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Trial-Ready Cohort for the Prevention of Alzheimer's Dementia (TRC-PAD)


The Trial-Ready Cohort for the Prevention of Alzheimer's Dementia (TRC-PAD) is an observational study designed to create a group of cognitively healthy volunteers willing to participate in clinical trials aimed at discovering treatments that will reduce the risk of developing Alzheimer's dementia. TRC-PAD will help researchers enroll participants into these trials quickly. To join the TRC-PAD study, individuals must first complete an Alzheimer Prevention Trials (APT) Webstudy online questionnaire and memory tests. If selected, participants will make an in-person visit to a study site, where they will complete several assessments to see if they qualify to join the cohort. These assessments include a positron emission tomography (PET) brain scan, cerebrospinal fluid collection, tests of memory and thinking, questionnaires about daily functioning, mood and behavior, genetic testing, and routine blood and urine tests. Individuals who enroll in TRC-PAD will come back to the clinic every six months for brief follow-up visits, with questionnaires and testing, until they qualify for a clinical trial.

Minimum Age Maximum Age Gender Healthy Volunteers
50 Years 85 Years All Yes
June 4, 2019
April 30, 2023

  • Global Clinical Dementia Rating score of 0 or 0.5 and no diagnosis of dementia
  • Study partner who is willing to participate as a source of information and has at least weekly contact (in-person, via telephone, or electronic communication) with the participant
  • Good general health
  • Adequate visual and auditory ability to allow neuropsychological testing
  • Fluent in English or Spanish
  • Females who are not surgically sterile or postmenopausal for 2 years must receive a negative pregnancy test prior to amyloid PET scan
  • Completed six grades of education or has a good work history
  • Evidence of elevated or intermediate levels of brain amyloid, as assessed by amyloid PET or cerebrospinal fluid data; prior amyloid testing results may be used with approval from the Coordinating Center

  • Treatment with another anti-amyloid investigational drug or other intervention within past 12 months
  • Enrolled in another interventional clinical trial within the last 12 weeks
  • Any significant neurological disease such as Alzheimer's disease dementia, Parkinson's disease, multi-infarct dementia, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, or history of significant head trauma
  • Major depression, bipolar disorder, agitation or behavioral problems within the past 3 months that could lead to difficulty complying with the study; history of schizophrenia
  • History of alcohol or substance abuse or dependence within the past 2 years
  • Clinically significant or unstable medical condition, including uncontrolled hypertension, uncontrolled diabetes, or significant cardiac, pulmonary, renal, hepatic, endocrine, or other systemic disease
  • History within the last 3 years of a primary or recurrent malignant disease, with the exception of non-melanoma skin cancers, resected cutaneous squamous cell carcinoma in situ, basal cell carcinoma, cervical carcinoma in situ, or in situ prostate cancer with normal prostate-specific antigen post-treatment
  • Clinically significant abnormalities in vitamin B12 or thyroid function tests
  • Clinically significant abnormalities in laboratory tests or electrocardiogram
  • For participants undergoing cerebrospinal fluid collection, current blood clotting or bleeding disorder

Name City State Zip Status Primary Contact
University of Alabama
Birmingham Alabama 35294 Recruiting Amber Watkins
Banner Alzheimer's Institute
Phoenix Arizona 85006 Recruiting Daniela Tauchmann
Banner Sun Health Research Institute
Sun City Arizona 85351 Recruiting Nadira Trncic
University of California, Irvine
Irvine California 92697 Recruiting Beatriz Vides
University of Southern California
Los Angeles California 90033 Recruiting Mauricio Becerra
Hoag Pickup Family Neurosciences Institute
Newport Beach California 92663 Not yet recruiting

University of California, San Francisco
San Francisco California 94143 Not yet recruiting

University of California, Davis
Walnut Creek California 945985900 Not yet recruiting

Yale University
New Haven Connecticut 06510 Recruiting Carol Gunnoud
Georgetown University
Washington District of Columbia 200072145 Recruiting Kelly McCann
Mayo Clinic Jacksonville
Jacksonville Florida 32224 Not yet recruiting

Wien Center for Alzheimer's Disease
Miami Beach Florida 33140 Recruiting Rosemarie A Rodriguez
Synexus Clinical Research Orlando
Orlando Florida 32806 Not yet recruiting

Brain Matters Research
Stuart Florida 34997 Recruiting Jetliza Lesmes
University of South Florida - Health Byrd Alzheimer Institute
Tampa Florida 336134808 Recruiting Juris Janavs
Synexus Clinical Research, The Villages
The Villages Florida 32162-7116 Not yet recruiting

Emory University
Atlanta Georgia 30329 Recruiting Phyllis L Vaughn
Columbus Memory Center
Columbus Georgia 31909 Not yet recruiting

Northwestern University
Chicago Illinois 60611 Not yet recruiting

Rush University
Chicago Illinois 60612 Recruiting Peter Liambotis
Indiana University
Indianapolis Indiana 46202 Recruiting Kala Hall
University of Kansas
Fairway Kansas 66205 Recruiting Debra Brook
University of Kentucky
Lexington Kentucky 405042681 Recruiting Hope Esposito
Johns Hopkins University
Baltimore Maryland 212242764 Recruiting Samantha Horn
Brigham & Women's Hospital
Boston Massachusetts 21155804 Recruiting Samantha Kuney
Donald S. Marks, MD., P.C.
Plymouth Massachusetts 02360 Not yet recruiting

University of Michigan
Ann Arbor Michigan 48105 Recruiting Lauren Mackenzie
Mayo Clinic Rochester
Rochester Minnesota 55905 Recruiting Kimberly Etbauer
Washington University, St. Louis
Saint Louis Missouri 631082215 Recruiting Marta Santos
Cleveland Clinic Lou Ruvo Center for Brain Health
Las Vegas Nevada 891060100 Recruiting Grey Rivera
University of Rochester Medical Center
Rochester New York 14620 Recruiting Esmeralda Morales
Wake Forest University Health Sciences
Winston-Salem North Carolina 27157 Recruiting Abigail O'Connell
Case Western Reserve University
Beachwood Ohio 441224312 Recruiting Megan Posan
Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland
Cleveland Ohio 44195 Recruiting Grey Rivera
Ohio State University
Columbus Ohio 43210 Not yet recruiting

Summit Research Network, Oregon
Portland Oregon 97210 Not yet recruiting

Oregon Health & Science University
Portland Oregon 972393011 Recruiting Natasha Spoden
Abington Neurological Associates
Abington Pennsylvania 19001 Not yet recruiting

University of Pennsylvania
Philadelphia Pennsylvania 19104 Recruiting Allison Weiss
Rhode Island Hospital
Providence Rhode Island 02903 Recruiting Quinneil Simmons
Butler Hospital Memory and Aging Program
Providence Rhode Island 02906 Recruiting Katherine Daneault
Roper St. Francis Hospital
Charleston South Carolina 29401 Recruiting Allison Lapp
University of Texas Southwestern Medical Center
Dallas Texas 75390 Recruiting Amy Browning
University of North Texas Health Sciences Center
Fort Worth Texas 76107 Recruiting Wilma Burns
University of Washington / Seattle Institute for Biomedical and Clinical Research
Seattle Washington 98108 Recruiting Anita Ranta

University of Southern California

  • National Institute on Aging (NIA)
  • Alzheimer's Therapeutic Research Institute
  • Alzheimer's Clinical Trials Consortium
  • Brigham and Women's Hospital
  • Cleveland Clinic Lou Ruvo Center for Brain Health

Name Role Affiliation
Paul Aisen, MD Principal Investigator USC Alzheimer's Therapeutic Research Institute (ATRI)
Reisa Sperling, MD Principal Investigator Brigham and Women's Hospital
Jeffrey Cummings, MD Principal Investigator Cleveland Clinic Lou Ruvo Center for Brain Health

Name Phone Email
APT / TRC Recruitment Team 858-877-3135


Trial Ready Cohort for the Prevention of Alzheimer's Dementia (TRC-PAD)