Topics of Interest: Alzheimer's
Impaired clearance, not overproduction of toxic proteins, may underlie Alzheimer's disease
December 9, 2010
In Alzheimer's disease, a protein fragment called beta-amyloid accumulates at abnormally high levels in the brain. Now researchers funded by the National Institutes of Health have found that in the most common, late-onset form of...
Mouse study shows effect of blood pressure drug on Alzheimer’s disease
November 15, 2010
A drug used decades ago to treat high blood pressure has been shown to improve learning and memory in mouse models of Alzheimer’s disease, according to a new study by researchers at the National Institute on Aging (NIA), part of the...
Alzheimer's Disease Neuroimaging Initiative enters next phase of research
October 21, 2010
The National Institutes of Health is expanding the Alzheimer’s Disease Neuroimaging Initiative (ADNI), a groundbreaking study that will recruit hundreds of new volunteers to help define the subtle changes that may take place in the...
Allopregnanolone reverses memory loss in mouse model of Alzheimer's
June 15, 2010
Allopregnanolone, a metabolite of the hormone progesterone that is made in the central nervous system, reversed neurological decline and improved performance on memory tests in 3-month-old mice with characteristics of Alzheimer's...
Subjective cognitive impairment could be precursor of further decline
June 15, 2010
The cognitive health of older adults with “subjective cognitive impairment” (SCI) declined faster and further than that of people without SCI over a period of years, a recent study found. The study suggests that very early,...
Gene linked to Alzheimer’s disease plays key role in cell survival
June 10, 2010
Scientists have discovered that a gene linked to Alzheimer’s disease may play a beneficial role in cell survival by enabling neurons to clear away toxic proteins. A study funded by the National Institute on Aging (NIA), part of the...
Recovery funds advance Alzheimer’s disease research
November 23, 2009
American Recovery and Reinvestment Funds are being used to promote the national research efforts to better understand, diagnose and treat Alzheimer’s disease. The National Institute on Aging (NIA), part of the National Institutes of...
Scientists identify two gene variants associated with Alzheimer’s risk
September 8, 2009
In the largest genome-wide association study (GWAS) reported to date involving Alzheimer’s disease, scientists have identified two new possible genetic risk factors for late-onset Alzheimer’s, the most common form of the...
Study shows possible link between secondhand smoke, cognitive impairment
May 12, 2009
A recent article about a population-based study in England reports that exposure to secondhand smoke could increase the odds of older nonsmokers becoming cognitively impaired. In work funded in part by the NIA, researchers measured levels...
PET scans with PiB show beta-amyloid in brains of cognitively normal older adults
May 12, 2009
Two recent NIA-funded studies used novel imaging techniques to explore the possible connection between the buildup of beta-amyloid protein deposits in the brains in living people and the risk of developing Alzheimer’s disease (AD)....