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Accelerating Medicines Partnership - Alzheimer's Disease (AMP-AD)

Lab equipment

Accelerating Alzheimer's Research and Drug Development

Learn more about the AMP-AD program, a precompetitive partnership among government, industry, and nonprofit organizations that focuses on discovering novel, clinically relevant therapeutic targets and on developing biomarkers to help validate existing therapeutic targets.

What is AMP?

The Accelerating Medicines Partnership (AMP) is a bold venture among the National Institutes of Health (NIH), 12 biopharmaceutical and life sciences companies, and several nonprofit organizations to transform the current model for developing new diagnostics and treatments by jointly identifying and validating promising biological targets of disease. This precompetitive collaboration harnesses collective capabilities, scale, and resources across multiple sectors to improve therapeutic development efforts for complex, heterogeneous diseases.

AMP's goal is to understand such diseases more fully through research to identify and validate novel, clinically relevant therapeutic targets. As a result, it is expected to accelerate the process of bringing new medicines to patients.

AMP is an umbrella partnership with initial programs in three disease areas:

In January 2018, an additional AMP project on Parkinson's disease was launched with 9 partners.

This multi-sector partnership is managed by the Foundation for the NIH (FNIH). NIH and industry partners are sharing expertise and resources—over $300 million of combined funding support and in-kind contributions over 5 years—in an integrated governance structure that enables the best-informed scientific contributions from all participants. A critical component of the partnership is making AMP data publicly accessible for use by the broad research community.

More information about AMP (NIH).

What is AMP-AD?

Dementia, of which Alzheimer's disease is the most common form, is estimated to affect 36 million people worldwide. This number is expected to rise to 115 million by 2050 unless an effective therapeutic is developed. The financial toll of dementia is already staggering: In the U.S. alone, the costs of caring for people over age 70 with dementia were estimated to be as high as $215 billion in 2010.

Despite a substantial R&D investment for Alzheimer's disease and advances in our understanding of the disease pathogenesis, safe and effective treatments are still lacking. This reflects the need for a change in how the academic, biopharmaceutical, and government sectors that participate in Alzheimer’s disease research and therapy development generate, share, and use knowledge to propel development of critically needed therapies. It is becoming apparent that real progress in developing effective therapies will require transforming the Alzheimer’s research and drug development process into one that is participatory, collaborative, well-integrated, and iterative.

The AMP-AD program is a precompetitive partnership among government, industry, and nonprofit organizations that focuses on discovering novel, clinically relevant therapeutic targets and on developing biomarkers to help validate existing therapeutic targets. This multisector partnership is managed by the Foundation for the NIH. The combined funding support for this 5-year endeavor is $185.2 million dollars.

AMP-AD budget: 5 years

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*Does not include in-kind contributions of $40M

AMP-AD projects

  • Biomarkers Project—This project explores the utility of tau imaging and novel fluid biomarkers for tracking responsiveness to treatment and/or disease progression.
  • Target Discovery and Preclinical Validation Project—This project seeks to shorten the time between discovery of potential drug targets to development of new drugs for Alzheimer’s treatment and prevention. The project integrates analysis of large-scale molecular data from human brain samples with network modeling approaches and experimental validation, and enables rapid, broad sharing of data and analytical tools.

Partners and Governance

Partner organizations




The FNIH, managing partner for AMP-AD, is actively recruiting new industry and nonprofit partners. Inquiries about how your organization can join the partnership should be submitted to David Wholley, Director for Research Partnerships, at


AMP is a multi-sector partnership managed by the FNIH. NIH and industry partners share expertise and resources in an integrated governance structure that enables the best-informed contributions to science from all participants.

Each AMP disease area has a steering committee comprising representatives from the administering NIH Institute, the FDA, industry, and nonprofit foundations. The disease-specific steering committees are managed by the FNIH under the direction of the AMP Executive Committee, which includes leaders from NIH, FDA, participating industry partners, and patient advocacy organizations.

The AMP-AD Steering Committee convenes monthly to discuss project plans and review ongoing progress and milestones. NIA program staff members provide scientific and administrative direction and oversee the cooperative grants that constitute the Target Discovery and the Biomarkers AMP-AD consortia. The AMP-AD program has several working groups that bring together scientists from the academic and industry teams. Face-to-face meetings organized by NIA with support from the FNIH provide an additional venue for communication and coordination.

AMP-AD Governance Structure

This organizational chart shows the Accelerating Medicines Partnership Alzheimer’s Disease governance structure. On the left side, the chart shows the AMP Executive Committee box connecting horizontally to boxes for NIA, the AMP-AD Steering Committee, and Industry and Nonprofit Partners. The NIA box connects vertically to the AMP-AD Steering Committee box and horizontally to boxes for the Target Discovery Consortium and Biomarkers Consortium, both of which say “cooperative agreement grants”. The AMP-AD Steering Committee box, directly under the NIA box, is connected to the Industry and Nonprofit Partners box. The Target Discovery Consortium, Biomarkers Consortium, and Industry and Nonprofit Partners boxes are stacked vertically and all connect horizontally to the Working Groups box at the far right.