Division of Aging Biology
The Division of Aging Biology promotes and supports research and training on the molecular, cellular, genetic, and physiological mechanisms underlying normal aging and age-related pathologies. The objective of DAB-funded research is to elucidate the basic biochemical, genetic, and physiological mechanisms underlying the process of aging and age-related changes in humans and in animal models of human aging. This includes investigations of the gradual or programmed alterations of structure and function that characterize normal aging and investigations of how these adverse changes become risk factors for, or accompany, age-related conditions and disease states.
Featured Funding Opportunities
Geroscience Approaches to Alzheimer's Disease: Acceleration of Phenotypes in Asymptomatic Models of AD
Test whether interventions that accelerate aging can induce AD-like phenotypes in animal models that do not show significant AD phenotypes. Applications due April 17, 2018. See NOT-AG-18-001. Submit under PAR-18-596. Email Felipe Sierra.
Geroscience Approaches to Alzheimer's Disease: Delay of Phenotypes in Current Models of AD
Test whether extended lifespan or healthspan can impact the time of appearance or penetrance of AD over the lifespan of laboratory animal models of AD. See NOT-AG-18-001. Submit under PAR-18-596. Email Felipe Sierra.
Immunity in the Elderly (R01, Clinical Trial Optional)
This FOA, a collaborative initiative between NIA, NIAID and NIDCR, encourages studies to expand our understanding of age-related changes occurring in immune function that influence responses to pathogen and/or vaccines in elderly individuals, including the effects of chronic inflammation on those responses. Human studies are required, and inclusion of relevant animal studies are permitted for mechanistic understanding.