Trial-Ready Cohort for the Prevention of Alzheimer's Dementia (TRC-PAD)
Recruiting
The Trial-Ready Cohort for the Prevention of Alzheimer's Dementia (TRC-PAD) is an observational study designed to create a group of cognitively healthy volunteers willing to participate in clinical trials aimed at discovering treatments that will reduce the risk of developing Alzheimer's dementia. TRC-PAD will help researchers enroll participants into these trials quickly. To join the TRC-PAD study, individuals must first complete an Alzheimer Prevention Trials (APT) Webstudy online questionnaire and memory tests. If selected, participants will make an in-person visit to a study site, where they will complete several assessments to see if they qualify to join the cohort. These assessments include a positron emission tomography (PET) brain scan, cerebrospinal fluid collection, tests of memory and thinking, questionnaires about daily functioning, mood and behavior, genetic testing, and routine blood and urine tests. Individuals who enroll in TRC-PAD will come back to the clinic every six months for brief follow-up visits, with questionnaires and testing, until they qualify for a clinical trial.
Minimum Age | Maximum Age | Gender | Healthy Volunteers |
---|---|---|---|
50 Years | 85 Years | All | Yes |
- Global Clinical Dementia Rating score of 0 or 0.5 and no diagnosis of dementia
- Study partner who is willing to participate as a source of information and has at least weekly contact (in-person, via telephone, or electronic communication) with the participant
- Good general health
- Adequate visual and auditory ability to allow neuropsychological testing
- Fluent in English or Spanish
- Females who are not surgically sterile or postmenopausal for 2 years must receive a negative pregnancy test prior to amyloid PET scan
- Completed six grades of education or has a good work history
- Evidence of elevated or intermediate levels of brain amyloid, as assessed by amyloid PET or cerebrospinal fluid data; prior amyloid testing results may be used with approval from the Coordinating Center
- Treatment with another anti-amyloid investigational drug or other intervention within past 12 months
- Enrolled in another interventional clinical trial within the last 12 weeks
- Any significant neurological disease such as Alzheimer's disease dementia, Parkinson's disease, multi-infarct dementia, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma
- Major depression, bipolar disorder, agitation or behavioral problems within the past 3 months that could lead to difficulty complying with the study; history of schizophrenia
- History of alcohol or substance abuse or dependence within the past 2 years
- Clinically significant or unstable medical condition, including uncontrolled hypertension, uncontrolled diabetes, or significant cardiac, pulmonary, renal, hepatic, endocrine, or other systemic disease
- History within the last 3 years of a primary or recurrent malignant disease, with the exception of non-melanoma skin cancers, resected cutaneous squamous cell carcinoma in situ, basal cell carcinoma, cervical carcinoma in situ, or in situ prostate cancer with normal prostate-specific antigen post-treatment
- Clinically significant abnormalities in vitamin B12 or thyroid function tests
- Clinically significant abnormalities in laboratory tests or electrocardiogram
- For participants undergoing cerebrospinal fluid collection, current blood clotting or bleeding disorder
Name | City | State | Zip | Status | Primary Contact |
---|---|---|---|---|---|
University of Alabama |
Birmingham | Alabama | 35294 | Recruiting |
Amber Watkins 205-996-3679 amberwatkins@uabmc.edu |
Banner Alzheimer's Institute |
Phoenix | Arizona | 85006 | Recruiting |
Daniela Tauchmann 602-839-4891 Daniela.Tauchmann@bannerhealth.com |
Banner Sun Health Research Institute |
Sun City | Arizona | 85351 | Recruiting |
Nadira Trncic 623-832-6590 Nadira.Trncic@bannerhealth.com |
University of California, Irvine |
Irvine | California | 92697 | Recruiting |
Beatriz Vides 949-824-3250 byanez@uci.edu |
University of Southern California |
Los Angeles | California | 90033 | Recruiting |
Mauricio Becerra 329-442-7594 Mauricio.Becerra@usc.edu |
Hoag Pickup Family Neurosciences Institute |
Newport Beach | California | 92663 | Not yet recruiting |
|
University of California, San Francisco |
San Francisco | California | 94143 | Not yet recruiting |
|
University of California, Davis |
Walnut Creek | California | 945985900 | Not yet recruiting |
|
Yale University |
New Haven | Connecticut | 06510 | Recruiting |
Carol Gunnoud 203-764-8107 carol.gunnoud@yale.edu |
Georgetown University |
Washington | District of Columbia | 200072145 | Recruiting |
Kelly McCann 202-687-0413 keb53@georgetown.edu |
Mayo Clinic Jacksonville |
Jacksonville | Florida | 32224 | Not yet recruiting |
|
Wien Center for Alzheimer's Disease |
Miami Beach | Florida | 33140 | Recruiting |
Rosemarie A Rodriguez 305-674-2121 Rosemarie.Rodriguez@msmc.com |
Synexus Clinical Research Orlando |
Orlando | Florida | 32806 | Not yet recruiting |
|
Brain Matters Research |
Stuart | Florida | 34997 | Recruiting |
Jetliza Lesmes 561-381-9060 jlesmes@ergclinical.com |
University of South Florida - Health Byrd Alzheimer Institute |
Tampa | Florida | 336134808 | Recruiting |
Juris Janavs 813-396-0637 jjanavs@usf.edu |
Synexus Clinical Research, The Villages |
The Villages | Florida | 32162-7116 | Not yet recruiting |
|
Emory University |
Atlanta | Georgia | 30329 | Recruiting |
Phyllis L Vaughn 404-712-6901 pvaughn@emory.edu |
Columbus Memory Center |
Columbus | Georgia | 31909 | Not yet recruiting |
|
Northwestern University |
Chicago | Illinois | 60611 | Not yet recruiting |
|
Rush University |
Chicago | Illinois | 60612 | Recruiting |
Peter Liambotis 312-563-0523 Peter_J_Liambotis@rush.edu |
Indiana University |
Indianapolis | Indiana | 46202 | Recruiting |
Kala Hall 317-963-1867 kalhall@iupui.edu |
University of Kansas |
Fairway | Kansas | 66205 | Recruiting |
Debra Brook 901-866-9252 dbrook@kumc.edu |
University of Kentucky |
Lexington | Kentucky | 405042681 | Recruiting |
Hope Esposito 859-323-4547 hope.esposito@uky.edu |
Johns Hopkins University |
Baltimore | Maryland | 212242764 | Recruiting |
Samantha Horn 410-550-9020 shorn8@jhmi.edu |
Brigham & Women's Hospital |
Boston | Massachusetts | 21155804 | Recruiting |
Samantha Kuney 617-732-7992 skuney@bwh.harvard.edu |
Donald S. Marks, MD., P.C. |
Plymouth | Massachusetts | 02360 | Not yet recruiting |
|
University of Michigan |
Ann Arbor | Michigan | 48105 | Recruiting |
Lauren Mackenzie 734-232-2415 spearsl@umich.edu |
Mayo Clinic Rochester |
Rochester | Minnesota | 55905 | Recruiting |
Kimberly Etbauer 507-284-1324 etbauer.kimberly@mayo.edu |
Washington University, St. Louis |
Saint Louis | Missouri | 631082215 | Recruiting |
Marta Santos 314-286-2363 mhsantos@wustl.edu |
Cleveland Clinic Lou Ruvo Center for Brain Health |
Las Vegas | Nevada | 891060100 | Recruiting |
Grey Rivera riverag@ccf.org |
University of Rochester Medical Center |
Rochester | New York | 14620 | Recruiting |
Esmeralda Morales 585-760-6562 esmeraldamorales@urmc.rochester.edu |
Wake Forest University Health Sciences |
Winston-Salem | North Carolina | 27157 | Recruiting |
Abigail O'Connell 336-716-7976 abigail.oconnell@wakehealth.edu |
Case Western Reserve University |
Beachwood | Ohio | 441224312 | Recruiting |
Megan Posan Megan.Posan2@UHhospitals.org |
Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland |
Cleveland | Ohio | 44195 | Recruiting |
Grey Rivera 702-701-7967 riverag@ccf.org |
Ohio State University |
Columbus | Ohio | 43210 | Not yet recruiting |
|
Summit Research Network, Oregon |
Portland | Oregon | 97210 | Not yet recruiting |
|
Oregon Health & Science University |
Portland | Oregon | 972393011 | Recruiting |
Natasha Spoden 503-494-0976 spoden@ohsu.edu |
Abington Neurological Associates |
Abington | Pennsylvania | 19001 | Not yet recruiting |
|
University of Pennsylvania |
Philadelphia | Pennsylvania | 19104 | Recruiting |
Allison Weiss 215-615-3133 allison.weiss@uphs.upenn.edu |
Rhode Island Hospital |
Providence | Rhode Island | 02903 | Recruiting |
Quinneil Simmons 401-444-2421 quinneil.simmons@lifespan.org |
Butler Hospital Memory and Aging Program |
Providence | Rhode Island | 02906 | Recruiting |
Katherine Daneault 860-908-6738 KDaneault@buttler.org |
Roper St. Francis Hospital |
Charleston | South Carolina | 29401 | Recruiting |
Allison Lapp 843-724-2214 allison.lapp@rsfh.com |
University of Texas Southwestern Medical Center |
Dallas | Texas | 75390 | Recruiting |
Amy Browning 214-645-1972 Amy.browning@utsouthwestern.edu |
University of North Texas Health Sciences Center |
Fort Worth | Texas | 76107 | Recruiting |
Wilma Burns 817-735-2948 Wilma.Burns@unthsc.edu |
University of Washington / Seattle Institute for Biomedical and Clinical Research |
Seattle | Washington | 98108 | Recruiting |
Anita Ranta 206-764-2339 rantaa@uw.edu |
University of Southern California
- National Institute on Aging (NIA)
- Alzheimer's Therapeutic Research Institute
- Alzheimer's Clinical Trials Consortium
- Brigham and Women's Hospital
- Cleveland Clinic Lou Ruvo Center for Brain Health
Name | Role | Affiliation |
---|---|---|
Paul Aisen, MD | Principal Investigator | USC Alzheimer's Therapeutic Research Institute (ATRI) |
Reisa Sperling, MD | Principal Investigator | Brigham and Women's Hospital |
Jeffrey Cummings, MD | Principal Investigator | Cleveland Clinic Lou Ruvo Center for Brain Health |
Name | Phone | |
---|---|---|
APT / TRC Recruitment Team | 858-877-3135 | info@aptwebstudy.org |
Trial Ready Cohort for the Prevention of Alzheimer's Dementia (TRC-PAD)
- Amariglio RE, Donohue MC, Marshall GA, Rentz DM, Salmon DP, Ferris SH, Karantzoulis S, Aisen PS, Sperling RA; Alzheimers Disease Cooperative Study. Tracking early decline in cognitive function in older individuals at risk for Alzheimer disease dementia: the Alzheimer's Disease Cooperative Study Cognitive Function Instrument. JAMA Neurol. 2015 Apr;72(4):446-54. doi: 10.1001/jamaneurol.2014.3375. Erratum in: JAMA Neurol. 2015 May;72(5):608.
- Mormino EC, Papp KV, Rentz DM, Donohue MC, Amariglio R, Quiroz YT, Chhatwal J, Marshall GA, Donovan N, Jackson J, Gatchel JR, Hanseeuw BJ, Schultz AP, Aisen PS, Johnson KA, Sperling RA. Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated amyloid . Alzheimers Dement. 2017 Sep;13(9):1004-1012. doi: 10.1016/j.jalz.2017.01.018. Epub 2017 Feb 28.