NIA's Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs support small business concerns (SBCs) and nonprofit research organizations that conduct research proximately leading to the development of products and services that improve the health and well-being of older Americans.
The goal is to translate research on aging, aging-related medical conditions and diseases, and special problems and needs of older Americans into innovative programs, systems, networks, and other products or services needed by health-care professionals, informal caregivers, and older Americans to maintain and/or improve their health, and to maintain and/or improve their overall sense of well-being.
All applicants are expected to develop, implement, and test the efficacy of their products and services. The SBIR-STTR programs target early-stage research and research development and encompass a broad range of research topics and types of research/research development, including translational research/research development and secondary research/research development.
The SBIR and STTR programs consist of three phases: Phase I, Phase II, and Phase IIB.
In the SBIR (R43 activity code) and STTR (R41 activity code) programs, Phase I research and development focus primarily on the development and feasibility-testing of prototypes.
In Phase II research and development, SBIR (R44 activity code) and STTR (R42 activity code), SBCs propose and conduct research and development that often features between-group comparisons and further demonstrates the hypothesized features-benefits of the health- and aging-focused prototype product and/or service,
In the Phase IIB program, open to both SBIR and STTR Phase II grantees, SBCs propose and conduct research and development that require extraordinary time and effort and may or may not require FDA approval for the development of such projects, including drugs, devices, vaccines, therapeutics, and medical implants related to the mission of NIA.
Furthermore, applicants to NIH-NIA's SBIR and STTR programs also may submit applications to NIH's SBIR-STTR Fast-Track program. In a Fast-Track application, the applicant SBC submits Phase I (either STTR R41 or SBIR R43) and Phase II (either STTR R42 or SBIR R44) applications in the initial application. The NIH Fast-Track program provides for simultaneous peer & secondary review of both the Phase I and Phase II application.
The simultaneous review and consideration for funding affords Fast-Track applicants the opportunity to plan and subsequently stage the proposed research and development across both Phase I and Phase II and, if a meritorious Fast-Track application is approved for funding, allows the SBC to obtain funding for the Phase II research and development more quickly than it would were it to apply separately (and consecutively) for a Phase I and then a Phase II award.
In 2015, SBCs that have already completed the kind of research and development characteristic of Phase I projects now have the opportunity to submit an SBIR application to the NIH-NIA SBIR Direct-to-Phase-II program. The SBIR Direct-to-Phase II grant mechanism is intended to facilitate SBIR-type research and development, to expand research and development opportunities for applicant small business concerns (SBCs), and to enhance the pace of technology development and commercialization.
Potential applicants are strongly encouraged to refer to and closely read the comprehensive and detailed SBIR-STTR programmatic information and guidance posted to and readily accessible on the NIH SBIR-STTR Web site: https://sbir.nih.gov .
NIA particularly encourages potential applicants to refer to & closely read the 2016 NIH SBIR and STTR Omnibus Solicitations, the 2016 NIA SBIR-STTR Research Topics, and the 2016 NIH SBIR Direct-to-Phase-II FOA:
In addition, in 2016 NIH-NIA lauched the SBIR-STTR Commercialization Readiness Pilot programs, which consist of two FOAs addressing post-Phase-II award technical and late-stage research and development :
Finally, with NIA's recent supplemental budget to address research on Alzheimer's disease (AD) and AD treatments, NIA has published two AD-specific SBIR-STTR FOAs (Program Announcements):
After referring to and reading the NIH SBIR Web site, particularly the 2016 SBIR-STTR Omnibus Solicitations, the NIA SBIR-STTR Research Topics, the SBIR Direct-to-Phase-II Solicitation, and the two AD SBIR-STTR FOAs, potential applicants are further encouraged to contact NIA's SBIR-STTR Program Coordinator to determine if their potential SBIR-STTR research and development would be appropriate for NIA.
Michael-David A.R.R. Kerns, M.M., M.S., Ph.D.
NIA SBIR-STTR Program Coordinator
National Institutes of Health: National Institute on Aging
Email: firstname.lastname@example.org 
Applicant organizations (small business concerns; SBCs) must complete and maintain the following registrations as described in the SF 424 (R&R) Application Guide to be eligible to apply for or receive an award. All registrations must be completed prior to the application being submitted. Registration can take 6 weeks or more, so applicants should begin the registration process as soon as possible. The NIH Policy on Late Submission of Grant Applications  states that failure to complete registrations in advance of a due date is not a valid reason for a late submission.