Topics of Interest: Calorie Restriction

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Since the 1930s, investigators have consistently found that laboratory rats and mice live up to 40 percent longer than usual and also appear to be more resistant to age-related diseases when fed a diet that has at least 30 percent fewer calories than they would normally consume. Now researchers are exploring whether and how caloric restriction will affect aging in monkeys and other nonhuman primates.

NIA has also begun preliminary studies of calorie restriction in people. A pilot study tested 6 months of calorie restriction on 48 people and provided the basis for the 5-year CALERIE study. This study involves 250 healthy volunteers ages 25 to 45 and is being conducted at Pennington Biomedical Research Center in Baton Rouge, Tufts University in Boston, and Washington University in St. Louis.

See NIA research news related to Calorie Restriction below.