Development of a Process to Disclose Amyloid Imaging Results to Cognitively Normal Older Adult Research Participants
The goal of the study was to develop a process to maximize the safety and effectiveness of disclosing positron emission tomography (PET) amyloid imaging results to cognitively normal older adults participating in Alzheimer's disease secondary prevention studies.
The researchers gathered and analyzed data and reached a consensus on the following:
- Text for a brochure that describes amyloid imaging to a person who is considering whether to undergo imaging as part of a clinical trial.
- A process for amyloid PET result disclosure during the trials.
Recommendations include an educational session about the process and expectations, both short and long term. The researchers also advise screening for anxiety and depression to determine suitability to receive amyloid imaging information. Anyone conducting the education sessions should check comprehension and be skilled in communication and recognizing distress. Finally, the study also recommends a process for disclosing results, including telephone follow-up within a few days to assess the impact of the results on the participant, and periodic scheduled follow up assessments for depression and anxiety.
Harkins K, et al. Development of a process to disclose amyloid imaging results to cognitively normal older adult research participants. Alzheimer’s Research & Therapy. 2015;7(1):26. doi: 10.1186/s13195-015-0112-7.