• September 11, 2012

    NCI is Participating in PA-12-271, Potential Effects of Metformin on Aging and Age-Related Conditions: Small-Scale Clinical Studies and Secondary Analysis of Controlled Clinical Studies (R01).

    This Notice is to inform potential applicants that the National Cancer Institute (NCI) of the National Institutes of Health (NIH) has joined PA-12-271, entitled “Potential Effects of Metformin on Aging and Age-Related Conditions: Small-Scale Clinical Studies and Secondary Analysis of Controlled Clinical Studies (R01).”

    Additional information is available at

  • September 4, 2012

    Participation of NCCAM in RFA-AG-13-003: Secondary Analyses of Comparative Effectiveness, Health Outcomes and Costs in Persons with Multiple Chronic Conditions (R21)
    National Center for Complementary and Alternative Medicine

    The purpose of this Notice is to inform applicants that the NCCAM will participate, effective immediately, in the following NIH Funding Opportunity Announcement (FOA):

    RFA-AG-13-003: Secondary Analyses of Comparative Effectiveness, Health Outcomes and Costs in Persons with Multiple Chronic Conditions (R21). For this FOA, the following goals are of interest to NCCAM:

    • To assess the public health and health cost impact of complementary health approaches in individuals with two or more conditions,
    • To identify potential differences in effectiveness and safety of different complementary or integrative treatment regimens for patients with specific combinations of two or more conditions,
    • To examine alterations in safety or effectiveness of a complementary or integrative treatment for one condition related to the presence of one or more specific coexisting condition.

    NCCAM is interested in meritorious applications responsive to this FOA that fall within its scientific mission. NCCAM intends to commit up to $400,000 total costs in FY 2013. We encourage applications to conduct secondary analyses in datasets that have collected information on the use of complementary or integrative health approaches in individuals with multiple chronic conditions. We are also interested in applications that assess the impact or outcome of utilization of complementary or integrative health approaches.  To facilitate secondary data analyses, NCCAM has posted a list datasets (PDF, 89K) that contain this information.

    Examples of specific research questions or projects of interest to NCCAM include but are not limited to:

    • Evaluation of the impact of specific forms of complementary health care utilization on health outcomes or quality of life in individuals living with HIV or AIDS in addition to at least one other condition (e.g. pain, insomnia, etc).
    • Studies assessing the effect of complementary or integrative medicine use in individuals with chronic pain and sleep difficulties.
    • Examination of whether utilization of complementary or integrative approaches in patients with chronic pain and another health condition impacts utilization of pain medications.

    All other aspects of this FOA remain unchanged.

  • August 28, 2012

    Notice Number: NOT-OD-12-140

    This Notice announces a new Special Council Review (SCR) policy to help NIH effectively manage resources. The policy will require NIH Institute and Center (IC) Advisory Councils to perform additional review of grant and cooperative agreement applications from Program Director(s)/Principal Investigator(s) [PD(s)/PI(s)] who receive $1.0 million per year in direct costs from active NIH awards. This policy does not represent a cap on NIH funding.

  • August 28, 2012

    The National Institute on Aging (NIA) Interventions Testing Program (ITP) investigates dietary supplements purported to extend lifespan and/or delay the onset of disease and disability.  The NIA ITP tests such compounds in mice, using a variety of measured endpoints to assess the efficacy of interventions.  The NIA ITP is not a mechanism for funding sponsors’ laboratories to perform the work, but rather it is a collaborative effort between the three NIA-funded testing sites and the sponsors who propose interventions for study.  The sponsor’s role is to provide the rationale for investigating the intervention, make recommendations on the dose, route and timing for administration of the intervention, and propose assays and measurements to document the efficacy of the intervention.  The sponsor will have access to all data developed from the treated mice, will assist in analysis of the data and will be a co-author on resulting publications.  Proposals are reviewed by an Access Panel and accepted protocols are prioritized by the ITP Steering Committee.


    The NIA ITP is soliciting proposals for compounds to enter the study in 2013.  The deadline for receipt of proposals is September 21, 2012. 


    Information on the NIA ITP and guidelines for proposal development are posted at:

    Questions may be directed to Dr. Nancy Nadon (

  • August 28, 2012

    The NIH Director’s Early Independence Awards (EIA) initiative allows exceptional junior scientists to accelerate their transition to an independent research career by “skipping” the traditional postdoctoral training. To be eligible, candidates must be within one year (before or after) of completion of their terminal degree or clinical residency at the time of application.


    Additional information, including Frequently Asked Questions about the Early Independence Awards initiative is available at:

  • August 28, 2012

    The CDC has issued new guidelines for hepatitis C testing, focusing on people born during 1945–1965, a population with a disproportionately high prevalence of HCV infection and related disease. CDC is now recommending all baby boomers receive a one-time hepatitis C test. “A one-time blood test for hepatitis C should be on every baby boomer’s medical checklist,” said CDC Director Thomas R. Frieden, M.D., M.P.H. “The new recommendations can protect the health of an entire generation of Americans and save thousands of lives.”

    For more information, see the CDC press release at:

  • August 15, 2012

    The NIA’s GEMSSTAR – Grants for Early Medical/Surgical Specialists' Transition to Aging Research – program is winning rave reviews for enabling physicians just starting out in their careers to connect their specialty to aging research. The NIA is encouraging applications to this important clinical research program.

    “The GEMSSTAR program is an amazing opportunity for physicians from outside the field of geriatrics to delve into aging research that is aligned with their subspecialty,” says Dr. Melissa Simon of Northwestern University’s Feinberg School of Medicine in Chicago and a 2011 GEMSSTAR grantee. “With the aging of the population and the relative lack of a geriatrics trained workforce, now more than ever, it’s essential that more subspecialists obtain training and consider research in geriatrics and gerontology.” Dr. Simon is examining whether caregivers of older family members are interested and able to pursue careers in health care, based on their experiences as informal caregivers.

    “Most older adults don’t receive their health care from a geriatrician; instead, they see their family practitioner, internist, or other specialist,” says Dr. Basil Eldadah, acting chief of the Geriatrics Branch in NIA’s Division of Geriatrics and Clinical Gerontology. “We want to develop aging research capacity among physicians who are trained in other clinical specialties. By tackling an important research problem at the intersection of aging and their particular specialty, these clinicians can carve an important niche in their field. Ultimately, we see our GEMSSTAR grantees developing into future leaders in research that bridges their specialty and aging science.”

    Investigators apply through the GEMSSTAR RFA for 2 years of NIA support using the small research project (R03) mechanism. After peer review of eligible applications, NIA asks each investigator with a meritorious score to submit a Professional Development Plan (PDP). The activities of the PDP would run concurrently with the R03 award and are supported through non-R03 funds.

    “The PDP is a critical element of the GEMSSTAR program,” notes Dr. Eldadah. “It can provide for specific training activities, mentorship, and other career development opportunities. We encourage applicants to seek out sources of support for the PDP as soon as they respond to the RFA.”

    Specialty societies, such as the Association of Specialty Professors and the American Geriatrics Society, are providing assistance for PDPs. Other sources of support can include the applicant’s institution or affiliated Veterans Administration hospital, an Older Americans Independence Center Research Career Development Core, a Clinical and Translational Science Award, or other public or private sources.

    Dr. Una Makris at the University of Texas Southwestern Medical Center in Dallas is another 2001 GEMSSTAR grantee. A rheumatologist, she is studying the social, physical, and psychological impact of back pain in older adults.

    “For many conditions, including back pain, much of the literature focuses on younger working populations,” she says. “Largely, older adults have been excluded from randomized controlled trials so we have little data on which to base our clinical decisions. How do we treat an older person with certain comorbid conditions, taking multiple medications, and what are the outcomes that are most important to older persons?

    “This is an ideal award for a junior investigator who is committed to studying a subspecialty field—in my case, rheumatology—to pursue a feasible, realistic project and launch a career in aging research,” Dr. Makris continues. “The career development portion of this award is unique; importantly, networking with leaders in this field is critical for junior investigators. As a GEMSSTAR awardee, I’m fortunate to meet and network with colleagues in other subspecialties and surgical fields who share a common interest of aging research.”

    There is another potential, major benefit to GEMSSTAR participation, Dr. Eldadah notes. As a unique opportunity to get a foot in the door for early-career physicians interested in bridging their clinical specialty with aging research, it can make a candidate more competitive for subsequent NIH awards. “We hope that eligible applicants will see the value of this program and apply for it this year,” he says.

    The deadline for applications for the program is October 1, with letters of intent due on September 1. For more information on GEMSSTAR, go to The RFA is available at



  • August 14, 2012

    Epigenetics, the study of how the environment modifies the way the human gene is expressed, is an emerging frontier in science. Diet and exposure to environmental chemicals, among other factors, can cause epigenetic changes that may turn on or off certain genes and make people more or less susceptible to developing Alzheimer’s disease and other disorders. Positive factors, such as physical activity and enriched living conditions, may result in beneficial epigenetic changes such as a longer health span or lowered incidence of chronic diseases. These changes in gene function profoundly influence the behavior of cells and tissues and play a role in neurobiological and cognitive processes, including learning, memory, circadian rhythm, and neurodegeneration.

    Until now, little was known about how various epigenetic processes differ across different brain regions, or how the effects of those processes may influence brain activity. NIA-supported researchers investigated DNA methylation, one type of epigenetic modification that can control the level at which a gene is expressed, to produce the first annotated map of patterns of DNA methylation in the brain. Using blood samples and postmortem brain tissue from donors older than age 75 and free of any neuropathology and neuropsychiatric disease, they were able to demonstrate marked differences in methylation in six areas of the brain.

    Notably, the investigators at King’s College London, and Baylor College of Medicine, Houston, found increased rates of methylation in regions involved in nervous system development and function and in neurogenesis. Research like this may, one day, result in our ability to investigate epigenetic processes in the brain by studying DNA methylation patterns in readily accessible blood samples.

    The data generated in this project are available as a resource to the genomics research community through several avenues, including integration into the Human Epigenome Atlas as part of the regular data release by the NIH Epigenomics Roadmap Initiative.

    Reference: Davies, M., et al. Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood. Genome Biology 2012, 13:R43

  • August 7, 2012

    Every day can bring a new change or challenge for caregivers of people with Alzheimer’s disease. Now, practical information and advice is at hand with a new series of online tip sheets from the Alzheimer’s Disease Education and Referral (ADEAR) Center, a service of the National Institute on Aging (NIA).

    Based the NIA publication called Caring for a Person with Alzheimer’s Disease: Your Easy-to-Use Guide from the National Institute on Aging, the tip sheets offer reliable, easy-to-understand information on a range of issues. They can help caregivers of people at any stage of the disease—mild, moderate or severe.

    Topics include managing personality and behavior changes, coping with agitation and aggression, daily activities, managing medicines, helping family and friends understand Alzheimer’s, and many more.

    To read the tip sheets, visit

  • July 31, 2012

    The deadline for applications has been extended until August 10th for Taking the Next Step: Grants Technical Assistance Workshop. The workshop is an interactive forum for pre- and post-doctoral students and recent recipients of Ph.D., M.D., or related doctoral degrees with the National Institute on Aging, the world's largest funding source for research on aging and geriatrics. During this intensive 1.5 day workshop attendees will gain an understanding of the NIH grants process from application to award, and NIA staff will discuss research priorities and opportunities in the basic biology of aging, neuroscience, behavioral and social research and clinical geriatrics and gerontology. Attendees will have the opportunity to meet in small groups with NIA staff representative of their field of interest. A session focused on research and funding opportunities in health disparities and aging will highlight this GSA pre-conference workshop.

    See more information and application.