Frontotemporal Disorders: Information for Patients, Families, and Caregivers
No single test, such as a blood test, can be used to diagnose a frontotemporal disorder. A definitive diagnosis can be confirmed only by a genetic test in familial cases or a brain autopsy after a person dies. To diagnose a probable frontotemporal disorder in a living person, a doctor—usually a neurologist, psychiatrist, or psychologist—will:
- record a person’s symptoms, often with the help of family members or friends
- compile a personal and family medical history
- perform a physical exam and order blood tests to help rule out other similar conditions
- if appropriate, order testing to uncover genetic mutations
- conduct a neuropsychological evaluation to assess behavior, language, memory, and other cognitive functions
- use brain imaging to look for changes in the frontal and temporal lobes.
Different types of brain imaging may be used. A magnetic resonance imaging (MRI) scan shows changes in the size and shape of the brain, including the frontal and temporal lobes. It may reveal other potentially treatable causes of the person’s symptoms, such as a stroke or tumor. In the early stage of disease, the MRI may appear normal. In this case, other types of imaging, such as positron emission tomography (PET) or single photon emission computed tomography (SPECT), may be useful. PET and SPECT scans measure activity in the brain by monitoring blood flow, glucose usage, and oxygen usage. Other PET scans can help rule out a diagnosis of Alzheimer's.
Frontotemporal disorders can be hard to diagnose because their symptoms—changes in personality and behavior and difficulties with speech and movement—are similar to those of other conditions. For example, bvFTD is sometimes misdiagnosed as a mood disorder, such as depression, or as a stroke, especially when there are speech or movement problems. To make matters more confusing, a person can have both a frontotemporal disorder and another type of dementia such as Alzheimer's disease. Also, since these disorders are rare, physicians may be unfamiliar with the relevant symptoms and signs.
Getting the wrong diagnosis can be frustrating. Without knowing their true condition, people with frontotemporal disorders may not get appropriate treatment to manage their symptoms. Families may not get the help they need. People lose valuable time needed to plan treatment and future care. The medical centers listed in Resources are places where people with frontotemporal disorders can be diagnosed and treated.
Researchers are studying ways to diagnose frontotemporal disorders earlier and more accurately. One area of research involves biomarkers, such as proteins or other substances in the blood or cerebrospinal fluid, which can be used to measure the progress of disease or the effects of treatment. Also being studied are ways to improve brain imaging, including seeing the tau protein, and neuropsychological testing. New diagnostic methods under study may help distinguish frontotemporal disorders from other types of dementia.
Fecha de publicación: Febrero 2017
Última actualización: Marzo 24, 2017