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Scientific Resources

Increasing the usability of big data for Alzheimer’s research

Suzana PETANCESKA, Health Scientist Administrator, Division of Neuroscience (DN)

On October 11, 2016, the first manuscript describing a treasure trove of genomic data contributed by members of the Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) Target Discovery and Preclinical Validation Consortium was published in Nature Scientific Data. The publication of the datasets and their description are part of an NIH-wide effort to bring together big data and experts from diverse disciplines to better understand dementia, as well as other chronic conditions.

A crash course for clinical specialists

Susan ZIEMAN, Medical Officer, Division of Geriatrics and Clinical Gerontology (DGCG)

On September 21–23, 2016 almost 100 physicians and researchers attended the second biennial GEMSSTAR Scholars Conference, “Models and Studies of Aging,” here in Bethesda. The meeting was sponsored by a U13 conference grant from the NIA to the American Geriatrics Society (AGS), with additional support from the John A. Hartford Foundation.

The NIA Clinical Trial Toolbox: A resource for quality studies

Sergei ROMASHKAN, , Division of Geriatrics and Clinical Gerontology (DGCG)

So you think you want to conduct a clinical trial? Of course, it’s a very complex undertaking. Each stage requires you to comply with regulatory and research standards. And from scientific protocols to procedural manuals, several key documents drive both trial operations and protocol compliance. I’m pleased to let you know that NIA has come up with one way to help you streamline study start-up and adhere to standards.

Meet the director of the Division of Neuroscience

Eliezer MASLIAH, Director, Division of Neuroscience (DN)

On July 18, NIA Director Dr. Richard Hodes announced that Dr. Eliezer Masliah had been appointed director of the Division of Neuroscience. Dr. Masliah was previously at the University of California, San Diego and a member of the National Advisory Council on Aging. “Inside NIA” sat down with Dr. Masliah to talk about his research plans for the division.


Go4Life – Maintaining good health and function

Chhanda DUTTA, Chief, Clinical Gerontology Branch, Division of Geriatrics and Clinical Gerontology (DGCG)

This month, NIA is celebrating our second annual Go4Life Month. As part of that celebration, we’re reaching out to our Go4Life® partners and the research community to help us find ways to encourage older people to exercise and lead healthy, active lives. This year’s theme is “Fit4Function.” So what is Fit4Function all about, anyway?

Reproducibility: Another bureaucratic speed bump?

John WILLIAMS, Health Scientist Administrator, Division of Aging Biology (DAB)

So you thought your science was already rigorous and reproducible…

Last fall, NIH released new guidelines for implementing rigor and transparency in research project grants. Applications for research grants and mentored career development awards submitted in 2016 must include information on scientific rigor and reproducibility. What’s going on?

Connect with NIA at AGS!

Marie BERNARD, Deputy Director, Office of the Director (OD)

California, here we come! No, we’re not participating in a gold rush, we’re going to the annual meeting of the American Geriatrics Society (AGS) next week in Long Beach. We’re looking forward to seeing old friends and making new ones. We also hope that you’ll take the opportunity to connect with NIA staff at the meeting, during scientific sessions and at the Exhibit Hall.

The Clinical Trials Advisory Panel: A good start for a clinical trial

Sergei ROMASHKAN, , Division of Geriatrics and Clinical Gerontology (DGCG)

Large-scale clinical trials are expensive. They require a lot of time and money on the part of the investigators. So does preparing an NIH application for a clinical trial. One way you can save time and money at the beginning of the process is to submit a concept proposal for your trial to NIA’s Clinical Trials Advisory Panel (CTAP).

Data sharing: The name of the game in Alzheimer’s research

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Thousands of gene candidates in the human genome have the potential to play a role in the onset and progression of Alzheimer’s disease. But you are just one scientist. How can you even start such an enormous task? This quest—one scientist analyzing thousands of gene candidates—can seem overwhelming. I want to share with you two great NIA-funded resources that collect and store biological specimens and data—and are available to you and the wider research community.