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Types of Progressive Apraxia of Speech

Recruiting

This observational study aims to identify and distinguish two different types of progressive apraxia of speech (PAOS), a disorder associated with neurodegenerative disease and dementia, through clinical imaging and testing of adults with PAOS.

Minimum Age Maximum Age Gender Healthy Volunteers
18 Years N/A All No
August 1, 2017
July 31, 2021
47

  • Progressive impairment of speech and evidence of apraxia of speech
  • Speech intelligible enough for acoustic analysis
  • Speak English as primary language
  • Study partner who can provide an evaluation of participant's functioning

  • Speech not intelligible enough for speech-language diagnosis
  • Illness or condition that could account for speech deficits, such as traumatic brain injury, stroke, or developmental syndromes
  • Evidence of another neurodegenerative disease, such as Alzheimer's
  • Aphasia or dysarthria without PAOS or more severe than PAOS
  • Pregnant, postpartum, or breastfeeding; women of childbearing potential must have a pregnancy test within 48 hours of computed tomography (CT) scan
  • Inability to undergo magnetic resonance imaging (MRI), such as metal implants or fragments, pacemaker, or claustrophobia
  • Conditions that may interfere with results on brain imaging studies, such as structural abnormalities, including subdural hematoma or intracranial neoplasm
  • Medically unstable or on medications that might affect brain structure or metabolism, such as chemotherapy

Researchers have identified different characteristics in the speech patterns among people with progressive apraxia of speech (PAOS) and characterized two types, phonetic and prosodic, which may be associated with progression of neurodegenerative disease. This 4-year longitudinal study will track speech, language, and cognitive function in adults with PAOS in order to better characterize the types of PAOS. Researchers also will perform acoustic analyses, brain imaging scans (MRI and CT), and autopsies to better understand the neurobiology and clinical associations of these types of PAOS.

Name City State Zip Status Primary Contact
Mayo Clinic
Rochester Minnesota 55905 Recruiting Sarah M Boland, CCRP
507-284-3863
boland.sarah@mayo.edu

Mayo Clinic

Name Role Affiliation
Keith A. Josephs, MD Principal Investigator Mayo Clinic

Name Phone Email
Sarah M. Boland, CCRP 507-284-3863 boland.sarah@mayo.edu

NCT03313011

The Neurobiology of Two Distinct Types of Progressive Apraxia of Speech