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We are excited to let you know that NIA has a resource for investigators seeking to analyze biomedical data. The Health, Aging and Body Composition (Health ABC) Study began in 1997 and collected data for 17 years on a cohort of older black and white adults living in Memphis and Pittsburgh. Participants were aged 70-79 at baseline. These data are now online on NIA’s website and available to qualified researchers. We invite you to take a look!

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Harnessing gamma brain waves to clear Alzheimer’s proteins

Animal study tests novel way to influence Alzheimer's-related brain changes

Gamma brain waves—electrical charges that help link and process information from all parts of the brain—are known to slow down in the brains of people with Alzheimer's disease and other neurological or psychiatric disorders. NIH-funded researchers wanted to better understand the relationship between changes in gamma rhythms and Alzheimer's-related cellular changes.

The mighty push for research on Alzheimer’s disease and related dementias continues at NIA. While an earlier blog highlighted the research initiatives we have published, this chapter covers the more recent publication of two training initiatives and four small business-related initiatives.

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As most of you probably know, there has been a big influx of funds for Alzheimer’s disease research, with perhaps more to come. We recently issued several new Funding Opportunity Announcements (FOAs) focused on Alzheimer’s. A burning question in the minds of many scientists is: Can a basic biologist not currently working on Alzheimer’s really expect to receive funds targeted towards Alzheimer’s research?

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Adaptive brain network change supports healthy cognitive aging in rats

Why does our ability to remember fail as we age? Is age-related memory loss normal, or a sign of something worse, like Alzheimer’s disease? A new study in rats suggests that part of the answer may rest on how effectively different parts of the aging brain ‘talk’ to each other. This has been a difficult problem to study in people because the earliest brain changes in Alzheimer’s disease can occur a decade or more before clinical symptoms.

On October 11, 2016, the first manuscript describing a treasure trove of genomic data contributed by members of the Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD) Target Discovery and Preclinical Validation Consortium was published in Nature Scientific Data. The publication of the datasets and their description are part of an NIH-wide effort to bring together big data and experts from diverse disciplines to better understand dementia, as well as other chronic conditions.

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National study reports decreased dementia prevalence

Dementia prevalence among Americans age 65 and older decreased significantly between 2000 and 2012, according to a study published in JAMA Internal Medicine on November 21, 2016. Results from the nationally representative Health and Retirement Study (HRS) found that dementia prevalence decreased from 11.6 percent in 2000 to 8.8 percent in 2012, representing a relative decrease of about 24 percent.

I visited Cleveland over Thanksgiving. In a moment of peace from family conversations, I picked up the local paper. The first story I encountered was a long report on the Health and Retirement Study findings, funded by NIA, showing a substantial decline in U.S. dementia rates in the last 20 years. Then, I encountered a story reporting Eli Lilly’s negative clinical trial results on solanezumab. My immediate conclusion was that, no matter where I go, my job follows me!

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As many of you know, if you’ve been reading this blog, both the Senate and House appropriations committees separately have passed bills calling for large increases in funds to support research on Alzheimer’s disease and related dementias. In fact, we’ve used that advance information to prepare to receive these funds, should they come our way in final legislation. That’s why we’re in the process of publishing many funding opportunity announcements that will take advantage of these funds, and other funds we will have, once we know our final budget.

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Are you ready to let the good times roll in New Orleans at the annual meeting of the Gerontological Society of America (GSA)? We’re looking forward to seeing old friends and making new ones in the Big Easy. We also hope that you’ll take the opportunity to connect with NIA staff at the meeting, during scientific sessions, and in the Exhibit Hall.

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