The purpose of the Aging Interventions Testing Program (ITP) is to test, under standardized conditions in multiple sites, potential intervention strategies which may decelerate the rate of aging in mammals. The rate of aging is to be measured by lifespan extension and/or improvements in health at later ages due to the intervention. The ITP has used life span as its primary outcome for an intervention, with limited studies on end-of-life pathologies and selected tests of health across the lifespan (health span). This FOA calls for renewal and expansion of the ITP with the following goals: 1. Continue to test compounds for effects on lifespan; 2. Increase analysis of pharmacodynamics and pharmacokinetics of compounds proposed for lifespan studies, including studies of optimal effective dose; 3. Increase histology and pathophysiology analyses at time-of-death; 4. Increase focused studies of health span on selected compounds; 5. Establish a data coordinating center.