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Nutritional Interventions to Promote Healthy Aging Agenda

September 5-6, 2017
Lister Hill Auditorium
Bldg 38A, NIH Campus
Bethesda, MD

September 5, 2017

8:00 a.m.-8:15 a.m.
Welcome and Workshop Goals
Giovanna Zappalà, Evan Hadley, NIA

8:15 a.m.-12:15 p.m.

Forum I. Caloric Restriction and Amino Acid Restriction

Panel A - Human Studies

Sai Krupa Das: Overview of CALERIE findings – Phase 1 and 2
Kevin Hall: Use of weight data to measure adherence in human trials of caloric restriction
Dennis Villareal: Effects of CR in different age groups & Comparison of CR with exercise effects
Luigi Fontana: CRonies - Long-term CR effects, Effects of higher degrees of CR & Effects of CR on aging mechanisms

BREAK

Panel B - Laboratory Animal Studies of Calorie and Amino Acid Restriction: Implications for Future Human and Lab Animal Studies

Roz Anderson: Implications of nonhuman primate CR studies for human CR studies
Julie Mattison: Future needs for measures in nonhuman primate studies of CR and other dietary interventions
Chris Hine: Advances in understanding of aging mechanisms in rodents: Implications for human studies
Rochelle Buffenstein: Implications of comparative rodent biology for studies of CR and amino acid restriction
Thomas Gettys: Effects of essential amino acid restriction on metabolic health

12:15 p.m. - 1:15 p.m.

Lunch

1:15 p.m. - 3:10 p.m.

Forum II. Differing Patterns of Fasting: Periodic Fasting, Intermittent Fasting, Time-Restricted Feeding

Krista Varady: Alternate-day fasting and other alternative fasting regimens: effects on age-related risk factors
Mark Mattson: Importance of the 'metabolic switch' in the health benefits of energy restriction protocols
Roman Kondratov: Interactions between calorie restriction and circadian clocks
Satchidananda Panda: Relationships of temporal feeding patterns to disease risk factors and physiologic outcomes in humans

3:10 p.m. - 3:20 p.m.

Break

3:20 p.m. - 5:45 p.m.

Forum III - Differing Macronutrient Regimens and Dietary Patterns / Composition

Samantha Solon-Biet: Relationships of levels and proportions of dietary macronutrients to aging outcomes in laboratory animals
David J.A. Jenkins: Legumes as a protein source in plant based nutrition for healthy longevity

Break

Edward Giovannucci: Evidence from human observational studies on effects of dietary constituents on inflammation and other aging-related processes
Neal Barnard: Whole-food plant-based nutrition interventions for the prevention of age-related chronic diseases
Bradley J. Willcox: The traditional Okinawan diet, caloric restriction, and healthy aging: Evidence from Centenarians

5:45 p.m.

Adjourn

September 6, 2017

8:00 a.m. - 8:05 a.m.
Travel Logistics

8:05 a.m. - 10:15 a.m.

Forum IV - Interplay Between Affective and Cognitive Factors and Dietary Change: Factors Affecting Adherence, Factors Affected by Dietary Change

Don Williamson: Adherence strategies for weight loss and caloric restriction
Corby Martin: Effect of calorie restriction on psychological outcomes and eating attitudes and behaviors: Implications for interventions
Cary Savage: Motivational processes to affect eating behaviors and decision making
Bonnie Spring: Technologies to support tracking, self-regulation, and behavior change
Gabrielle (Brie) Turner-McGrievy: Emerging strategies for clinical intervention studies to change diet composition

10:15 a.m. - 10:25 a.m.

Break

10:25 a.m. - 11:55 a.m.

Forum V – Design, Analytic, and Measurement Issues for Nutritional Interventions

Panel A

Rafa de Cabo: Comprehensive measures to assess longitudinal aging changes in laboratory rodents
Lawrence Appel: Design considerations for trials of dietary change
David Allison: Causal modeling in assessing effects of nutritional interventions

11:55 a.m. - 12:55 p.m.

Lunch

12:55 p.m. - 2:25 p.m.

Panel B (Forum V)

Mark Espeland: Selection of outcomes for assessing nutritional interventions to influence aging processes
William Kraus: Extrapolating dietary effects on cardiometabolic risk factors to hard cardiovascular outcomes: Implications for future studies
Susan Roberts: Studies of calorie restriction on aging factors: Implications for obesity prevention studies

2:25 p.m. - 3:30 p.m.

Open Discussion on Research Needs and Opportunities

3:30 p.m.

Adjourn

Information for Remote Participants

This event may be streamed live through WebEx. Information on how to access it remotely may be provided upon request.