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Molecular mechanisms regulating mammalian aging

Dr. Toren Finkel to speak at the Geroscience Interest Group (GSIG)

What: Seminar with Toren Finkel, Ph.D.

When: Thursday, March 28, 2013, 12:00 PM – 1:00 PM

Where: Lipsett Amphitheater, Building 10, NIH

Title: "Molecular Mechanisms Regulating Mammalian Aging"

The Geroscience Interest Group (GSIG) cordially invites you to the seminar listed above. Dr. Finkel is Chief of the Center for Molecular Medicine in the Division of Intramural Research at the National Heart, Lung, and Blood Institute. Dr. Finkel’s lab investigates the role of cellular metabolism and oxidative stress in aging and age-related diseases. His research has included studies on oxidative homeostasis in stem cell biology, cellular senescence as a model for aging, the role of autophagy in age-related diseases, and interrogating pathways in model organisms to understand their role in mammalian aging. Dr. Finkel is Editor-in-Chief of Drug Discovery Today-Disease Mechanisms and Associate Editor of Circulation Research.

Publications relevant to his seminar:

  • Narayan N, Lee IH, Borenstein R, Sun J, Wong R, Tong G, Fergusson MM, Liu J, Rovira II, Cheng H-L, Wang G, Gucek M, Lombard D, Alt FW, Sack, MN, Murphy E, Cao L, and Finkel T. (2012). The NAD-dependent deacetylase SIRT2 is required for programmed necrosis. Nature, 492: 199-204.
  • Finkel T, Deng C, and Mostoslavasky. (2009) Recent progress in the biology and physiology of sirtuins. Nature, 460: 587-591.

The Geroscience Interest Group (GSIG) is a newly formed trans-NIH group aimed at enhancing opportunities for discussion of the intersection between the biology of aging and the biology of diseases and conditions that are of interest across ICs. It is focused on basic biology, but with a longer view towards translation. If you are interested in learning more, please visit the GSIG website.

The seminar will be videocast and archived in the GSIG website. Sign Language Interpreters will be provided. Individuals with disabilities who need reasonable accommodation to participate in this event should contact Dr. Ron Johnson at or at 301.496.1953 or Dr. Ron Kohanski at or at 301.496.6402.