Scientists zero in on enzyme at work in Alzheimer's disease
February 26, 2001
Experiments in a newly developed mouse model to determine which of two beta secretases in the brain might be principally responsible for developing the destructive plaques of Alzheimer's disease (AD) provide new evidence that the...
Age and preexisting health problems affect the prognosis and treatment options of older breast cancer patients
February 10, 2001
Older women who had other health problems when they were first diagnosed with breast tumors received less aggressive cancer treatment and pretreatment assessments than women who were younger and healthier, according to a new study by the...
Drug decreases blood vessel stiffness in older primates
January 29, 2001
A novel drug that breaks down vascular collagen bonds in the body significantly decreased the stiffness of blood vessels in older non-human primates, according to a study conducted by National Institute on Aging (NIA) scientists and others...
Scientists isolate premature ovarian failure gene
January 20, 2001
A genetic mutation appears to produce eyelid defects in newborns and trigger early onset of menopause decades later. The finding could help researchers decipher how genetic processes during fetal development can have immediate...
Scientists suspect new genetic risk factor for late onset Alzheimer's disease
December 21, 2000
Three new, separate research studies suggest that a gene or genes on chromosome 10 may be risk factors for late onset Alzheimer's disease (AD). The findings, reported in the December 22, 2000, issue of Science, are important new...
Gene mutation extends lifespan in "I'm not dead yet" fruitflies
December 15, 2000
Mutating a single gene can double the lifespan of fruitflies from 37 days to between 69 and 71 days, while maintaining a high level of functioning and fertility. This finding of a research team led by Stephen L. Helfand was supported in...
Low dose estrogen improves bone health with fewer side effects in older women
December 10, 2000
A low dose of estrogen was as effective in reducing bone turnover -- with fewer side effects -- as higher doses when given to a group of healthy women 65 years and older, according to a study published in the December issue of the Journal...
New study links head injury, severity of injury, with Alzheimer's disease
October 23, 2000
A new analysis of head injuries among World War II veterans links serious head injury in early adulthood with Alzheimer's disease (AD) in later life. The study, by researchers at Duke University and the National Institute on Aging (NIA...
Nasal Alzheimer's vaccine successfully tested in mice
October 15, 2000
Nasal administration of synthetic beta amyloid peptide reduces potentially damaging Alzheimer's disease-like plaques in the brains of test mice and may one day be tested in clinical trials for its ability to vaccinate against plaque...
Can menopause change your sex life?
September 15, 2000
Two million American women experiencing menopause this year want to know—how does "menopause" affect sex? According to scientists at the New England Research Institute (NERI) and the University of Massachusetts Medical...
Well-being improves for most older people, but not for all, new federal report says
August 10, 2000
Older Americans are living longer and living better than ever before. But many of those age 65 and older face disability, chronic health conditions, or economic stress, according to a new federal indicators report that describes the status...
Adverse drug events in nursing homes: Common and preventable
August 9, 2000
Medication-related injuries in nursing homes are common and often preventable according to authors of the largest study to date evaluating adverse drug events due to medication errors in U.S. nursing homes. More than half of the 546...
Sociology trailblazer Matilda Riley bids adieu to NIH to continue her career in Maine
June 27, 2000
Sociologist Matilda White Riley, D.Sc., NIH Scientist Emeritus and founder of the National Institute on Aging's Behavioral and Social Research Program, is returning to her home in Maine. Dr. Riley, 89, will become Research Professor in...
Life expectancy in G-7 industrialized nations may exceed past predictions, study suggests
June 14, 2000
The life expectancy of people in the "G-7" (Group of 7) industrialized nations -- Canada, France, Germany, Italy, Japan, the United Kingdom, and the United States -- may be greater than previously thought, according to a new...
Proteins involved in accelerated aging and DNA repair discovered
May 31, 2000
Researchers at the National Institute on Aging (NIA) have found that the protein (WRNp) defective in the premature aging disorder, Werner's Syndrome (WS), forms a stable molecular complex with two proteins known to be involved in DNA...
NIA makes novel clone set immediately available
May 24, 2000
Researchers at the National Institute on Aging have distributed a recently established mouse cDNA microarray/clone set containing more than 15,000 unique genes to 10 designated academic centers worldwide. These centers have each agreed to...
Secretary Shalala announces four new members to join the National Advisory Council on Aging
February 10, 2000
DHHS Secretary Donna E. Shalala has appointed of four new members to the National Institute on Aging's (NIA) National Advisory Council on Aging (NACA), which advises the secretary on the conduct and support of biomedical, social and...
Low-dose prednisone found ineffective against Alzheimer's disease; researchers continue to look at NSAIDs, other drugs
February 7, 2000
A low-dose regimen of the steroid prednisone, an anti-inflammatory drug, is not effective in the treatment of Alzheimer's disease (AD), according to findings from a new clinical trial. The report, one of the first from a number of...
NIA to study COX-2 inhibitor, other NSAID as new treatment for Alzheimer's disease
February 7, 2000
The National Institute on Aging (NIA) is launching a clinical trial to determine whether treatment with certain nonsteroidal anti-inflammatory drugs (NSAIDs) will slow cognitive and clinical decline in patients with Alzheimer's disease...
"Untangling" tau: New mouse model shows key feature of Alzheimer's disease
November 23, 1999
Scientists have succeeded in producing a hallmark of Alzheimer's disease in a laboratory animal model. The much-anticipated transgenic mouse model is genetically-engineered with the human gene coding for a form of the brain protein tau...