A Memory and Organizational Aid Improves Research Consent Capacity in Persons with Alzheimer's Disease: Results of a Randomized, Controlled Trial
This randomized controlled trial tested whether a memory and organizational aid, the MacArthur Competence Assessment Tool, improves Alzheimer’s disease patient performance on measures of capacity and competency to give informed consent. Eighty patients with very mild to early moderate Alzheimer’s disease and 30 cognitively normal older adults were recruited from an NIA-funded Alzheimer's Disease Center using the center's patient database. Based on expert reviews of the interview transcripts, the tool improved the ability of patients with very mild to early moderate Alzheimer’s disease to provide their own informed consent to enroll in an early-phase clinical trial.
Rubright J, Sankar P, Casarett DJ, et al. A memory and organizational aid improves Alzheimer disease research consent capacity: Results of a randomized, controlled trial. American Journal of Geriatric Psychiatry 2010;18(12):1124-32.