Health and Aging

Alzheimer's Disease

National Academies committee sees promising but inconclusive evidence on interventions to prevent cognitive decline, dementia

The public is enormously concerned about dementia and cognitive impairment, and a wide range of programs and products, such as diets, exercise regimens, games, and supplements, purport to keep these conditions at bay. It is difficult for individuals, health care providers and policy makers to ascertain what has been demonstrated to prevent or reduce risk. To help sort through the data and to understand the quality and weight of current evidence for possible interventions, the National Institute on Aging (NIA) at the National Institutes of Health, commissioned experts for an extensive scientific review and to provide recommendations for public health messaging and future research priorities. 

Walking, talking, and thinking about brain and body health

The SHARP study combines walking, social engagement, and reminiscence to help promote cognitive health in older African-Americans. 

Harnessing gamma brain waves to clear Alzheimer’s proteins

Animal study tests novel way to influence Alzheimer's-related brain changes

Gamma brain waves—electrical charges that help link and process information from all parts of the brain—are known to slow down in the brains of people with Alzheimer's disease and other neurological or psychiatric disorders. NIH-funded researchers wanted to better understand the relationship between changes in gamma rhythms and Alzheimer's-related cellular changes.

National study reports decreased dementia prevalence

Dementia prevalence among Americans age 65 and older decreased significantly between 2000 and 2012, according to a study published in JAMA Internal Medicine on November 21, 2016. Results from the nationally representative Health and Retirement Study (HRS) found that dementia prevalence decreased from 11.6 percent in 2000 to 8.8 percent in 2012, representing a relative decrease of about 24 percent.

NIA boosts Alzheimer’s research network with two new centers

The National Institute on Aging (NIA) at NIH is pleased to announce two new additions to its Alzheimer’s Disease Centers Program—a network of researchers and clinicians developing and sharing new approaches and findings to speed discovery in dementia research.

Putting exercise to the test in people at risk for Alzheimer’s

The YMCA and scientists join forces in a new, NIA-supported clinical trial testing aerobic exercise as a way to slow cognitive decline in people with MCI.

NIH award expands landmark Alzheimer’s biomarker study

The Alzheimer's Disease Neuroimaging Initiative (ADNI)—the long-running National Institutes of Health-supported study investigating brain and fluid biomarkers of the disease—enters a new phase of discovery with the launch of ADNI3.

People at genetic risk for Alzheimer’s disease to test prevention drugs

An NIH-supported study will test 2 drugs to prevent or delay Alzheimer’s in people at genetic risk. Read about the latest dementia prevention study.

Brain scans offer insights into loss of money skills

MRI scans show brain changes related to money management skills in older adults. Can researchers identify seniors at risk of losing financial capacity?

Decoding the molecular ties between vascular disease and Alzheimer's

Seeking a better understanding of vascular contributions to Alzheimer's disease, the National Institutes of Health has launched the Molecular Mechanisms of the Vascular Etiology of Alzheimer's Disease (M²OVE-AD) Consortium, a team-science venture to build a nuanced model of Alzheimer's disease that more accurately reflects its many causes and pathways.

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