity

10:55 AM Kristine-Ann Buela, Ph.D., Case Western Reserve University (NIDDK)

NOD2 is Critical for Host Defense Against Candida Tropicalis and for Recovery Against Mycobiome-driven Intestinal Disease

11:20 AM Daniel B. Harmon, Ph.D., University of Pittsburgh (NIDDK)

Liver Immune Cells and Metabolic Regulation

11:45 AM Shankar S. Iyer, Ph.D., Brigham and Women's Hospital (NIDDK)

Characterizing Early Life Developmental Cues that Influence the Expansion of Invariant Natural Killer T Cells in Peripheral Organs in Later Life

12:10 – 1:10 LUNCH with PROGRAM OFFICERS

1:10 PM Jennifer Walker, Ph.D., Washington University (NIDDK)

Urinary Catheter-induced Inflammation Sets the Stage for Biofilm Formation and Urinary Tract Infection

1:35 PM Ellen E. Gillis, Ph.D., Augusta University (NHLBI)

Sex Differences in Renal Treg Recruitment in Spontaneously Hypertensive Rats

2:00 PM Anukul T. Shenoy, M.S., Ph.D., Boston University School of Medicine (NHLBI)

Lung- resident CD4+ Memory T Cell and Epithelial Crosstalk During Heterotypic Immunity

2:25 PM Erin B. Taylor, Ph.D., University of Mississippi Medical Center (NHLBI)

The Role of Autoantibodies in the Development of Hypertension and Vascular Dysfunction in Autoimmunity

2:50 – 3:05 Break

3:05 PM Justine M. Abais-Battad, Ph.D., Medical College of Wisconsin (NHLBI)

Transcriptomic Analysis in Renal T Lymphocytes Exposes Sodium-Independent Dietary Differences in Dahl Salt-Sensitive Rats

3:30 PM Daniel B. McKim, Ph.D., University of Illinois Urbana-Champaign (NIMH)

Extramedullary Monopoiesis Underlies Stress-sensitization and Recurring Anxiety

3:55 PM Adriana Ramos, Ph.D., Johns Hopkins University School of Medicine (NIMH)

The Nuclear GAPDH Cascade Mediates Microglial Regulation of Cognitive Flexibility

4:20 PM Julia Scordo, Ph.D., Texas Biomedical Research Institute (NIA)

Heterogeneity in the Human Lung Mucosa Dictates Mycobacterium Tuberculosis Infection Outcome in Alveolar Epithelial Cells


THURSDAY, June 6, 2019

9:00 AM Lindsay Hohsfield, Ph.D., University of California, Irvine (NINDS)

Exploiting Colony-stimulating Factor 1 Receptor Inhibition to Manipulate Myeloid Cell Population Dynamics in the Adult Brain

9:25 AM Monica Santisteban, Ph.D., Weill Cornell Medical College (NINDS)

The Role of Perivascular Macrophages in Neurovascular Dysfunction

9:50 AM Emily L. Goldberg, Ph.D., Yale University School of Medicine (NIA)

Harnessing Immune-metabolic Interactions to Regulate Tissue Homeostasis

10:15 AM Christina Camell, Ph.D., Yale University School of Medicine (NIA)

Tissue Resident Macrophages Drive Adipose Dysfunction during Aging

10:40 AM Program Officers: Wrap-up

11:00 AM ADJOURN with Box Lunch

NIH Program Staff for this Symposium

Howcroft, Kevin (NCI)

Jhappan, Chamelli (NCI)

McKie, George (NEI)

Oh, Young (NHLBI)

Fuldner, Rebecca (NIA)

Kohanski, Ron (NIA)

Prabhudas, Mercy (NIAID)

Vedamony, Merriline (NIAID)

Chander, Preethi (NIDCR)

Frieden, Leslie (NIDCR)

Abraham, Kristin (NIDDK)

Evans, Jovier (NIMH)

Corriveau, Rod (NINDS)

Administrative Organization for this Symposium

Chau, Nhi (NIA)

Konde, Nimi (NIA)