The Division of Aging Biology promotes and supports research and training on the molecular, cellular, genetic, and physiological mechanisms underlying normal aging and age-related pathologies. The objective of DAB-funded research is to elucidate the basic biochemical, genetic, and physiological mechanisms underlying the process of aging and age-related changes in humans and in animal models of human aging. This includes investigations of the gradual or programmed alterations of structure and function that characterize normal aging and investigations of how these adverse changes become risk factors for, or accompany, age-related conditions and disease states.