A Program Project  Grant (PPG or P01) supports synergistic research. It is made up of at least three subprojects and one or more cores, the latter serving some or all subprojects. The PPG allows investigators with differing areas of expertise to collaborate in research by pooling their talents and resources, to produce results that would not be possible with individual, independent projects.
Reviewers are asked to assess the merit of individual subprojects and cores, as well as the overall program project. Each subproject should initially be assessed as if it were an individual stand-alone application. Considerations of how each subproject fits into the overall program project should subsequently be reflected in the overall program project score.