• December 13, 2013

    What does the science say about dietary supplements and complementary and alternative health approaches for Alzheimer's disease, dementia, and cognitive health? While some dietary supplements have been marketed with claims that they enhance memory or improve brain function and health, research is ongoing to determine whether they may have any effect on the progression of cognitive decline or Alzheimer’s disease.

    NIA is co-hosting a Twitter chat with the National Center for Complementary and Alternative Medicine (NCCAM) on Wednesday, December 18 at 4:00pm Eastern Time to talk about what we know and answer questions about ongoing research in this area. In addition, we'll discuss some of the research that’s looking at exercise and other mind and body practices, which have shown promise in treating some symptoms related to dementia, as well as for alleviating stress among caregivers.

    Participating in the chat from @Alzheimers_NIH will be NIA experts Drs. Laurie Ryan and Nina Silverberg and from @NCCAM experts Drs. D. Lee AlekelPartap Khalsa, and Richard Nahin.

    Follow the conversation at #nccamchat.

  • December 11, 2013

    Cartoon of four people in conversation.Each year, the National Institute on Aging publishes a funding policy for medical research grant applications. This policy is of great interest to scientists and researchers seeking funding and others in the research community.

    The interim funding policy and paylines for fiscal year 2014 are now available. In a new blog post, Dr. Robin Barr, director of the NIA Division of Extramural Activities, describes the temporary paylines and how they might change over the course of the year. "Hopefully we will be able to pay more applications once Congress enacts a budget or continuing resolution that covers the entire fiscal year," he explains.

    Read the full blog post: NIA interim payline update

    The NIA blog publishes weekly with information on grants and funding policy, research priorities, scientific meetings, and topics of interest to researchers and others in the scientific community. Subscribe to get it weekly in your email inbox, or grab the RSS feed.

  • December 11, 2013

    Dementia, a loss of cognitive functioning that interferes with independent living, has many possible causes. Two new publications from the National Institutes of Health (NIH) explore the topic:

    • Lewy Body Dementia: Information for Patients, Families, and Professionals sheds light on a specific dementia that affects more than 1 million Americans. The publication describes types of LBD (including dementia with Lewy bodies and Parkinson’s disease dementia), symptoms, diagnosis, and treatment, as well as advice for living with the disease and caregiving.
    • The Dementias: Hope Through Research looks at the range of dementias, including Alzheimer’s disease, vascular dementia, frontotemporal disorders, dementia caused by traumatic brain injury, and others. The publication describes each condition, how dementia is diagnosed and treated, and the latest research.

    These resources are jointly published by the National Institute on Aging (NIA) and the National Institute of Neurological Disorders and Stroke (NINDS), both part of NIH.

    Available FREE:

    For more dementia-related information, visit NIA’s Alzheimer’s Disease Education and Referral (ADEAR) Center at Resources about non-Alzheimer’s dementias, including a booklet about frontotemporal disorders, can be found at

  • December 6, 2013

    Cartoon of four people in conversation.Ever wondered what it's like to work for the National Institute on Aging? Postdoctoral fellow Jennifer Illuzzi has a new blog post about her NIA research job and how it differs from other opportunities available to scientists. "When I was choosing between postdoctoral opportunities after finishing up my Ph.D..." she explains," it’s the training and career development opportunities that most made the NIA stand out."

    Read the full blog post: What's it like to do a postdoc at the NIA?

    The NIA blog publishes weekly with information on grants and funding policy, research priorities, scientific meetings, and topics of interest to researchers and others in the scientific community. Subscribe to get it weekly in your email inbox, or grab the RSS feed.

  • December 5, 2013

    A new report sponsored by the National Institute on Aging at NIH and the U.K. Economic and Social Research Council and produced by the National Research Council, suggested that national surveys might begin to seek information on “experienced” well-being – the self-reported levels of contentment, stress, frustration, and other feelings people experience throughout the day and while performing different activities. These could be tested on a pilot or experimental basis on surveys, to start, to resolve methodological issues in the approach. The report, “Subjective Well-Being: Measuring Happiness, Suffering, and Other Dimensions of Experience,” was issued December 4, 2013, by the National Research Council of the National Academies.

    The report emphasized the importance of gathering survey data on the particular measure of experienced well-being, which includes feeling happy and secure, as well as misery and suffering. Such data would be useful in informing specific actions and policy decisions intended to improve the living and working conditions of different population groups, including children or older adults, and could help in developing specific policies and practices relating to end-of-life care, commuting, child custody laws, city planning, patients undergoing medical treatment, among others.

    Interest in measuring subjective well-being has grown in recent years, as some researchers have begun to question whether traditional economic measures, such as gross domestic product, can adequately reflect the quality of life of a population or country. This report focuses on experienced, or subjective, well-being, but notes that well-informed policy decisions must also consider evaluative and eudaimonic aspects of self-reported well-being. Evaluative well-beingreflects a person’s assessment of his or her overall life satisfaction, while eudaimonic well-being refers to a person’s perceptions of purpose, and the meaningfulness (or pointlessness) of the activities they are engaged in.

    Collecting data on experienced well-being has already begun in some studies of the health and quality of life of older populations in the United States and in other countries. Such measures have already been included in the NIA’s Health and Retirement Study and the Bureau of Labor Statistics’ American Time Use Survey. The report identified other government surveys – such as the American Housing Survey and the Panel Study of Income Dynamics – that could include questions about experienced well-being. The report stated that questions have also been included on a pilot basis in the broader population surveys of the U.S. statistical agencies, as they have been in the United Kingdom.

    “Subjective Well-Being: Measuring Happiness, Suffering, and Other Dimensions of Experience,” is available at
  • November 21, 2013

    Measuring vitamin D binding protein (VDBP) may be important for accurately determining vitamin D deficiency, especially among African Americans, reports a team of researchers led by the National Institute on Aging, NIH, in the November 21, 2013 issue of the New England Journal of Medicine.

    Vitamin D deficiency is more commonly diagnosed among African Americans than in white Americans. However, the poor skeletal-bone health associated with vitamin D deficiency is less common in this population—African Americans generally have higher bone density and lower risk for fragility fractures than white Americans. This suggests that the vitamin D deficiency as it is currently diagnosed is likely inaccurate. With this study, researchers were able to evaluate the potential role of VDBP, the protein that carries vitamin D throughout the body, in assessing clinically significant vitamin D deficiency.

    The team measured levels of vitamin D, calcium, and VDBP, as well as bone density, and analyzed the genetic form of (genotyped) VDBP in NIA’s Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) cohort, a study comprised of community-dwelling blacks and whites initially aged 30 to 64 residing in Baltimore, Maryland. They found that, compared to whites, African Americans had lower levels of vitamin D and VDBP, but higher bone density and higher levels of calcium, another micronutrient important to bone health. Genetic analysis of participants’ VDBP indicated that African Americans were more likely to have one form of the protein and whites another. The version of VDBP more prevalent in African Americans, but also seen in some white participants, was associated with lower levels of the binding protein and lower levels of vitamin D.

    Researchers suggest that low VDBP may have a protective effect against the symptoms typically associated with lower vitamin D levels and clinically relevant vitamin D deficiency. Therefore, rather than diagnosing and treating vitamin D deficiency based on only lower vitamin D levels, clinicians may also want to account for VDBP in their assessment, especially in African Americans. Routine Vitamin D supplementation should be carefully considered in the context of the finding of this study.

    Reference “Vitamin D Binding Protein and Vitamin D Status of Community Dwelling Black and White Americans” by Powe, C.E., Evans, M.K., et al. New England Journal of Medicine. DOI: 10.1056/NEJMoa1306357 (November 21, 2013).

  • November 20, 2013

    Cartoon of four people in conversation.NIA Deputy Director Dr. Marie A. Bernard has a new blog post about mentoring networks, funding opportunities, and support for researchers from diverse backgrounds. If you’re mentoring someone, or if you yourself are one of these junior investigators, you may be especially interested in her new post. "Already underrepresented groups—from a variety of racial and ethnic backgrounds, to individuals with disabilities, and women—often enter the science training pipeline in smaller numbers and drop out at higher rates," she explains. "The NIH and the NIA are working very hard on this issue."

    Read the full blog post: Support for researchers from diverse backgrounds

    The NIA blog publishes weekly with information on grants and funding policy, research priorities, scientific meetings, and topics of interest to researchers and others in the scientific community. Subscribe to get it weekly in your email inbox, or grab the RSS feed.

  • November 18, 2013

    November is COPD Awareness Month and NIA staff and representatives of several other NIH ICs and agencies participated in a recent federal workshop on the disease.

    COPD (chronic obstructive pulmonary disease) is the third leading cause of death in the U.S., with more than 130,000 dying from it each year. COPD typically manifests as chronic bronchitis or emphysema. Many cases of COPD are related to present or past cigarette smoking. COPD is a leading cause of disability in both middle-aged and older people, and frequently causes hospital and intensive care unit admissions. COPD is associated with decreased employment and increased collection of disability insurance.

    At the meeting on May 3, 2013, the group described activities at each participating agency or Institute, and discussed ways to develop and enhance collaborations to improve federal efforts to deal with this disease.

    More information about COPD and federal efforts to address the disease during COPD Awareness Month are available at the NIH and NHLBI websites.

  • November 15, 2013

    Researchers leading the National Institute on Aging’s Intervention Testing Program (ITP) at the University of Michigan in Ann Arbor, the Jackson Laboratory in Bar Harbor, Maine, and the University of Texas Health Sciences Center at San Antonio have found that acarbose, a drug commonly used to treat type 2 diabetes, increases median lifespan of male mice by 22 percent. The drug’s effects were smaller in female mice, producing only a 5-percent increase in lifespan. The effect on maximum lifespan was similar in male and female mice, increasing longevity by 11 percent and 9 percent, respectively.

    In the same paper, published online October 26, 2013, in Aging Cell, researchers report the effects of three other agents on mice lifespan: sex hormone 17-α-estradiol (EST); antioxidant nordihydroguaiaretic acid (NDGA); and dye and antioxidant methylene blue (MB). None had as large an impact on lifespan as acarbose. EST increased male median lifespan by 12 percent, but did not affect maximum lifespan; it had no effect on female lifespan. NDGA increased male median lifespan by 8 to 10 percent at three different doses; but, like EST, had no significant effect on female lifespan. Maximum lifespan data are not yet available. MB had no effect on male lifespan and only a 6–percent increase on female maximum lifespan.

    The researchers say that these findings reinforce the importance of evaluating both males and females in aging studies, since it appears that some interventions have gender-specific effects.

    Acarbose, EST, NDGA, and MB are four of several treatments that have been investigated through the ITP, which studies compounds in mice for their potential to extend lifespan and delay disease and dysfunction. So far, 6 of 18 compounds tested have shown a significant increase in lifespan of at least one sex of mice; other studies are still in progress.  A noteworthy discovery from the ITP was that rapamycin, an immunosuppressant, significantly increases lifespan of both male and female mice, mimicking many of the health benefits of calorie restriction. Learn more about the ITP.

    Reference: Harrison D, et al. Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males. Aging Cell, Epub 26 Oct 2013, DOI: 10.1111/acel.12170.

  • November 14, 2013

    The National Institute on Aging (NIA) is currently recruiting for a Senior Public Health Advisor position.

    ABOUT THE NIA: The NIA conducts, fosters, and supports biomedical, social, and behavioral research and training pertaining to the aging processes and common problems of older people through: (1) research performed in its own laboratories and through contracts; (2) a program of research grants and individual and institutional research training awards; (3) cooperation and collaboration with other Departmental agencies, voluntary organizations, and other institutions; and (4) collection and dissemination of the findings of aging research and studies, and other information about the process of aging. For more information about NIA, please visit our website at


    • Advise the NIA Director, Deputy Director, and senior leadership staff about congressional relations, legislative policy, international activities; including opportunities and potential vulnerabilities for the NIA programs;
    • Analyze, evaluate, and report data in response to special requests from DHHS, NIH, and Congress;
    • Prepare and/or coordinator testimony, in cooperation with NIA scientific staff, for delivery by NIA officials and coordinate and/or prepare other materials in response to congressional inquiries;
    • Serve as an expert and consultant on legislative matters and as a contact for the Institute;
    • Supervise and direct the congressional correspondence function;
    • Prepare presentations and speeches for NIA/NIH officials on legislative policies and aging-related topics;
    • Coordinate meetings in response to requests from congressional staff, members of Congress and representatives of outside organizations;
    • Serve as NIA Liaison to organizations outside of the NIA and NIH, including the General Accounting Office, Congressional Research Service, patient advocacy groups, professional organizations, and scientific organizations;
    • Coordinate the NIA’s international health and aging research activities;
    • Work with other NIH institutes who have ongoing research activities that relate to the goals and mission of the NIA; and
    • Review and analyze reports and proposals produced by other agencies that could effect the NIA and advice NIA leadership on potential policy matters.

    SALARY: GS-15 ($123,758- $155,500)

    LOCATION: Bethesda, MD (NIH Campus)

    QUALIFICATIONS: Specialized experience and a degree in public health or other field of study with course work directly related to the work of the position to be filled. Legislative experience is desirable but not required.

    HOW TO APPLY: Please send cover letters and CV to Ms. Jessica Schwartz at Please contact Ms. Schwartz with questions or concerns at 301-402-7719.

    NIH and NIA are equal opportunity employers. People with disabilities may be eligible under the Schedule A hiring authority, and are encouraged to apply.