Topics of Interest: Resveratrol
Resveratrol is a natural compound found in common foods like grapes, wines and nuts. It activates a family of enzymes called sirtuins. Studies over the last few years have found that resveratrol can extend lifespan in yeast, worms, flies, and fish. The compound mimics the effects of calorie restriction in reducing oxidative stress on cells and organs.
In 2006, a collaborative study between labs at the NIA and at Harvard Medical School found that overweight aged male mice whose high-calorie diet was supplemented by resveratrol had better health and survival than aged overweight mice who did not receive it. This was the first study to show that resveratrol could affect the health and survival of mammals.
Since then, additional research has been conducted on resveratrol, notably by NIA and the Harvard group. The compound has received a lot of publicity in the mass media and can be purchased as a food supplement. Consumers should view these supplements with a good deal of caution and doubt. Some harmful side effects already have been discovered; additional research may uncover others.
For more background information, see the NIA Tip Sheet, Can We Prevent Aging?
See NIA research news related to Resveratrol below.
NIH researchers find Resveratrol helps protect against cardiovascular disease in animal study
June 3, 2014
Resveratrol, a compound found in nuts, grapes, and wine, may protect against certain cardiovascular problems, according to an NIA study in nonhuman primates. Specifically, researchers found resveratrol prevented arterial stiffening and...
Resveratrol does not affect health, longevity in population study
May 16, 2014
Resveratrol, a compound in red wine, grapes, and nuts, has been the focus of many studies for its effects on aging and disease. Researchers have found it to improve the health (and in some cases, longevity) of animals, including mice and...
NIH researchers find resveratrol helps protect against diabetes in animal study
August 8, 2013
Resveratrol, a compound in nuts, grapes, and wine, has been previously found to slow age-related health decline in mice on a standard diet and improve health and longevity of overweight, aged mice on a high fat diet. In a new study of non-...
Compound improves health, increases lifespan of obese mice
August 18, 2011
Researchers have reported that obese male mice treated with a synthetic compound called SRT1720 were healthier and lived longer compared to non-treated obese mice. The experimental compound was found to improve the function of the liver,...
Resveratrol found to improve health, but not longevity in aging mice
July 3, 2008
Scientists have found that the compound resveratrol slows age-related deterioration and functional decline of mice on a standard diet, but does not increase longevity when started at middle age. This study, conducted and supported in part...
Study demonstrates improved health, survival in aged overweight male mice on resveratrol
November 1, 2006
Overweight aged male mice whose high calorie (fat) diet was supplemented by resveratrol, a natural compound found in common foods like grapes, wines and nuts, had better health and survival than aged overweight mice who did not receive it...