Topics of Interest: Alzheimer's
Genes involved in age-related declines in brain volume may play role in Alzheimer’s disease
April 16, 2012
The hippocampus, a brain region important to learning and memory, gradually loses volume as part of the normal aging process. This loss is significantly accelerated in older people with Alzheimer’s disease, especially if they have...
New study identifies role of large protein fragment in blocking amyloid build-up
April 13, 2012
Plaques made up of abnormal deposits of beta-amyloid protein are a hallmark of Alzheimer’s disease. The toxic buildup begins when the beta-secretase enzyme (BACE), working in concert with a partner enzyme, snips a small fragment of...
New criteria announced for assessing Alzheimer’s disease neuropathology
January 18, 2012
The neuropathology guidelines used since 1997 to diagnose Alzheimer’s disease at autopsy have been updated to reflect a deeper understanding of Alzheimer’s and other dementias. This will help pathologists characterize Alzheimer...
Latest Alzheimer’s Research Progress Report Released
January 17, 2012
2010 Alzheimer’s Disease Progress Report: A Deeper Understanding, the latest annual Alzheimer’s research report from the National Institutes of Health (NIH) , is now available online. Prepared by the National Institute on Aging...
Pilot trial of insulin nasal-spray for Alzheimer’s yields promising results
September 12, 2011
Results of a pilot clinical trial show a nasal-spray form of insulin delayed memory loss and preserved cognition in people with cognitive deficits that range from mild cognitive impairment (MCI) to moderate Alzheimer’s disease....
Alzheimer's diagnostic guidelines updated for first time in decades
April 19, 2011
For the first time in 27 years, clinical diagnostic criteria for Alzheimer’s disease dementia have been revised, and research guidelines for earlier stages of the disease have been characterized to reflect a deeper understanding of...
Studies find possible new genetic risk factors for Alzheimer’s disease
April 4, 2011
Scientists have confirmed one gene variant and have identified several others that may be risk factors for late-onset Alzheimer’s disease, the most common form of the disorder. In the largest genome-wide association study, or GWAS,...
VA expands caregiver support program developed by NIA-funded researchers
February 15, 2011
The U.S. Department of Veterans Affairs (VA) is expanding support nationally to caregivers of veterans with Alzheimer’s disease with a program developed by NIA-funded researchers. The REACH VA (Resources for Enhancing Alzheimer...
Impaired clearance, not overproduction of toxic proteins, may underlie Alzheimer's disease
December 9, 2010
In Alzheimer's disease, a protein fragment called beta-amyloid accumulates at abnormally high levels in the brain. Now researchers funded by the National Institutes of Health have found that in the most common, late-onset form of...
Mouse study shows effect of blood pressure drug on Alzheimer’s disease
November 15, 2010
A drug used decades ago to treat high blood pressure has been shown to improve learning and memory in mouse models of Alzheimer’s disease, according to a new study by researchers at the National Institute on Aging (NIA), part of the...