Understanding of mTOR pathway and lifespan refined in new study
June 25, 2012
Investigators have identified interventions that extend lifespan in model systems. For example, caloric restriction (CR) – a reduction in caloric intake while maintaining adequate nutrition – has been shown to increase insulin...
Alzheimer’s Disease Research Summit offers research recommendations
May 18, 2012
The Alzheimer’s Disease Research Summit 2012: Path to Treatment and Prevention, held May 14-15, 2012, brought together leading experts on Alzheimer’s disease and other complex diseases to identify research priorities and...
Genes involved in age-related declines in brain volume may play role in Alzheimer’s disease
April 16, 2012
The hippocampus, a brain region important to learning and memory, gradually loses volume as part of the normal aging process. This loss is significantly accelerated in older people with Alzheimer’s disease, especially if they have...
New study identifies role of large protein fragment in blocking amyloid build-up
April 13, 2012
Plaques made up of abnormal deposits of beta-amyloid protein are a hallmark of Alzheimer’s disease. The toxic buildup begins when the beta-secretase enzyme (BACE), working in concert with a partner enzyme, snips a small fragment of...
Smoking in middle age is associated with increased rate of cognitive decline in men
March 22, 2012
Men who smoked in middle age experienced more rapid cognitive decline with age than men who had never smoked, according to a recent article in Archives of General Psychiatry. Dr. Severine Sabia and colleagues examined data from the...
Restricted diet may improve survival after surgery
March 22, 2012
A new study in mice found that several days on a restricted diet helped in coping with the stress of surgery. The research, led by Dr. James Mitchell at the Harvard School of Public Health and supported in part by the NIA and the National...
FY 2012 budget and funding outlook for NIA
February 16, 2012
On December 23, 2011, President Obama signed the bill authorizing funding for the federal government through September 30, 2012. Passage and signing of a budget for fiscal year (FY) 2012 was welcome news, allowing NIA and other federal...
Brain imaging shows lifetime cognitive activity may influence Alzheimer’s disease risk
February 1, 2012
Deposits of amyloid protein in the brain are considered a hallmark of Alzheimer’s disease. Now, for the first time, greater levels of cognitive activity—reading, writing, and playing games—have been associated with lower...
NIH, Surgeon General launch Go4Life campaign at Capitol Hill briefing
January 23, 2012
Exercise and physical activity can help promote health and maintain independence, and this is as true for older people as it is for any age group. To encourage baby boomers—and their parents—to get active, the NIH on October 19...
New criteria announced for assessing Alzheimer’s disease neuropathology
January 18, 2012
The neuropathology guidelines used since 1997 to diagnose Alzheimer’s disease at autopsy have been updated to reflect a deeper understanding of Alzheimer’s and other dementias. This will help pathologists characterize Alzheimer...