Research

Mixed pathologies likely cause dementia in the oldest-old

The brains of people who live to age 90 and older—the oldest-old—usually have a mix of pathologies associated with dementia. Alzheimer’s disease-related brain changes are the most common, but other pathologies often found at autopsy include infarcts, Lewy bodies, hippocampal sclerosis, and white-matter disease. For the first time, researchers examined the relationship between the number of pathologies found at autopsy and the severity of dementia in the oldest-old.

Read latest Connections newsletter for Alzheimer’s research news

The Spring 2015 issue of Connections, the e-newsletter from NIA’s Alzheimer’s Disease Education and Referral (ADEAR) Center, is now available!

In the latest issue:

Find information about volunteering for Alzheimer's clinical trials and studies

Researchers are making great advances in identifying potential new ways to help diagnose, treat, and even prevent Alzheimer’s disease. But it will take many people, including older adults, volunteering for research studies and trials to help find the answers. Find out what you can do. Visit our new webpage—Volunteer for Alzheimer’s Research—to:

Physical activity associated with fewer aging brain-related movement problems

Age-related brain lesions known as white matter hyperintensities (WMH) have been linked to movement problems and disabilities in late life. A recent study suggests that physically active older people may have fewer movement problems caused by WMH. The study, supported in part by NIA, was published online March 11, 2015, in Neurology.

Alzheimer’s research news featured in fall 2014 Connections

The Fall 2014 issue of Connections, the e-newsletter from NIA’s Alzheimer’s Disease Education and Referral (ADEAR) Center, is now available!

In the latest issue:

Increased brain activity may compensate for amyloid pathology in older brains

Researchers have long wondered why some older people remain cognitively normal despite having abnormal levels of beta-amyloid in their brains, a hallmark of Alzheimer’s disease. While research has shown that older adults with Mild Cognitive Impairment (MCI), which often leads to Alzheimer’s, frequently have increased activity in the hippocampus compared to their cognitively healthy peers, scientists questioned what the hyperactivity represented. Was it helping to compensate for declining brain function or signaling onset of the disease?

Learn about participating in Alzheimer’s research in new NIH booklet

Many people who have been affected by Alzheimer’s wonder how they can help combat this devastating disease. Volunteering to participate in research is one powerful way. Right now, at least 70,000 volunteers are needed for more than 150 active Alzheimer’s and related clinical trials and studies in the United States. All kinds of people, including healthy older adults, can join in this critical research.

NIH-funded researchers link epigenome changes to Alzheimer’s disease

Two new NIH-supported studies have shown that a person’s epigenome—the chemical modifications, or marks, on our DNA that turn gene activity on and off—may influence Alzheimer’s disease-related changes in the brain.  The two groups of researchers examined brain tissue donated by volunteers with Alzheimer’s and those free of the disease and linked a specific epigenome marker, DNA methylation, with Alzheimer’s pathology in the brain.

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