This initiative invites applications for funding to conduct a randomized clinical trial of a multifactorial strategy for preventing serious fall-related injuries among non-institutionalized older persons. A multifactorial strategy should be designed for maximal potency in reducing the rate of serious fall-related injuries, which (if found to be effective in the trial) is feasible for future implementation with fidelity in practice in at least one type of care setting. The trial should test an evidence-based protocol that articulates decision rules that address: screening the population to identify individuals at high risk for falling, assessing high-risk individuals to define their specific risk factors, selecting interventions to ameliorate each persons risk factors, implementing these interventions, coordinating the delivery of each persons set of interventions (including methods for coordinating decisions on possible adjustments in medication prescribing among multiple prescribers for a given patient), monitoring each persons progress toward risk factor reduction, and implementing alternative interventions to overcome lack of progress and mitigate new risk factors. The study should incorporate patients and other relevant stakeholders priorities and perspectives in the specification of the study protocol and the outcomes to be measured. Applicants should consider adaptive study design features that facilitate "learning" from accumulating positive or negative evidence.