Research and Funding

Dr. Etienne Sibille September 4 at the GeroScience Interest Group (GSIG) summer seminar

August 15, 2014

Subject: Dr. Etienne Sibille September 4 at the GeroScience Interest Group (GSIG) summer seminar
When: Thursday, September 4, 2014, 12:00 PM – 1:00 PM
Where: Lipsett Amphitheater, Building 10, NIH
Title: "Age-by-Disease interactions in the Human Brain: Evidence & Model"

NOTE: This seminar is open to the public, but please allow time to clear security.

Import this event into Outlook or other calendars as an ICS file (Outlook, 9K).

The Trans-NIH GeroScience Interest Group (GSIG) cordially invites you to its summer seminar, featuring Dr. Etienne Sibille. Dr. Sibille is the Campbell Family chair in Clinical Neuroscince, in the Campbell Family Mental Health Research Institute , Centre for Addiction and Mental Health (CAMH), in the Department of Psychiatry at the University of Toronto. Dr. Sibille’s research goals have consistently focused on translational research aimed at identifying the cellular and molecular bases of depression, and specifically of the mood and affect dysregulation components of the illness. Studies in his laboratory encompass parallel investigations in postmortem brains of depressed and control subjects, and in genetic and environmental rodent models, with the aims of characterizing the primary pathology of depression and assessing causal links between identified molecular changes or candidate neurotransmitter systems and mood regulation. Current projects include translating human postmortem findings on the role of the GABA microcircuitry in mood regulation, and specifically of reduced somatostatin-positive dendritic targeting interneuron function. In addition, they have demonstrated that biological pathways affected during aging of the human brain largely overlap with neuropsychiatric and other neurological disease pathways and may in fact promote diseases, together providing a compelling rationale for investigating aging and diseases simultaneously. These latter hypotheses are now being tested in parallel in the human postmortem brain and in large epidemiological studies of subjects at the “vigor-to-frailty transition.”

The GeroScience Interest Group (GSIG) was formed to enhance opportunities for discussion of the intersection between the biology of aging and the biology of disease and conditions that are of interest across ICs. It is focused on basic biology, but with a longer view towards translation. If you are interested in learning more, please visit the GSIG web site (

The seminar will be videocast at and archived in the GSIG web site.

Sign Language Interpreters will be provided. Individuals with disabilities who need reasonable accommodation to participate in this event should contact Dr. Jovier Evans at or at 301/443-6328 or Dr. Ron Kohanski at or at 301/496-6402.

Please send your questions related to the seminar to or

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