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Nutritional Interventions to Promote Healthy Aging Workshop Information

Tuesday, September 5th, 2017 to Wednesday, September 6th, 2017

Event Location

Lister Hill Auditorium
National Library of Medicine
8600 Rockville Pike, NIH Building 38A
Bethesda, MD 20894

Meeting Description

The “Nutritional Interventions to Promote Healthy Aging” workshop will explore research needs relating to possible clinical trials of different nutritional interventions that have been shown or proposed to influence mechanistic pathways and/or biological mediators influencing aging processes. The workshop will discuss potential follow-up studies to the CALERIE trial and will further explore other types of nutritional regimens which may influence human health span. It will also consider clinical translational research opportunities based on different types of dietary interventions demonstrated to affect health and life span in model organisms.

The types of interventions and nutritional variables that the workshop will address are:

  • Dietary Restriction
    • Caloric Intake Level
      • Caloric Restriction: Prescribed Intake
      • Nutrient Dilution
    • Amino-acids Restriction (methionine, cysteine, tryptophan)
  • Timing and Amplitude of Fluctuations in Caloric Intake
    •  Frequency
      • Time-restricted feeding within each day
      • Every-other day fasting 
      • Periodic fasts over weekly/biweekly intervals
    • Amplitude: Minimum and maximum levels of caloric intake
  • Nutrient sources in diet
    • Omnivore – Vegetarian – Vegan
    • Processed/refined food excluded vs. included
  • Protein/Carbohydrate ratio

For each of the above topics, the workshop will review the current literature and identify options for potential intervention studies or clinical trials to improve our understanding of the impact of different nutritional regimens on aging outcomes and disease risk factors, and needs for preliminary research that could inform choices and design of such intervention studies. In addition, attention will be devoted to behavioral factors and/or strategies influencing adherence to various types of nutritional interventions and the feasibility of such studies in humans.

Contact Information

Giovanna Zappalà, Ph.D., M.P.H.
Clinical Gerontology Branch
Division of Geriatrics and Clinical Gerontology
And Office of Nutrition
National Institute on Aging
National Institutes of Health

An official website of the National Institutes of Health