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Trial-Ready Cohort for the Prevention of Alzheimer's Dementia (TRC-PAD)

Recruiting

The Trial-Ready Cohort for the Prevention of Alzheimer's Dementia (TRC-PAD) study will develop a cohort to facilitate rapid enrollment into Alzheimer's prevention clinical trials. Potential participants should first enroll in the APT Webstudy.

Minimum Age Maximum Age Gender Healthy Volunteers
50 Years 85 Years All Yes
June 4, 2019
April 30, 2023
2000

  • Global Clinical Dementia Rating score of 0 or 0.5 and no diagnosis of dementia
  • Study partner who is willing to participate as a source of information and has at least weekly contact (in-person, via telephone, or electronic communication) with the participant
  • Good general health
  • Adequate visual and auditory ability to allow neuropsychological testing
  • Fluent in English or Spanish
  • Females who are not surgically sterile or postmenopausal for 2 years must receive a negative pregnancy test prior to amyloid PET scan
  • Completed six grades of education or has a good work history
  • Evidence of elevated or intermediate levels of brain amyloid, as assessed by amyloid PET or cerebrospinal fluid data; prior amyloid testing results may be used with approval from the Coordinating Center

  • Treatment with another anti-amyloid investigational drug or other intervention within past 12 months
  • Enrolled in another interventional clinical trial within the last 12 weeks
  • Any significant neurological disease such as Alzheimer's disease dementia, Parkinson's disease, multi-infarct dementia, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma
  • Major depression, bipolar disorder, agitation or behavioral problems within the past 3 months that could lead to difficulty complying with the study; history of schizophrenia
  • History of alcohol or substance abuse or dependence within the past 2 years
  • Clinically significant or unstable medical condition, including uncontrolled hypertension, uncontrolled diabetes, or significant cardiac, pulmonary, renal, hepatic, endocrine, or other systemic disease
  • History within the last 3 years of a primary or recurrent malignant disease, with the exception of non-melanoma skin cancers, resected cutaneous squamous cell carcinoma in situ, basal cell carcinoma, cervical carcinoma in situ, or in situ prostate cancer with normal prostate-specific antigen post-treatment
  • Clinically significant abnormalities in vitamin B12 or thyroid function tests
  • Clinically significant abnormalities in laboratory tests or electrocardiogram
  • For participants undergoing cerebrospinal fluid collection, current blood clotting or bleeding disorder

TRC-PAD is an observational study designed to create a group of cognitively healthy volunteers willing to participate in clinical trials aimed at discovering treatments that will reduce the risk of developing Alzheimer's dementia. TRC-PAD will help researchers enroll participants into these trials quickly. Participants must be identified as being at risk for  memory loss caused by Alzheimer's disease based on a number of factors, including family history, performance on memory tests, genetics tests, and biomarker tests.

To join the TRC-PAD study, individuals must first complete an APT Webstudy online questionnaire and memory tests. If selected, participants will make an in-person visit to a study site, where they will complete several assessments to see if they qualify to join the cohort. These assessments include a positron emission tomography (PET) brain scan, cerebrospinal fluid collection, tests of memory and thinking, questionnaires about daily functioning, mood and behavior, genetic testing, and routine blood and urine tests. Individuals who enroll in TRC-PAD will come back to the clinic every 6 months for brief follow-up visits, with questionnaires and testing, until they qualify for a clinical trial.

Name City State Zip Status Primary Contact
University of Alabama
Birmingham Alabama 35294 Not yet recruiting

Banner Alzheimer's Institute
Phoenix Arizona 85006 Recruiting Daniela Tauchmann
602-839-4891
Daniela.Tauchmann@bannerhealth.com
Banner Sun Health Research Institute
Sun City Arizona 85351 Recruiting Nadira Trncic
623-832-6590
Nadira.Trncic@bannerhealth.com
University of California, Irvine
Irvine California 92697 Recruiting Beatriz Vides
949-824-3250
byanez@uci.edu
University of Southern California
Los Angeles California 90033 Recruiting Mauricio Becerra
329-442-7594
Mauricio.Becerra@usc.edu
University of California, San Francisco
San Francisco California 94143 Not yet recruiting

University of California, Davis
Walnut Creek California 945985900 Not yet recruiting

Yale University
New Haven Connecticut 06510 Not yet recruiting

Georgetown University
Washington District of Columbia 200072145 Recruiting Kelly McCann
202-687-0413
keb53@georgetown.edu
Mayo Clinic Jacksonville
Jacksonville Florida 32224 Not yet recruiting

Wien Center for Alzheimer's Disease
Miami Beach Florida 33140 Recruiting Rosemarie A Rodriguez
305-674-2121
Rosemarie.Rodriguez@msmc.com
Brain Matters Research
Stuart Florida 34997 Recruiting Jetliza Lesmes
561-381-9060
jlesmes@ergclinical.com
University of South Florida - Health Byrd Alzheimer Institute
Tampa Florida 336134808 Recruiting Juris Janavs
813-396-0637
jjanavs@usf.edu
Emory University
Atlanta Georgia 30329 Recruiting Phyllis L Vaughn
404-712-6901
pvaughn@emory.edu
Rush University
Chicago Illinois 60612 Recruiting Peter Liambotis
312-563-0523
Peter_J_Liambotis@rush.edu
Indiana University
Indianapolis Indiana 46202 Recruiting Kala Hall
317-963-1867
kalhall@iupui.edu
University of Kansas
Fairway Kansas 66205 Recruiting Debra Brook
901-866-9252
dbrook@kumc.edu
University of Kentucky
Lexington Kentucky 405042681 Recruiting Hope Esposito
859-323-4547
hope.esposito@uky.edu
Johns Hopkins University
Baltimore Maryland 212242764 Recruiting Samantha Horn
410-550-9020
shorn8@jhmi.edu
Brigham & Women's Hospital
Boston Massachusetts 21155804 Recruiting Samantha Kuney
617-732-7992
skuney@bwh.harvard.edu
University of Michigan
Ann Arbor Michigan 48105 Recruiting Lauren Mackenzie
734-232-2415
spearsl@umich.edu
Mayo Clinic Rochester
Rochester Minnesota 55905 Not yet recruiting

Washington University, St. Louis
Saint Louis Missouri 631082215 Not yet recruiting

Cleveland Clinic Lou Ruvo Center for Brain Health
Las Vegas Nevada 891060100 Recruiting Grey Rivera

riverag@ccf.org
University of Rochester Medical Center
Rochester New York 14620 Recruiting Esmeralda Morales
585-760-6562
esmeraldamorales@urmc.rochester.edu
Wake Forest University Health Sciences
Winston-Salem North Carolina 27157 Not yet recruiting Abigail O'Connell
336-716-7976
abigail.oconnell@wakehealth.edu
Case Western Reserve University
Beachwood Ohio 441224312 Recruiting Megan Posan

Megan.Posan2@UHhospitals.org
Oregon Health & Science University
Portland Oregon 972393011 Recruiting Natasha Spoden
503-494-0976
spoden@ohsu.edu
University of Pennsylvania
Philadelphia Pennsylvania 19104 Recruiting Allison Weiss
215-615-3133
allison.weiss@uphs.upenn.edu
Rhode Island Hospital
Providence Rhode Island 02903 Recruiting Quinneil Simmons
401-444-2421
quinneil.simmons@lifespan.org
Butler Hospital Memory and Aging Program
Providence Rhode Island 02906 Recruiting Katherine Daneault
860-908-6738
KDaneault@buttler.org
Roper St. Francis Hospital
Charleston South Carolina 29401 Recruiting Allison Lapp
843-724-2214
allison.lapp@rsfh.com
University of Texas Southwestern Medical Center
Dallas Texas 75390 Not yet recruiting

University of North Texas Health Sciences Center
Fort Worth Texas 76107 Not yet recruiting

University of Washington / Seattle Institute for Biomedical and Clinical Research
Seattle Washington 98108 Not yet recruiting

University of Southern California

  • National Institute on Aging (NIA)
  • Alzheimer's Therapeutic Research Institute
  • Alzheimer's Clinical Trials Consortium
  • Brigham and Women's Hospital
  • Cleveland Clinic Lou Ruvo Center for Brain Health

Name Role Affiliation
Paul Aisen, MD Principal Investigator USC Alzheimer's Therapeutic Research Institute (ATRI)
Reisa Sperling, MD Principal Investigator Brigham and Women's Hospital
Jeffrey Cummings, MD Principal Investigator Cleveland Clinic Lou Ruvo Center for Brain Health

Name Phone Email
APT / TRC Recruitment Team 858-877-3135 info@aptwebstudy.org

NCT04004767

Trial Ready Cohort for the Prevention of Alzheimer's Dementia (TRC-PAD)