Announcements

  • December 2, 2015

    As animals, including humans, age or develop brain diseases such as Alzheimer’s, their brain cells may not produce enough energy to remain fully functional. A new study shows that an enzyme, SIRT3, may protect brain cells against stresses believed to contribute to energy loss. Researchers also found that physical exercise increases the expression of SIRT3, helping to protect the brain against degeneration. The results were published online Nov. 19, 2015, in Cell Metabolism.

    Scientists at NIH’s National Institute on Aging Intramural Research Program, Baltimore, used a new mouse model to investigate whether they could aid brain cells called neurons in resisting the energy-depleting stress caused by neurotoxins and other factors. They found a biochemical hero in SIRT3, located in mitochondria, the cell’s powerhouses. SIRT3 is part of the sirtuin family of proteins, which are thought to play an important role in aging, stress resistance, and metabolic regulation.

    The researchers, led by Mark Mattson, Ph.D., of NIA’s Laboratory of Neurosciences, found that mice that did not produce SIRT3 became highly sensitive to cellular stress when exposed to neurotoxins that cause neurodegeneration and cell death. In mouse models of Huntington’s disease and epilepsy, mice with SIRT3 deficiency had greater brain neuron degeneration and associated behavioral symptoms than those with sufficient SIRT3 after exposure to certain toxins.

    In addition, normal mice that exercised on running wheels for 30 days had significantly higher SIRT3 levels in neurons of the hippocampus, a brain region important for learning and memory, than mice that did not exercise. Researchers concluded that running helped protect neurons against cell death in mice by increasing SIRT3 levels.

    The researchers also found that they could protect neurons against stress using a gene-therapy technology to increase levels of SIRT3 in neurons. Neurons without SIRT3 were significantly more vulnerable to toxic stress than those with SIRT3.

    The findings suggest that bolstering mitochondrial function and stress resistance by increasing SIRT3 levels may offer a promising therapeutic target for protecting against age-related cognitive decline and brain diseases.

    Reference: Cheng A., et al. Mitochondrial SIRT3 mediates adaptive responses of neurons to exercise, and metabolic and excitatory challenges. Cell Metabolism. Published online Nov. 19, 2015.

  • December 1, 2015

    This Notice serves to communicate NIH’s priority areas of health economics research.

    Applicants and potential applicants for NIH research grants are advised to consult with NIH program officers in Institutes and Centers (IC) appropriate to their proposed topic if they have questions about the alignment of their research with IC program priorities.

    You may read the full Notice on the NIH Grants website.

  • November 16, 2015

    If you live in a residentially segregated area with comparatively high rates of crime and violence, limited access to healthy foods, and inadequate health care, it's going to affect your health. Public health professionals who ignore this reality do so at our peril, Carl V. Hill says.

    Hill, PhD '05, believes that to address health disparities in the U.S., new steps - and an interdisciplinary team approach - are needed, "because these disparities are created and sustained at environmental, sociocultural, behavioral, and biological levels."

    To read more, go to University of Michigan School of Public Health newsletter “Findings”, Fall 2015 issue.

  • November 16, 2015

    Heidi Williams, Class of 1957 Career Development Assistant Professor in the Economics Department at MIT, was awarded a 2015 MacArthur Fellowship. The citation recognizes her as

    “….an economist unraveling the causes and consequences of innovation in health care markets. Williams combines finely grained empirical observations and custom-designed data collection methods to build entirely new datasets about technological changes in health care. In addition, her creative methods for determining causal inference, and keen understanding of regulatory law, biological science, and medical research, have allowed her to trace the interplay among institutions, market behavior, and public policy–relevant outcomes.“

    https://www.macfound.org/fellows/class/2015/

    During her studies for her PhD, Dr. Williams was a trainee supported by an NIA T32 institutional training grant, led by David Wise. She is now Principal Investigator for a project “Empirical Studies of the Development and Diffusion of Medical Technologies,” managed by NIA with funds from the NIH Common Fund program in Health Economics.

    All of us at NIA/BSR are delighted to congratulate Heidi Williams on this well deserved recognition of her work!

  • November 12, 2015

    The National Institute on Aging has been working to stimulate health disparities research related to aging. An opportunity is currently available for researchers interested in aging, stress, resilience, and health disparities. There are also exciting, new funding opportunities for Alzheimer’s Disease research that focuses on health disparities.

    In July of 2015, the Office of Special Populations successfully posted a Funding Opportunity Announcement for administrative supplements entitled Aging Research to Address Health Disparities. The announcement was intended to expand existing research in specific areas of interest to include development of new measures to facilitate research on the behavioral and social mechanisms leading to disparities in health; addition of sub-group analyses to existing studies; studies focused on racial, ethnic or gender disparities in stress-responses; and studies focused on racial or ethnic disparities in functional, physiologic, or metabolic outcomes across the life span and in old age.

    The administrative supplement supports the NIA’s health disparity goals of (1) understanding environmental and sociocultural factors and related behavioral and biological mechanisms that diminish health and reduce life expectancy for populations that experience health disparities, (2) developing strategies to increase life expectancy among aging adults and improve the health status of elders from underserved and disadvantaged populations, and (3) using research insights and advances to inform policy that reduces health disparities. The parent projects that were supported cover a broad range of research areas (see below).

    We look forward to learning of valuable findings that inform health disparities research related to aging!

    PI Name (Contact) Institution Parent Project Title
    Sun, Liou
    Board of Trustees of Southern Illinois University
    The Effects Of Early Life Nutritional And Hormonal Signals On Mammalian Aging (Health Disparities Admin Supplement)
    Fillingim, Roger B.
    Bradley, Laurence
    Goodin, Burel R.
    University of Florida Board of Trustees
    Ethnic Differences In Responses To Painful Stimuli
    Kasper, Judith
    Thorpe, Roland
    Johns Hopkins University
    Racial Disparities In Mobility Disability Among Older Men
    Mangione, Carol
    Paz, Sylvia
    University of California Los Angeles
    Center For Health Improvement Of Minority Elderly
    Kapteyn, Arie
    Barcellos, Silvia
    Carvalho, Leandro
    University of California Los Angeles
    Roybal Center For Health Decision Making And Financial Independence In Old Age
    Johnson, Sterling C.
    University of Wisconsin-Madison
    Wisconsin Registry For Alzheimer’s Prevention: Biomarkers For Preclinical Ad
    Wharton, Whitney
    Emory University
    Preclinical Alzheimer's Disease Biomarkers: Effects Of Midlife Vascular Factors
    Small, Scott A.
    The Trustees of Columbia University in the City of New York
    Determinants Of Racial Disparities In Alzheimer’s Disease
    Erlandson, Kristine Mace
    University of Colorado Denver
    Barriers And Facilitators To Exercise Maintenance
    Polivka, Barbara J.
    University of Louisville
    Asthma In Older Adults: Identifying Phenotypes And Factors Impacting Outcomes

     

    --Toccara Chamberlain, NIA Office of Special Populations

  • October 23, 2015

    The National Institute on Aging (NIA), a major research component of the National Institutes of Health (NIH) and the Department of Health and Human Services (DHHS), is seeking exceptional candidates for the position of Health Scientist Administrator. This position is located in the Biological Resources Branch (BRB) and the Aging Physiology Branch (APB), in the Division of Aging Biology (DAB), National Institute on Aging. DAB is responsible for the planning, organization and direction of multidisciplinary programs of extramural research on the biology of aging and managing contract-supported resources for the research community. The incumbent in this position serves as the Program Director for grant portfolios in aging physiology (basic biology of aging of the kidney, liver, lung, and other internal organs) and in the development of novel animal models to study aging biology (from hydra to whales). The incumbent will also be required to take training to become a Contracting Officer’s Representative (COR) in order to assist with contracts that provide biological resources to the research community (e.g., aging rodent colonies, cell bank, tissue banks).

    Major Duties

    As a Health Scientist Administrator, the incumbent will:

    • Formulate, develop, and implement the scientific goals and activities of the Program
    • Formulate and recommend program goals and objectives for developing the resources needed to support the nation's potential to support research on aging;
    • Serve as a Health Scientist Administrator with scientific and administrative responsibility for the program to award and monitor grants and other funding mechanisms to support research goals of the aging research community;
    • Attend study section review meetings for research applications assigned to the portfolio under purview; and
    • Serve as alternate COR or COR on resource contracts, managing technical aspects of contracts and providing assistance to the research community using the resources.

    Candidate Qualifications

    Applicants must possess an M.D. and/or Ph.D., or equivalent degree in the biomedical sciences, with experience using mammalian laboratory animal models in cell biology, molecular biology, or animal physiology. Experience in gerontology (aging research) is desirable but not necessary. In addition, the incumbent must have demonstrated skill in interpersonal relationships and administration.

  • October 15, 2015

    Dr. Angus Deaton

    The 2015 Nobel Prize in Economic Sciences has been awarded to National Institute on Aging grantee Angus Deaton, Ph.D., of Princeton University, N.J.

    “The National Institute on Aging is proud to have supported Dr. Deaton’s work for more than 20 years,” said NIA Director Richard J. Hodes, M.D. “His work has examined how circumstances including income inequality and early childhood nutrition influence health and subjective well-being across the life course in the United States and around the world.”

    Deaton’s NIA funded research has focused on measuring poverty among the elderly in the US, the influence of income and inequality on health and mortality in high, middle, and low income countries, as well as the role of work in the decline of health at older ages. His more recent funded work focused on the measurement of subjective well-being, a self-reported quality of life measure. Dr. Deaton has examined the impact of the financial crisis on well-being in the United States as well as how subjective measures of wellbeing vary across people in different societal groups and in different countries. His funded research has been published in high-profile medical and economics journals such as PNAS, Lancet and the American Economic Review.

    Deaton has also received support from the Fogarty International Center at NIH.

    NIA congratulates Dr. Deaton on his outstanding contributions to health science.

  • September 24, 2015

    The ability to suppress inappropriate behavioral responses—known as cognitive inhibitory control—is essential for everyday living. The time required for the brain to inhibit a response is called the stop-signal reaction time. Certain conditions such as Parkinson’s disease, attention deficit hyperactivity disorder, schizophrenia, and even normal aging, can affect cognitive inhibitory control, resulting in a slower stop-signal reaction time.

    Basic studies are underway to help better understand the mechanisms behind this process, which may ultimately lead to new therapeutic targets for people with cognitive problems affecting stop signal reaction times. One new finding, reported online Sept. 14, 2015 in Nature Neuroscience, provides important new insights. Most research to date on cognitive inhibitory control and stop-signal reaction time has focused on the fronto-basal-ganglia circuit, a part of the brain that helps control movement. Now, researchers from the Laboratory of Behavioral Neuroscience at the National Institute on Aging at NIH and Johns Hopkins University provide new evidence that this cognitive function might also be controlled by the inhibition of neurons in another part of the brain, the basal forebrain, the bottom-front part of the brain typically associated with the wake and sleep states as well as with learning and memory. Changes in the basal forebrain have also been associated with age-related cognitive decline, as well as Alzheimer’s disease.

    In the study, investigators trained rats to respond to a sound, but to inhibit their response if the sound was immediately followed by a light signal. Researchers measured the rats’ stop-signal reaction times and recorded neuronal activity in the basal forebrain.

    Researchers found that the neurons in the basal forebrain of rats were silenced—not firing signals—immediately before cognitive inhibitory control. The faster the neurons were silenced, the shorter the stop-signal reaction time. This link was further established when scientists artificially silenced basal forebrain neurons and saw that the rats would no longer respond to sound even when there was no light signal. This suggests that basal forebrain neurons alone are powerful enough to exert cognitive inhibitory control over behavior in the rats.

    Reference: Mayse, J.D., et al., Basal Forebrain Neuronal Inhibition Enables Rapid Behavioral Stopping. Nature Neuroscience. E-pub Sept 14, 2015. doi: 10.1038/22.4110.

  • September 11, 2015

    On September 18, older adults will join the U.S. Surgeon General, the Director of the National Institute on Aging (NIA), fitness expert Donna Richardson, and leaders from a number of agencies and organizations for a fitness walk in the Nation’s capital. The event, which features the NIA Go4Life exercise and physical activity campaign and Step It Up! The Surgeon General’s Call to Action to Promote Walking and Walkable Communities, highlights the importance of exercise and physical activity for healthy aging.

    Who will be there?

    • VADM Vivek H. Murthy, M.D., M.B.A., U.S. Surgeon General, U.S. Public Health Service, U.S. Department of Health and Human Services
    • Richard J. Hodes, M.D., Director, National Institute on Aging, National Institutes of Health
    • Nora Super, Executive Director, 2015 White House Conference on Aging
    • Donna Richardson, Member, President’s Council on Fitness, Sports & Nutrition
    • Representatives from leading aging and health agencies and organizations
    • Older adults from the Washington metro area who are interested in healthy aging and physical activity.

    When and where will it take place? Friday, September 18, 2015. 12:45 p.m. arrival; walk starts promptly at 1:00 p.m. Beginning and ending at the Hubert H. Humphrey Building Plaza, 200 Independence Avenue SW, Washington, D.C.

    Note: In case of rain, the event will be held at the South Interior Building Auditorium, 1951 Constitution Avenue, NW, Washington, D.C. NIA will notify organizations by e-mail and place an announcement on its website by 10 a.m. on September 18, should a decision be made that the event will move indoors to the Interior Department site.

    Go 4 Life Month, September 2015. In collaboration with The White House Conference on Aging.

  • September 4, 2015

    Get up to speed on the latest in Alzheimer’s and dementia.

    Learn what you need to know to inform, educate, and empower
    community members, people with dementia, and family caregivers.

    The National Institute on Aging at NIH (NIA), Administration for Community Living (ACL), and Centers for Disease Control and Prevention (CDC) are pleased to invite you to join the 4th annual free webinar series on Alzheimer’s disease and related dementias for professionals in the public health, aging services, and research networks.

    Free continuing education credit is available (CNE, CEU, and CECH)!

    TO REGISTER for each webinar, go to nih.webex.com and enter the event number listed below for that webinar.

    Webinar 1 - September 2015:
    Alzheimer’s & Dementia: Resources You Can Use

    Tuesday, September 22, 2:00-3:30 pm ET

    Presentation slide deck for Webinar 1 (15.9MB)

    Recording of Webinar 1  (slides and audio - please note that the audio begins at the 3:15 mark
    Transcript of recording

    Take a quick tour of the latest resource information on Alzheimer’s disease and related dementias, including:

    • What's new with the Federal Government's National Alzheimer’s Plan
    • Updates on information and support resources
      • for consumers and families
      • for caregivers
      • for service providers and other professionals
    • New resources on brain health and research participation

    Presenters:

    • Ruth Drew, MS, Director of Family and Information Services, Alzheimer’s Association
    • Jennifer Watson, MA, Senior Public Affairs Specialist, NIA
    • Amy Wiatr-Rodriguez, MSW, Aging Services Program Specialist, ACL

    Webinar 2 - October 2015:
    What’s Happening in Alzheimer’s Research?

    Wednesday, October 21, 2:00-3:30 pm ET

    Presentation slide deck for Webinar 2 (19.2MB)

    Recording of Webinar 2 (slides and audio)
    Transcript of recording

    Get an overview of current Alzheimer’s research directions and studies, presented by leaders in the field. Learn about:

    • The research plan to cure, treat or prevent Alzheimer’s and related dementias by 2025
    • Engaging participants in studies through the Brain Health Registry
    • Investigating how exercise and diet affect dementia risk
    • Using technology to monitor, manage and study dementia and novel, early predictors of risk

    Presenters:

    • Suzana Petanceska, PhD, Program Officer, Division of Neuroscience, NIA
    • Michael Weiner, MD, Professor in Residence in Radiology and Biomedical Imaging, Medicine, Psychiatry, and Neurology, University of California San Francisco
    • Laura Baker, PhD, Associate Professor in Gerontology and Geriatric Medicine, Wake Forest University
    • Martha Clare Morris, ScD, Director, Section of Nutrition & Nutritional Epidemiology, Department of Internal Medicine, Rush University
    • Jeffrey Kaye, MD, Director, Layton Aging and Alzheimer's Disease Center, Oregon Health & Science University

    Webinar 3 - November 2015:
    Caregivers Supporting People with Dementia: New Research and Technology

    Tuesday, November 17, 2:00-3:30 pm ET

    Presentation slide deck for Webinar 3 (11.6MB)

    Recording of Webinar 3 (slides and audio)
    Transcript of recording
     

    Learn more about dementia caregivers and the latest in tools and strategies to support them, including:

    • How the experiences of caregivers for people with dementia differ from those who care for people with other conditions
    • Innovative resources, including care planning tools and new technologies
    • New directions in respite-related research

    Presenters:

    • Moderator: Erin Long, MSW, Aging Services Program Specialist, ACL
    • Darby Morhardt, PhD, LCSW, Research Associate Professor in Cognitive Neurology and Alzheimer's Disease Center, Northwestern University
    • Alicia Blater, MS, Family Caregiver Support Program Consultant, Lifespan Respite Project Director, North Carolina Division of Aging and Adult Services
    • Jill Kagan, MPH, Program Director, ARCH National Respite Network and Resource Center
    • Carol Farran, PhD, Professor, Rush University Medical Center/Rush College of Nursing

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