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Transcranial Magnetic Stimulation for Mild and Moderate Alzheimer's Disease


This study will test the effects of repetitive transcranial magnetic stimulation (rTMS), a noninvasive brain stimulation therapy, on cognitively healthy older adults and in people with amnestic mild cognitive impairment due to Alzheimer's disease. The intervention is designed to improve cognition, including memory, in older adults.

Minimum Age Maximum Age Gender Healthy Volunteers
60 Years 85 Years All Yes
March 2, 2020
March 1, 2024

  • Fluent English speaker
  • Willing and able to consent to the study directions and undergo imaging and neuropsychological testing at the specified time points
  • Patients with very mild or mild cognitive impairment (CDR 0.5 or CDR 1)
  • Participants with amnestic mild cognitive impairment must be able to bring a study partner to all visits

  • History of head trauma involving a loss of consciousness or alteration in consciousness
  • Physician diagnosis of another major neurologic or psychiatric condition
  • Known presence of a structural brain lesion (e.g., tumor, cortical infarct)
  • Any condition that makes imaging by MRI unsafe, such as the presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body
  • Longstanding history (i.e., longer than 10 years) of alcohol or substance abuse
  • Any significant illness or unstable medical condition that could make it difficult to comply with the study directions
  • Unable or unwilling to return for follow-up, undergo neuropsychological testing, transcranial magnetic stimulation, and MRI imaging

This study will use repetitive TMS to stimulate nodes of the default mode network in the brain, which is thought to support memory and be affected by Alzheimer's disease. Following the stimulation intervention, participants will receive a functional connectivity MRI to determine any changes in the brain. Participants will also undergo neuropsychological and memory testing to determine improvements in cognition. All study participants will receive the TMS intervention.

Name City State Zip Status Primary Contact
Massachuetts General Hospital
Charlestown Massachusetts 02129 Recruiting Courtney Sullivan

Massachusetts General Hospital

Name Phone Email
Jessica A Collins, PhD 617-726-6217


TMS in Preclinical and Prodromal AD: Modulation of Brain Networks and Memory