Purpose. The Research Project Grant (R01) is an award made to an institution/organization to support a discrete, specified, circumscribed project to be performed by the named investigator(s) in areas representing the specific interests and competencies of the investigator(s). The R01 research plan proposed by the applicant institution/organization must be related to the stated program interests of one or more of the NIH Institutes and Centers (ICs) based on descriptions of their programs. All research project grant applications described in this announcement will be assigned to NIH ICs according to standard Public Health Service (PHS) referral guidelines and specific program interests. Investigators are encouraged to consult the participating NIH ICs and their Web sites (see http://www.nih.gov/icd ). Mechanism of Support. This FOA will utilize the Research Project Grant (R01) grant mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Budget and Project Period.Costs appropriate for the project and a project duration of up to five years may be requested. Application Research Strategy Length: The R01 application Research Strategy section of the PHS398 may not exceed 12 pages, including tables, graphs, figures, diagrams, and charts. See Table of Page Limits.